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Mutations linked to endometrial cancer can be detected in uterine lavage fluid, study reveals

Mutations that have been linked to endometrial cancer can be found in the uterine lavage fluid of pre- and post-menopausal women both with and without detectable cancer, according to a study published in PLOS Medicine by John Martignetti from the Icahn School of Medicine at Mount Sinai, New York, USA, and colleagues.

28 Dec 2016

Researchers explore how neuronal activity influences CREB dynamics

Neuronal activity mediates the formation of neuronal circuits in the cerebral cortex. These processes are regulated by the transcription factor CREB, which regulates gene expression in neuronal activity-dependent processes.

27 Dec 2016

Potential drug could become first effective treatment option for Prader-Willi syndrome

Duke Health researchers have identified a drug-like small molecule that, in animal experiments, appears to be an effective treatment for a genetic disorder called Prader-Willi syndrome.

27 Dec 2016

Genomic sequencing reveals new insights into major shigellosis outbreaks in California

In a study that could have significant impact on how disease outbreaks are managed, researchers at UC Davis and the California Department of Public Health have sequenced and analyzed genomes from Shigella sonnei (S. sonnei) bacteria associated with major shigellosis outbreaks in California in 2014 and 2015.

23 Dec 2016

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

An international team of scientists has discovered that the gene, OGDHL, a key protein required for normal function of the mitochondria -- the energy-producing factory of the cell -- and its chaperone, nardilysin (NRD1) are linked to progressive loss of neurological function in humans.

22 Dec 2016

New computational tool can predict personal cancer driver genes to optimize treatment

Columbia University Medical Center researchers have created a computational tool that can rapidly predict which genes are implicated in an individual's cancer and recommend treatments.

22 Dec 2016

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Scientists from the Florida campus of The Scripps Research Institute have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.

22 Dec 2016

Agendia data reveals impact of MammaPrint on adjuvant treatment decisions in breast cancer patients

Agendia, Inc., a world leader in personalized medicine and molecular cancer diagnostics, has presented new prospective data demonstrating the strong impact of its 70-Gene Breast Cancer Recurrence assay, MammaPrint, and the corresponding 80-Gene Molecular Subtyping Assay BluePrint, in clinical decision-making for patients with early-stage breast cancer in Germany.

22 Dec 2016

Oncotype DX test can help guide treatment decisions and enable personalized care before breast cancer surgery

New data presented at the 2016 San Antonio Breast Cancer Symposium (SABCS) demonstrate that analyzing tumor biology with the Oncotype DX test can identify patients unlikely to benefit from chemotherapy prior to breast cancer surgery (neoadjuvant setting) and guide treatment decisions without compromising outcomes.

22 Dec 2016

Novel genomics model allows personalized approach to radiation therapy

Cancer therapeutics is currently in the era of precision medicine - personalized medicine for individual patients based on their tumor biology.

20 Dec 2016

Researchers use DNA markers to differentiate harmless species from deadly bacteria

The virulent pathogen that causes the disease tularemia, or "rabbit fever," was weaponized during past world wars and is considered a potential bioweapon.

20 Dec 2016

AMP publishes joint guidelines for interpretation, reporting of sequence variants in cancer

The Association for Molecular Pathology (AMP), the premier global, non-profit molecular diagnostics professional society, today published guideline recommendations for both clinical laboratory professionals and oncologists that assess the status of next-generation sequencing (NGS)-based cancer tests and establish standardized classification, annotation, interpretation, and reporting conventions for somatic sequence variants.

17 Dec 2016

Mayo Clinic creates genetic test to help guide diagnosis, treatment of lymphoma patients

Mayo Clinic has created a genetic test to help guide diagnosis and treatment of patients with diffuse large B-cell lymphoma, the most common type of non-Hodgkin's lymphoma.

16 Dec 2016

Researchers develop new method to identify antigens for cancer treatment

New cancer therapies harness the immune system to fight tumors. One of the main principles behind these therapies is to find out precisely which molecules on cancer cells trigger an immune response.

16 Dec 2016

Genes that control immune system play key role in predisposition to HPV-related tumors

A number of genetic variants associated with susceptibility to oral cavity and pharyngeal cancer have been described in an international study published in the journal Nature Genetics.

16 Dec 2016

Researchers identify new gene fusions and mutations linked to subset of GIST patients

In recent years, researchers have identified specific gene mutations linked to gastrointestinal stromal tumors (GIST), which primarily occur in the stomach or small intestine, with 5,000 to 6,000 new cases per year in the United States.

16 Dec 2016

Scientists develop first functional biological pacemaker from human stem cells

Scientists from the McEwen Centre for Regenerative Medicine, University Health Network, have developed the first functional pacemaker cells from human stem cells, paving the way for alternate, biological pacemaker therapy.

15 Dec 2016

Study identifies recurrent genomic alterations in subset of breast cancer

A genomic analysis study by Rutgers Cancer Institute of New Jersey investigators and other colleagues has identified recurrent genomic alterations in a subset of breast cancer that are typically associated with a form of thyroid cancer and an intestinal birth defect known as Hirschsprung disease.

9 Dec 2016

GWAS identifies genomic locations linked to personality traits and psychiatric disorders

A meta-analysis of genome-wide association studies has identified six loci or regions of the human genome that are significantly linked to personality traits, report researchers at University of California San Diego School of Medicine in this week's advance online publication of Nature Genetics.

9 Dec 2016

Duke researchers develop new cell-based drug screening test for dystonia

Duke University researchers have identified a common mechanism underlying separate forms of dystonia, a family of brain disorders that cause involuntary, debilitating and often painful movements, including twists and turns of different parts of the body.

8 Dec 2016

Genomic News and Research

Mutations linked to endometrial cancer can be detected in uterine lavage fluid, study reveals

Researchers explore how neuronal activity influences CREB dynamics

Potential drug could become first effective treatment option for Prader-Willi syndrome

Genomic sequencing reveals new insights into major shigellosis outbreaks in California

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

New computational tool can predict personal cancer driver genes to optimize treatment

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Agendia data reveals impact of MammaPrint on adjuvant treatment decisions in breast cancer patients

Oncotype DX test can help guide treatment decisions and enable personalized care before breast cancer surgery

Novel genomics model allows personalized approach to radiation therapy

Researchers use DNA markers to differentiate harmless species from deadly bacteria

AMP publishes joint guidelines for interpretation, reporting of sequence variants in cancer

Mayo Clinic creates genetic test to help guide diagnosis, treatment of lymphoma patients

Researchers develop new method to identify antigens for cancer treatment

Genes that control immune system play key role in predisposition to HPV-related tumors

Researchers identify new gene fusions and mutations linked to subset of GIST patients

Scientists develop first functional biological pacemaker from human stem cells

Study identifies recurrent genomic alterations in subset of breast cancer

GWAS identifies genomic locations linked to personality traits and psychiatric disorders

Duke researchers develop new cell-based drug screening test for dystonia

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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