Genome Editing News and Research

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Light-activated SpyLigation can turn on proteins both inside and outside of living cells

Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail.

18 Apr 2023

Research reveals molecular features of rare mtDNA mutations

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation.

13 Apr 2023

Optimized genome-editing method opens the door to more effective treatment of genetic diseases

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes.

11 Apr 2023

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Gene editing is one of the latest breakthroughs in biology. The widely known CRISPR-Cas gene editing system provided prokaryotes (organisms that lack cell nuclei) an immunity against foreign DNA. Since the discovery of the CRISPR gene editing technology, scientists are revealing the evolution of the CRISPR-Cas proteins from their precursors.

7 Apr 2023

UW researchers engineer stem cells that do not generate dangerous arrhythmias

Researchers at the University of Washington School of Medicine in Seattle have engineered stem cells that do not generate dangerous arrhythmias, a complication that has to date thwarted efforts to develop stem-cell therapies for injured hearts.

7 Apr 2023

St. Jude computational biologists characterize the full spectrum of oncogenic fusions in pediatric cancer

The scientific foundation needed to work on curing a class of cancer-causing mutations is here, in the form of a tool from St. Jude Children's Research Hospital.

5 Apr 2023

New type of nanoparticle can deliver messenger RNA encoding useful proteins to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

30 Mar 2023

New technology can rapidly analyze the metabolic state of lipids in cells

Professor Itaru Hamachi, Lecturer Tomonori Tamura, and Assistant Professor Masaki Tsuchiya of Kyoto University have developed a new technology called O-ClickFC (Organelle-selective click labeling with flow cytometry), which can, at a very high speed, analyze the metabolic state of lipids in cells.

27 Mar 2023

Study provides evidence for a strong role of autophagy in controlling intracellular infections

Researchers at the Francis Crick Institute have found that the body's process of removing old and damaged cell parts, is also an essential part of tackling infections that take hold within our cells, like TB.

23 Mar 2023

Avanced genome editing technology could be used as a one-time treatment for CD3 delta SCID

A new UCLA-led study suggests that advanced genome editing technology could be used as a one-time treatment for the rare and deadly genetic disease CD3 delta severe combined immunodeficiency.

21 Mar 2023

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans.

17 Mar 2023

Study sheds new light on a key protein involved in the process of spermiation

In order to achieve good times in their races, many Olympic swimmers wear swimsuits that are low in water resistance.

13 Mar 2023

Scientists discover how excess oxygen changes a handful of proteins in the cells

When it comes to oxygen, you can have too much of a good thing. Breathing air that contains higher levels of oxygen than the usual 21 percent found in Earth's atmosphere can cause organ damage, seizures, and even death in people and animals, particularly if it's in excess of the body's oxygen needs.

8 Mar 2023

Common scientific method to analyze DNA in early human embryos fails to accurately reflect gene edits

A commonly used scientific method to analyze a tiny amount of DNA in early human embryos fails to accurately reflect gene edits, according to new research led by scientists at Oregon Health & Science University.

7 Mar 2023

Genome editing could help save rice crops threatened by climate change

A review of gene editing techniques suggests that the CRISPR/Cas (clustered regularly interspaced short palindromic repeats/Cas) method could be a possible 'savior' for rice crops threatened by climate change and high food demand.

3 Mar 2023

Genome editing techniques based on bacterial-artificial-chromosome in herpesvirus research

In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

28 Feb 2023

Genome editing prevents hypertrophic cardiomyopathy in mice

In a recent study published in the journal PLoS Digital Health, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows:

19 Feb 2023

Genome Editing News and Research

Light-activated SpyLigation can turn on proteins both inside and outside of living cells

Research reveals molecular features of rare mtDNA mutations

Optimized genome-editing method opens the door to more effective treatment of genetic diseases

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

UW researchers engineer stem cells that do not generate dangerous arrhythmias

St. Jude computational biologists characterize the full spectrum of oncogenic fusions in pediatric cancer

New type of nanoparticle can deliver messenger RNA encoding useful proteins to the lungs

New technology can rapidly analyze the metabolic state of lipids in cells

Study provides evidence for a strong role of autophagy in controlling intracellular infections

Avanced genome editing technology could be used as a one-time treatment for CD3 delta SCID

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

Study sheds new light on a key protein involved in the process of spermiation

Scientists discover how excess oxygen changes a handful of proteins in the cells

Common scientific method to analyze DNA in early human embryos fails to accurately reflect gene edits

Genome editing could help save rice crops threatened by climate change

Genome editing techniques based on bacterial-artificial-chromosome in herpesvirus research

Genome editing prevents hypertrophic cardiomyopathy in mice

Scientists discover a protein in the lung that blocks SARS-CoV-2 infection

The human body develops strategies to prevent the immune response from overshooting its mark

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

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