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ATF3 gene may be the crucial link between stress and breast cancer: Study

In an unexpected finding, scientists have linked the activation of a stress gene in immune-system cells to the spread of breast cancer to other parts of the body.

23 Aug 2013

Scientists reveal why TB is a successful pathogen

By any measure, tuberculosis is a wildly successful pathogen. It infects as many as two billion people in every corner of the world, with a new infection of a human host estimated to occur every second.

22 Aug 2013

Medical investigators discover new aspect of gene-splicing process that produces mRNA

A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his team from the Perelman School of Medicine at the University of Pennsylvania, discovered an entirely new aspect of the gene-splicing process that produces messenger RNA (mRNA).

22 Aug 2013

Oxford Gene Technology releases next generation sequencing survey results

Oxford Gene Technology, provider of innovative genetics research and biomarker solutions to advance molecular medicine, has released the results from a recent survey of researchers using next generation sequencing.

From Oxford Gene Technology 21 Aug 2013

Researchers identify genome-wide locus for serious gastrointestinal condition in infants

Researchers have identified a new genome-wide significant locus (the place a gene occupies on a chromosome) for infantile hypertrophic pyloric stenosis (IHPS), a serious gastrointestinal condition associated with gastrointestinal obstruction, according to a study in the August 21 issue of JAMA. Characteristics of this locus also suggest the possibility of an inverse relationship between levels of circulating cholesterol in neonates and IHPS risk.

21 Aug 2013

Research suggests gene therapy approach may be feasible option to treat Rett Syndrome

The concept behind gene therapy is simple: deliver a healthy gene to compensate for one that is mutated. New research published today in the Journal of Neuroscience suggests this approach may eventually be a feasible option to treat Rett Syndrome, the most disabling of the autism spectrum disorders.

21 Aug 2013

Researchers create mouse models to advance the study of unusual deadly diseases

By directly manipulating a portion of the prion protein-coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans. The highly accurate reproduction of disease pathology seen with these models should advance the study of these unusual but deadly diseases.

20 Aug 2013

Illumina announces availability of its newest reagent kits for MiSeq benchtop sequencer

Illumina, Inc. today announced the availability of its newest reagent kits for the MiSeq, the industry's most accurate and easiest-to-use benchtop sequencer. The improved chemistry doubles sequencing output to 15 gigabases (Gb) by increasing the number of sequencing reads (up to 25 million reads) and overall read length (up to 2x300 base pairs). These innovations enable researchers to perform new applications including exome sequencing on the MiSeq.

From Illumina, Inc. 19 Aug 2013

ATSP-7041 stapled peptide activates p53, suppresses tumor growth in animal models

Aileron Therapeutics, Inc., a clinical stage biopharmaceutical company that is developing first-in-class therapeutics based on its proprietary Stapled Peptide drug platform, announced today the publication of preclinical data on ATSP-7041, a potent and selective stapled peptide re-activator of the wild type p53 tumor suppressor protein.

17 Aug 2013

Study provides information that validates genetic basis of adaptation to high altitudes

Research led by scientists from the University of California, San Diego has decoded the genetic basis of chronic mountain sickness (CMS) or Monge's disease. Their study provides important information that validates the genetic basis of adaptation to high altitudes, and provides potential targets for CMS treatment.

16 Aug 2013

Mutational signatures in DNA explain genetic development, history of cancers in patients

Researchers have provided the first comprehensive compendium of mutational processes that drive tumour development. Together, these mutational processes explain most mutations found in 30 of the most common cancer types. This new understanding of cancer development could help to treat and prevent a wide-range of cancers.

16 Aug 2013

Researchers find possible mechanism of how cellular memory works

The DNA in human cells is translated into a multitude of proteins required for a cell to function. When, where and how proteins are expressed is determined by regulatory DNA sequences and a group of proteins, known as transcription factors, that bind to these DNA sequences.

16 Aug 2013

Scientists have made breakthrough in understanding cancer-promoting action of herbal products

A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid (AA), a natural product of Aristolochia plants traditionally used in some Asian herbal remedies for weight loss and slimming.

14 Aug 2013

Study shows enhancer RNA molecules may open new avenues for gene therapy

A study investigating the function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy. According to the study researchers, altering the production and function of these molecules could affect the expression of genes and, in consequence, possibly also the progression of various diseases.

14 Aug 2013

Researchers identify clear genetic risk factors in patients with severe epilepsy

Neurologists and epilepsy researchers from NYU Langone Medical Center were among scientists who have 329 random genetic mutations associated with two of the most severe forms of epilepsy, according to a paper published today in Nature.

13 Aug 2013

Viewpoints: Obama overlooking legal constraints on employer mandate delay; Bush's 'unnecessary' heart procedure; discrimination against people with mental illnesses

In his Friday remarks, Mr. Obama also claimed that he had the "executive authority" for the mandate delay. But if he really believes that, then why did he say he would normally ask for a legislative "tweak." Either the fix requires legislation or it doesn't. His comments are certainly revealing about his attitudes on Presidential power and the constraints of the U.S. Constitution. Article II, Section 3 instructs him to take care that the laws be faithfully executed, not merely what he thinks is "the essence" of laws (8/10).

13 Aug 2013

Genome News and Research

ATF3 gene may be the crucial link between stress and breast cancer: Study

Scientists reveal why TB is a successful pathogen

Medical investigators discover new aspect of gene-splicing process that produces mRNA

Oxford Gene Technology releases next generation sequencing survey results

Researchers identify genome-wide locus for serious gastrointestinal condition in infants

Research suggests gene therapy approach may be feasible option to treat Rett Syndrome

Researchers create mouse models to advance the study of unusual deadly diseases

Illumina announces availability of its newest reagent kits for MiSeq benchtop sequencer

ATSP-7041 stapled peptide activates p53, suppresses tumor growth in animal models

Study provides information that validates genetic basis of adaptation to high altitudes

Mutational signatures in DNA explain genetic development, history of cancers in patients

Researchers find possible mechanism of how cellular memory works

Scientists have made breakthrough in understanding cancer-promoting action of herbal products

Study shows enhancer RNA molecules may open new avenues for gene therapy

Researchers identify clear genetic risk factors in patients with severe epilepsy

Viewpoints: Obama overlooking legal constraints on employer mandate delay; Bush's 'unnecessary' heart procedure; discrimination against people with mental illnesses

Study reveals new genetic mutations that cause epilepsy

Strategy that dismantles flu viral genome in human lung cells ensures safe research

Patients with rare epilepsy aphasia share mutations on same gene

Learning "grammar" helps determine whether gene gets switched on or not

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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