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Sangamo's SB-509 fails to meet key endpoints in Phase 2b study for diabetic neuropathy

Sangamo BioSciences, Inc. today announced that its Phase 2b study (SB-509-901) did not meet its primary or secondary clinical endpoints in subjects with moderate severity diabetic neuropathy (DN) as compared to placebo.

3 Oct 2011

Researchers identify unusual genomic architecture linked with very severe forms of disease

When cells divide normally, DNA gets copied perfectly and distributed among the daughter cells with an even hand. Occasionally though, DNA breaks during division and is rearranged, resulting in duplications or deletions of important parts of the blueprint.

3 Oct 2011

Scientists discover 16 million SNPs that associate with increased risk of ovarian cancer

Scientists at deCODE Genetics and academic collaborators from Iceland, The Netherlands, Spain and Finland today report the discovery of variants in the human genome that associate with increased risk of invasive ovarian cancer, one of the deadliest forms of cancer in women.

3 Oct 2011

WSU to help develop alternatives to petroleum-based fuels and chemicals

U.S. Department of Agriculture Secretary Tom Vilsack yesterday announced that Washington State University (WSU) will receive a five-year, $40 million grant to help develop alternatives to petroleum-based fuels and chemicals.

3 Oct 2011

Winner of 'The Voice' to perform at MMRF Fall Gala on October 29

The Multiple Myeloma Research Foundation (MMRF) announced today that Javier Colon, winner of NBC's The Voice, will join the lineup of featured artists performing a tribute concert celebrating music industry icon Stevie Wonder at the MMRF Fall Gala, to be held October 29, 2011, at the Hyatt Regency Greenwich in Old Greenwich, Connecticut.

1 Oct 2011

Scientists discover that DNA modifications in brain cells change due to stimulated brain activity

Johns Hopkins scientists investigating chemical modifications across the genomes of adult mice have discovered that DNA modifications in non-dividing brain cells, thought to be inherently stable, instead underwent large-scale dynamic changes as a result of stimulated brain activity.

1 Oct 2011

Kimmel Cancer Center at Jefferson celebrates two decades of caring and collaboration to beat cancer

From October forward, the Kimmel Cancer Center at Jefferson (KCC), a National Cancer Institute-designated cancer center, is celebrating 20 years of service to the community and the groundbreaking cancer research from the scientists and physicians who've provided an invaluable contribution to medical science and healthcare.

30 Sep 2011

Researchers develop HTGTS to map translocatome in the genome

Researchers at Children's Hospital Boston and the Immune Disease Institute (IDI) have created a method for mapping "hot spots" in the genome where chromosomes are most likely to break and recombine, knowledge that helps define the rules that govern when and where breaks occur.

30 Sep 2011

GWAS uncovers new genes associated with type 1 diabetes

The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people worldwide. The findings add to knowledge of gene networks involved in the origin of this complex disorder, in which patients depend on frequent insulin injections to control their blood sugar levels.

30 Sep 2011

New technique helps identify how RNA molecules control gene expression

A new technique developed by researchers at the Stanford University School of Medicine allows researchers to identify the exact DNA sequences and locations bound by regulatory RNAs. This information is necessary to understand how the recently identified RNA molecules control the expression of neighboring and distant genes.

30 Sep 2011

Ambry to provide CLIA-approved exome services for applications in clinical diagnostics

Ambry Genetics today announces that it is the first laboratory to provide CLIA-approved exome services for applications in clinical diagnostics. After comprehensive review by Ambry's staff of geneticists and medical directors, these results will allow clinicians to diagnose affected patients with conditions that have eluded traditional diagnostic approaches.

30 Sep 2011

Study provides insight into earliest stages of some cancers

A novel technique that enables scientists to measure and document tumor-inducing changes in DNA is providing new insight into the earliest events involved in the formation of leukemias, lymphomas and sarcomas, and could potentially lead to the discovery of ways to stop those events.

