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Whole genome sequencing reveals severe intellectual disability in patients

With a new technique, which at once studies the whole genome, a genetic cause can be identified in six out of ten children with severe intellectual disability. This makes the method more successful than all the usual methods together.

5 Jun 2014

Thermo Fisher, Cellectis sign agreements on TALEN gene editing technology

Cellectis, a leader of engineered CART cell therapies, and Thermo Fisher Scientific announced today that they have entered into a series of agreements covering the uses of TAL nucleases under the brand name TALEN™.

5 Jun 2014

Scientists reproduce chromosomal modifications in human cells that cause certain cancer

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Centro Nacional de Investigaciones Oncol-gicas (CNIO) have succeeded in reproducing, in human cells, the chromosomal translocations that cause two types of cancer: acute myeloid leukemia and Ewing's sarcoma.

5 Jun 2014

Four new genes cause inherited breast cancer risk

Four new genes have been added to the growing list of those known to cause increased breast cancer risk when mutated through the efforts of researchers at Huntsman Cancer Institute (HCI) at the University of Utah, who lead an international consortium working to find more gene mutations that cause inherited breast cancer susceptibilities.

5 Jun 2014

My Cancer Genome unveils second-generation mobile app

My Cancer Genome (MCG), an online precision cancer medicine tool developed by researchers at Vanderbilt-Ingram Cancer Center, has unveiled a free, second-generation mobile app that provides even more information about genetic alterations in various types of cancer and the therapies available to treat those alterations.

5 Jun 2014

Researchers reproduce tumor chromosomal translocations in human cells

Scientists from the Spanish National Cancer Research Centre and the Spanish National Cardiovascular Research Centre have been able to reproduce, for the first time in human cells, chromosomal translocations associated with two types of cancer: acute myeloid leukaemia and Ewing's sarcoma.

4 Jun 2014

Scientists design search engine to identify functionally linked genes

Our bodies are as vast as oceans and space, composed of a dizzying number of different types of cells. Exploration reaches far, yet the genes that make each cell and tissue unique have remained largely obscure.

4 Jun 2014

Variations in BRCA2 and CHEK2 genes can increase lung cancer risk, study finds

New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations.

3 Jun 2014

Ovarian cancer patients with molecular subtypes benefit from bevacizumab

Molecular sequencing could identify ovarian cancer patients who are most likely to benefit from treatment with bevacizumab (Avastin), a Mayo Clinic-led study has found.

2 Jun 2014

Scientists define genetic cause for two types of birth defects in newborn boys

Baylor College of Medicine scientists defined a previously unrecognized genetic cause for two types of birth defects found in newborn boys, described in a report published today in the journal Nature Medicine.

2 Jun 2014

New genes involved in taste perception effective in weight loss and improve quality of life

New understanding of the genes involved in taste perception and food preferences could lead to personalised nutrition plans effective not just in weight loss but in avoiding diseases such as cancer, depression, and hypertension, Italian researchers will tell the annual conference of the European Society of Human Genetics (ESHG) today (Monday).

2 Jun 2014

Particular genetic variation in humans linked with blond hair

A single-letter change in the genetic code is enough to generate blond hair in humans, in dramatic contrast to our dark-haired ancestors.

2 Jun 2014

New cancer panel holds promise in detection of previously undetected viral, cancer mutations

Researchers from Sanford Health and Chronix Biomedical today announced that results from a pilot study demonstrating the utility of a new cancer panel to detect previously undetected viral and cancer mutations are to be reported in a poster presentation titled "Detection of novel HPV mutations and chromosomal number imbalance (CNI) in oropharyngeal and laryngeal cancer using next-generation sequencing (NGS)" (Abstract #6072) at the American Society of Clinical Oncology Annual Meeting (ASCO 2014) being held from May 30 through June 3, 2014 in Chicago.

31 May 2014

New data highlights molecular profiling in guiding treatment of patients with gynecologic malignancies

Caris Life Sciences®, a leading biosciences company focused on fulfilling the promise of precision medicine, announced today the presentation of clinical data from studies demonstrating the potential utility of comprehensive molecular profiling in guiding treatment of patients with gynecologic malignancies, including breast cancers and ovarian cancer.

31 May 2014

CIRM grants $5.6 million to develop HIV/AIDS therapeutic using Sangamo's ZFN genome-editing technology

Sangamo BioSciences, Inc. announced that the California Institute for Regenerative Medicine (CIRM) has granted a $5.6 million Strategic Partnership Award to fund clinical studies at City of Hope to develop a potentially curative ZFP Therapeutic for HIV/AIDS based on the application of Sangamo's zinc finger nuclease (ZFN) genome-editing technology in hematopoietic stem/progenitor cells (HSPCs).

31 May 2014

Appistry announces agreement with PGDx to include CancerSelect panel in Appistry CloudDx

Appistry, Inc., a leading provider of tools, software, and services that bring the power of genomics to next-generation medicine, today announced an agreement with Personal Genome Diagnostics (PGDx) to include the company's CancerSelect™ panel in Appistry's recently released Appistry CloudDx™ genomics testing service.

31 May 2014

Researchers uncover previously unidentified genes responsible for keloid scarring

Researchers at Henry Ford Hospital in Detroit have uncovered previously unidentified genes that may be responsible for keloid scarring, a discovery that could unlock the mystery of keloid development and provide insight for more effective treatment.

30 May 2014

Blood gene expression profile identifies patients with elevated risk of cardiovascular death

A study of 338 patients with coronary artery disease has identified a gene expression profile associated with an elevated risk of cardiovascular death. Used with other indicators such as biochemical markers and family history, the profile - based on a simple blood test - may help identify patients who could benefit from personalized treatment and counseling designed to address risk factors.

30 May 2014

Findings have important implications for improving war wound healing

War wounds that heal successfully frequently contain different microbial species from those that heal poorly, according to a paper published ahead of print in the Journal of Clinical Microbiology.

30 May 2014

New insights into egg selection may have broad implications for women's health, fertility

A woman's supply of eggs is a precious commodity because only a few hundred mature eggs can be produced throughout her lifetime and each must be as free as possible from genetic damage.

30 May 2014

Genome News and Research

Whole genome sequencing reveals severe intellectual disability in patients

Thermo Fisher, Cellectis sign agreements on TALEN gene editing technology

Scientists reproduce chromosomal modifications in human cells that cause certain cancer

Four new genes cause inherited breast cancer risk

My Cancer Genome unveils second-generation mobile app

Researchers reproduce tumor chromosomal translocations in human cells

Scientists design search engine to identify functionally linked genes

Variations in BRCA2 and CHEK2 genes can increase lung cancer risk, study finds

Ovarian cancer patients with molecular subtypes benefit from bevacizumab

Scientists define genetic cause for two types of birth defects in newborn boys

New genes involved in taste perception effective in weight loss and improve quality of life

Particular genetic variation in humans linked with blond hair

New cancer panel holds promise in detection of previously undetected viral, cancer mutations

New data highlights molecular profiling in guiding treatment of patients with gynecologic malignancies

CIRM grants $5.6 million to develop HIV/AIDS therapeutic using Sangamo's ZFN genome-editing technology

Appistry announces agreement with PGDx to include CancerSelect panel in Appistry CloudDx

Researchers uncover previously unidentified genes responsible for keloid scarring

Blood gene expression profile identifies patients with elevated risk of cardiovascular death

Findings have important implications for improving war wound healing

New insights into egg selection may have broad implications for women's health, fertility

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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