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New gene testing method can identify mutations, prioritize variants in breast and ovarian cancer genes

A research team led by an award-winning genomicist at Western University has developed a new method for identifying mutations and prioritizing variants in breast and ovarian cancer genes, which will not only reduce the number of possible variants for doctors to investigate, but also increase the number of patients that are properly diagnosed.

29 Apr 2016

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets, according to a collaboration between the Perelman School of Medicine at the University of Pennsylvania, the University of Arizona Health Sciences, and Vanderbilt University. The group published their findings this month in npj Genomic Medicine.

29 Apr 2016

Gut bacteria linked to risk of bloodstream infections after chemotherapy

A new study led by researchers at the University of Minnesota and Nantes University Hospital in France shows that the bacteria in people's gut may predict their risk of life-threatening blood infections following high-dose chemotherapy.

29 Apr 2016

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding genes - less than 2 percent of the total - but 70 percent of the genome is made into non-gene-encoding RNA.

29 Apr 2016

New study on retroviral DNA could help improve treatments for HIV infection

When retroviruses such as HIV infect a cell, they first make a copy of their RNA genome in the form of DNA. The relatively short viral DNA strand then moves to the cell nucleus, where it inserts itself into the host cell's DNA.

27 Apr 2016

Modernization of screening methods in sperm banks could protect future children from highly heritable diseases

U.S. sperm banks perform genetic testing to screen for and disqualify carriers of a limited number of recessive disease mutations, but more comprehensive and affordable DNA-based screening methods are now available that can detect many more disease-causing genetic variations.

27 Apr 2016

TGen scientists trace likely origins, dispersal of fungus that causes Valley Fever

Using the latest in genomic analysis technologies, scientists at the Translational Genomics Research Institute have tracked the likely origins and dispersal of the fungus that causes Valley Fever, according to a study published today in the journal mBio, the premiere journal for reporting high impact microbiological research.

27 Apr 2016

University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

A team of researchers led by the University of Leicester has shed new light on how the regulation machinery that controls gene expression works by characterising a complex known as the NuRD complex.

27 Apr 2016

Takara Bio USA, Integrated DNA Technologies collaborate to enhance transcriptome research

Takara Bio USA, Inc. (TBUSA, formerly Clontech Laboratories, Inc.), a wholly owned subsidiary of Takara Bio Inc., and Integrated DNA Technologies (IDT) today announced a new collaboration to support targeted RNA sequencing.

From Integrated DNA Technologies 27 Apr 2016

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

Fragile X syndrome (FXS) is the most common genetically inherited cause of intellectual disability in humans. New research shows how the hormone insulin -- usually associated with diabetes -- is involved in the daily activity patterns and cognitive deficits in the fruitfly model of FXS, according to a new study from the Perelman School of Medicine at the University of Pennsylvania published online this month in Molecular Psychiatry in advance of the print issue.

27 Apr 2016

Low levels of vitamin D, methylation in black teens may increase cancer risk

Low levels of vitamin D in black teens correlates with low activity of a major mechanism for controlling gene expression that may increase their risk of cancer and other disease, researchers report.

26 Apr 2016

Researchers develop real-time single molecule electronic DNA sequencing platform

Researchers from Columbia University, with colleagues at Genia Technologies, Harvard University and the National Institute of Standards and Technology report achieving real-time single molecule electronic DNA sequencing at single-base resolution using a protein nanopore array.

25 Apr 2016

NASA's research program uses omics to look more closely at individual health

NASA's Human Research Program is releasing the first half of a video series entitled Omics: Exploring Space Through You to highlight its Twins Study, in conjunction with its National DNA Day Reddit Ask Me Anything event at 10 a.m. CDT/11 a.m. EDT, Monday, April 25, 2016. The series explores space through you by using omics to look more closely at individual health.

22 Apr 2016

Wellderly study finds link between cognitive decline genes and healthy aging

An eight-year-long accrual and analysis of the whole genome sequences of healthy elderly people, or "Wellderly," has revealed a higher-than-normal presence of genetic variants offering protection from cognitive decline, researchers from the Scripps Translational Science Institute (STSI) reported today in the journal Cell.

22 Apr 2016

CUMC researchers identify new neurodevelopmental syndrome

A multicenter research team led by Columbia University Medical Center has discovered a new neurodevelopmental syndrome and the genetic mutations that cause it. The discovery is an important step toward creating targeted therapies for individuals with this syndrome, which causes severe developmental delays, abnormal muscle tone, seizures, and eye complications.

22 Apr 2016

Scientists identify genetic mechanisms behind development of myopia

Myopia, also known as short-sightedness or near-sightedness, is the most common disorder affecting the eyesight and it is on the increase. The causes are both genetic and environmental.

22 Apr 2016

Researchers use highly accurate biomarker to measure aging in HIV infected patients

Thanks to combination antiretroviral therapies, many people with HIV can expect to live decades after being infected. Yet doctors have observed these patients often show signs of premature aging.

22 Apr 2016

Subtle changes in protein-coding gene may cause different genetic disorders

It has been disorienting to the scientific and medical community as to why different subtle changes in a protein-coding gene causes many different genetic disorders in different patients -- including premature aging, nerve problems, heart problems and muscle problems. no other gene works like this. According to a new study, co-authored by Binghamton University faculty Eric Hoffman, it has to do with cell "commitment."

22 Apr 2016

Scientists develop CRISPRainbow to study genome structure in real time

CRISPRainbow, a new technology using CRISPR/Cas9 developed by scientists at UMass Medical School, allows researchers to tag and track up to seven different genomic locations in live cells. This labeling system, details of which were published in Nature Biotechnology, will be an invaluable tool for studying the structure of the genome in real time.

21 Apr 2016

Scientists identify transposable element in certain bird genomes

In rare instances, DNA is known to have jumped from one species to another. If a parasite's DNA jumps to its host's genome, it could leave evidence of that parasitic interaction that could be found millions of years later -- a DNA 'fossil' of sorts.

21 Apr 2016

Genome News and Research

New gene testing method can identify mutations, prioritize variants in breast and ovarian cancer genes

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

Gut bacteria linked to risk of bloodstream infections after chemotherapy

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

New study on retroviral DNA could help improve treatments for HIV infection

Modernization of screening methods in sperm banks could protect future children from highly heritable diseases

TGen scientists trace likely origins, dispersal of fungus that causes Valley Fever

University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

Takara Bio USA, Integrated DNA Technologies collaborate to enhance transcriptome research

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

Low levels of vitamin D, methylation in black teens may increase cancer risk

Researchers develop real-time single molecule electronic DNA sequencing platform

NASA's research program uses omics to look more closely at individual health

Wellderly study finds link between cognitive decline genes and healthy aging

CUMC researchers identify new neurodevelopmental syndrome

Scientists identify genetic mechanisms behind development of myopia

Researchers use highly accurate biomarker to measure aging in HIV infected patients

Subtle changes in protein-coding gene may cause different genetic disorders

Scientists develop CRISPRainbow to study genome structure in real time

Scientists identify transposable element in certain bird genomes

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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