30 Sep 2011

Genetic variant may increase severity of coronary artery disease in patients with diabetes

Researchers at Washington University School of Medicine in St. Louis have identified the first genetic variant associated with severity of coronary artery disease in patients with type 2 diabetes.

29 Sep 2011

X-chromosome related microRNA may impact immunity and cancer

As anyone familiar with the phrase 'man-flu' will know women consider themselves to be the more robust side of the species when it comes to health and illness. Now new research, published in BioEssays, seems to support the idea. The research focuses on the role of MicroRNAs encoded on the X chromosome to explain why women have stronger immune systems to men and are less likely to develop cancer.

28 Sep 2011

A Daddy’s heart is healthier: Study

A new study shows that fathers are less likely to die of heart disease than men who’ve never had kids. This raises questions about a possible biological link between male infertility and overall health. Other recent studies have found a connection between testicular and prostate cancer and infertility.

27 Sep 2011

Close link between SF3B1 mutation and specific feature of myelodysplastic syndromes

Geneticists have discovered that a gene involved in the modification of ribonucleic acid (RNA) is mutated in a significant proportion of people with a collection of blood cancers called myelodysplastic syndromes.

27 Sep 2011

Scientists uncover how methylation changes can influence blood stem cell's fate

Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of Southern California (USC) have uncovered intriguing new evidence helping to explain one of the ways in which a stem cell's fate can be determined.

27 Sep 2011

Researchers identify frequent SF3B1 gene mutation in myelodysplasia

A genomic study of chronic blood cancer - a precursor to leukaemia - has discovered gene mutations that could enable diagnosis using only a blood test, avoiding the need for an invasive and painful bone marrow biopsy.

27 Sep 2011

Researchers modify HIV in a way that makes it no longer able to suppress immune system

Researchers at Johns Hopkins have modified HIV in a way that makes it no longer able to suppress the immune system. Their work, they say in a report published online September 19 in the journal Blood, could remove a major hurdle in HIV vaccine development and lead to new treatments.

27 Sep 2011

Duplication of RPS6KA3 gene produces limited family intellectual disability

The financial contributions made some years ago by individuals and public administration bodies in the telemarathon solidarity events on the Basque Public Broadcasting Corporation (EiTB) and subsequently channelled through the Basque Foundation for Health Innovation and Research (BIOEF), has resulted in undertaking successful innovative research at the Cruces Hospital near Bilbao in the Basque province of Bizkaia, describing a new syndrome of limited family intellectual disability.

26 Sep 2011

Genome News and Research

Sangamo's SB-509 fails to meet key endpoints in Phase 2b study for diabetic neuropathy

Researchers identify unusual genomic architecture linked with very severe forms of disease

Scientists discover 16 million SNPs that associate with increased risk of ovarian cancer

WSU to help develop alternatives to petroleum-based fuels and chemicals

Winner of 'The Voice' to perform at MMRF Fall Gala on October 29

Scientists discover that DNA modifications in brain cells change due to stimulated brain activity

Kimmel Cancer Center at Jefferson celebrates two decades of caring and collaboration to beat cancer

Researchers develop HTGTS to map translocatome in the genome

GWAS uncovers new genes associated with type 1 diabetes

New technique helps identify how RNA molecules control gene expression

Ambry to provide CLIA-approved exome services for applications in clinical diagnostics

Study provides insight into earliest stages of some cancers

Genetic variant may increase severity of coronary artery disease in patients with diabetes

X-chromosome related microRNA may impact immunity and cancer

A Daddy’s heart is healthier: Study

Close link between SF3B1 mutation and specific feature of myelodysplastic syndromes

Scientists uncover how methylation changes can influence blood stem cell's fate

Researchers identify frequent SF3B1 gene mutation in myelodysplasia

Researchers modify HIV in a way that makes it no longer able to suppress immune system

Duplication of RPS6KA3 gene produces limited family intellectual disability

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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