Genomic News and Research

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Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

One of the most promising areas of cancer research is personalized therapy using precision medicine. The National Cancer Institute's NCI-MATCH is a large, ongoing clinical trial that matches tumors to therapies based on the tumor's genetic characteristics.

7 Feb 2017

Scientists find new method for identifying therapeutic targets in cancers lacking tumor suppressor genes

A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes.

7 Feb 2017

Researchers evaluate biological effects of exposure to cigarette smoke versus e-cigarette aerosols

Researchers reported changes in the expression levels of 123 genes when reconstituted lung tissue was exposed to cigarette smoke, compared to only two genes that could be confirmed following exposure to e-cigarette aerosols.

6 Feb 2017

Difference between men and women in age preferences of sexual partners smaller than earlier believed

The difference between men and women with respect to their age preferences, when it comes to sexual partners, is smaller than earlier believed.

6 Feb 2017

TGen scientists identify novel genomic mutation that causes developmental delays in children

Researchers at the Translational Genomics Research Institute have identified a genomic mutation that causes physical abnormalities and developmental delays in children.

3 Feb 2017

Common drug for autoimmune disease may increase risk of myeloid neoplasms

Mayo Clinic researchers have found that azathioprine, a drug commonly used to treat autoimmune disease, may increase the risk of myeloid neoplasms.

3 Feb 2017

Precision-medicine approach could improve accuracy of PSA-based prostate cancer screening tests

A new study led by researchers at UC San Francisco and Kaiser Permanente has identified genetic predictors of normal prostate-specific antigen (PSA) levels in healthy men, which could be used to improve the accuracy of PSA-based prostate cancer screening tests.

3 Feb 2017

Virulence of bacterial infections dependent on presence of cytotoxins, study reports

Beginning in the mid-1980s, an epidemic of severe invasive infections caused by Streptococcus pyogenes (S. pyogenes), also known as group A streptococcus (GAS), occurred in the United States, Europe, and elsewhere.

2 Feb 2017

Study finds new links between human genome and inflammation tracers

Researchers from the Research Centre of Applied and Preventive Cardiovascular Medicine at the University of Turku, Finland, have studied over ten million DNA variations and found new links between the human genome and inflammation tracers.

1 Feb 2017

Sanford clinical study exploring immunotherapy drug to treat patients with advanced esophageal cancer

A clinical trial at Sanford Health is studying if an immunotherapy drug developed by Merck might be able to treat certain patients with advanced esophageal cancer. The Merck Keynote 181 trial is now open at Sanford.

31 Jan 2017

JAX researchers unravel mechanism that enables cancer cells to survive and divide

Some cancer cells have a trick up their sleeve to avoid cell death: boosting maintenance of telomeres, the protective "end caps" on chromosomes, and a research team led by Jackson Laboratory Professor Roel Verhaak reports in Nature Genetics on a newly discovered telomere maintenance mechanism.

31 Jan 2017

Researchers develop online resource to gather, organize research information on cancer mutations

The body of knowledge on cancer genomics is massive and ever-expanding. But this wealth of potentially critical information is far less likely to be of help to patients if it is inaccessible to the doctors who treat them.

31 Jan 2017

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and develop alternative pharmacological treatment options.

31 Jan 2017

Research provides new insights into epigenetic heterogeneity of Ewing sarcoma

Tumors of the elderly, such as breast cancer and colon cancer, accumulate thousands of DNA mutations.

31 Jan 2017

Scientists decode genetic profile of rare inherited disorder that can cause genital ambiguity

A complete clinical and genetic profile of a rare inherited disorder, steroid 11-hydroxylase deficiency, which can cause genital masculinization in females, is being reported by an international group of researchers led by investigators at the Icahn School of Medicine at Mount Sinai.

30 Jan 2017

OHSU scientists uncover method for efficiently mapping genome of single cells in the body

OHSU scientists have uncovered a method for quickly and efficiently mapping the genome of single cells within the body. Their findings, to be published Jan. 30 in the journal Nature Methods, clears the way for a significant advance in precision medicine, including cancer, and many other disease areas.

30 Jan 2017

Genomic News and Research

Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

Scientists find new method for identifying therapeutic targets in cancers lacking tumor suppressor genes

Researchers evaluate biological effects of exposure to cigarette smoke versus e-cigarette aerosols

Difference between men and women in age preferences of sexual partners smaller than earlier believed

TGen scientists identify novel genomic mutation that causes developmental delays in children

Common drug for autoimmune disease may increase risk of myeloid neoplasms

Precision-medicine approach could improve accuracy of PSA-based prostate cancer screening tests

Virulence of bacterial infections dependent on presence of cytotoxins, study reports

Study finds new links between human genome and inflammation tracers

Sanford clinical study exploring immunotherapy drug to treat patients with advanced esophageal cancer

JAX researchers unravel mechanism that enables cancer cells to survive and divide

Researchers develop online resource to gather, organize research information on cancer mutations

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

Research provides new insights into epigenetic heterogeneity of Ewing sarcoma

Scientists decode genetic profile of rare inherited disorder that can cause genital ambiguity

OHSU scientists uncover method for efficiently mapping genome of single cells in the body

University of Freiburg offers infrastructure and data services to support life science research

ACMG issues new Points to Consider statement on potential clinical application of genome editing

Missing gene may cause kidney and urinary tract defects in people with DiGeorge syndrome

Portable DNA sequencing device brought into North Hospitals to fight against anti-microbial resistance

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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