Genomic News and Research

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Overall balance of bacteria on skin may be key factor for acne development

Researchers, led by Dr Huiying Li, an associate professor of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA, used over-the-counter pore cleansing strips to obtain skin follicle samples from 72 individuals: 38 with acne and 34 who didn't have the disease.

6 Apr 2017

Attacking TERT protein may be effective approach to destroying ALM cancer cells

A team of researchers report a significant genetic association linked to an aggressive form of melanoma in a study published today in the journal Genome Research.

4 Apr 2017

Scientists develop novel technique to screen non-coding DNA of genome for diseases

Researchers have developed a method to swiftly screen the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation.

4 Apr 2017

Researchers uncover novel genetic links underlying Fuchs endothelial corneal dystrophy

Corneal diseases are among the most common causes of visual impairment and blindness, with Fuchs endothelial corneal dystrophy (FECD), a gradual swelling and clouding of the cornea, being the most common reason for eventual corneal transplants.

31 Mar 2017

Researchers shed light on genome reorganization after fertilization in single-cell mammalian embryo

Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single-cell mammalian embryo

30 Mar 2017

MGH scientists develop software that provides automated support for diagnosing cause of stroke

Determining the cause of an ischemic stroke - one caused by an interruption of blood supply - is critical to preventing a second stroke and is a primary focus in the evaluation of stroke patients. But despite that importance, physicians have long lacked a robust and objective means of doing so.

29 Mar 2017

Study explores new immunotherapy combinations to treat prostate cancer

Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune system, researchers at The University of Texas MD Anderson Cancer Center report in Nature Medicine.

29 Mar 2017

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

Charis Eng, M.D., Ph.D., of Cleveland Clinic and her team have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer. They recently published this discovery in Human Molecular Genetics.

29 Mar 2017

JAX professor receives HFSP grant for 3D genome studies of memory, learning and epilepsy

Jackson Laboratory Professor Yijun Ruan, Ph.D., a leader in the study of the three-dimensional organization of the human genome, has received a three-year grant totaling $1,050,000 from the international Human Frontier Science Program to explore the fundamental mechanics involved in memory and learning as well as epilepsy.

28 Mar 2017

Study identifies protein as potential therapeutic target for pancreatic cancer

A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five-year survival rate.

28 Mar 2017

Rogue proteins involved in breast cancer point to potential treatment options

For patients with difficult-to-treat cancers, doctors increasingly rely on genomic testing of tumors to identify errors in the DNA that indicate a tumor can be targeted by existing therapies.

28 Mar 2017

Scientists crack crystal structure of entire ZIKV NS5 protein

Zika virus (ZIKV), which causes Zika virus disease, is spread to people primarily through the bite of an infected Aedes aegypti or Aedes albopictus mosquito. An infected pregnant woman can pass ZIKV to her fetus during pregnancy or around the time of birth. Sex is yet another way for infected persons to transmit ZIKV to others.

27 Mar 2017

Scientists call for better basic-clinical genomic research collaborations

In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory, National Human Genome Research Institute and institutions across the U.S. declare in a Leading Edge commentary in Cell.

27 Mar 2017

Major grant funds research effort that seeks to understand complexity of invasive cancer

A $9.5 million, five-year grant from the National Cancer Institute (NCI) will fund an intensive multidisciplinary research effort that seeks to better understand how cancer cells reach an aggressive state and begin to damage surrounding tissue.

25 Mar 2017

Random DNA copying ‘mistakes’ account for most cancer mutations, study finds

Johns Hopkins Kimmel Cancer Center scientists report data from a new study providing evidence that random, unpredictable DNA copying "mistakes" account for nearly two-thirds of the mutations that cause cancer.

24 Mar 2017

NHGRI researchers use facial recognition software to diagnose rare genetic disease

Researchers with the National Human Genome Research Institute, part of the National Institutes of Health, and their collaborators, have successfully used facial recognition software to diagnose a rare, genetic disease in Africans, Asians and Latin Americans.

24 Mar 2017

Genome sequencing approach opens door to therapy options for rare, neglected cancers

An international team of scientists led by the Icahn School of Medicine at Mount Sinai and UConn School of Medicine have reported the results of a genome sequencing study for an extremely rare form of cancer.

23 Mar 2017

Researchers develop novel genetic score to calculate age-specific risk of Alzheimer's disease

An international team of scientists, led by researchers at University of California San Diego School of Medicine and University of California San Francisco, has developed a novel genetic score that allows individuals to calculate their age-specific risk of developing Alzheimer's disease (AD), based upon genetic information.

22 Mar 2017

Machine learning helps researchers uncover cellular control networks

The flow of information between cells in our bodies is exceedingly complex: sensing, signaling, and influencing each other in a constant flow of microscopic engagements. These interactions are critical for life, and when they go awry can lead to the illness and injury.

22 Mar 2017

Researchers develop new software tool to provide fast, accurate quantification of gene expression

A group of computational biological researchers, led by Stony Brook University's Rob Patro, an Assistant Professor in the Department of Computer Science in the College of Engineering and Applied Sciences, has developed a new software tool, Salmon — a lightweight method to provide fast and bias-aware quantification from RNA-sequencing reads.

22 Mar 2017

Genomic News and Research

Overall balance of bacteria on skin may be key factor for acne development

Attacking TERT protein may be effective approach to destroying ALM cancer cells

Scientists develop novel technique to screen non-coding DNA of genome for diseases

Researchers uncover novel genetic links underlying Fuchs endothelial corneal dystrophy

Researchers shed light on genome reorganization after fertilization in single-cell mammalian embryo

MGH scientists develop software that provides automated support for diagnosing cause of stroke

Study explores new immunotherapy combinations to treat prostate cancer

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

JAX professor receives HFSP grant for 3D genome studies of memory, learning and epilepsy

Study identifies protein as potential therapeutic target for pancreatic cancer

Rogue proteins involved in breast cancer point to potential treatment options

Scientists crack crystal structure of entire ZIKV NS5 protein

Scientists call for better basic-clinical genomic research collaborations

Major grant funds research effort that seeks to understand complexity of invasive cancer

Random DNA copying ‘mistakes’ account for most cancer mutations, study finds

NHGRI researchers use facial recognition software to diagnose rare genetic disease

Genome sequencing approach opens door to therapy options for rare, neglected cancers

Researchers develop novel genetic score to calculate age-specific risk of Alzheimer's disease

Machine learning helps researchers uncover cellular control networks

Researchers develop new software tool to provide fast, accurate quantification of gene expression

Genetics & Genomics - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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