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Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia (AML) patients with a mutant Ikaros zinc finger protein 1 (IKZF1).

2 Feb 2023

MD Anderson and Federation Bio collaborate to design and manufacture a synthetic microbial consortium

The University of Texas MD Anderson Cancer Center and Federation Bio today announced a strategic collaboration to design and manufacture a complex, synthetic microbial consortium with the goal of expanding the number of cancer patients who respond to immunotherapy.

1 Feb 2023

Could novel lineages eventually dominate the viral population?

A new study puts forward a bottom-up approach to quickly predict whether a lineage will dominate the viral population, at a particular geographical location.

1 Feb 2023

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Scientists review existing literature to evaluate the advancements in genomic and exome sequencing for the accurate detection of undiagnosed syndromes.

1 Feb 2023

Study demonstrates intrahost MPXV variation within a single lesion

Researchers reported on the clinical and molecular characteristics of MPXV infections in Finland.

31 Jan 2023

Novel papillomaviruses identified in Malayan and Chinese pangolins

Researchers identify two novel lineages of papillomaviruses by mining the genome data of Chinese and Malayan pangolins.

26 Jan 2023

Study identifies the DNA roots of resistance to targeted cancer therapy

A new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics.

26 Jan 2023

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

26 Jan 2023

Study reveals the inevitability of Zika virus dumbbell-1 structure for viral pathogenesis

In a recent study posted to the bioRxiv* preprint server, researchers designed two dumbbell-1 (DB-1) mutant Zika virus (ZIKV) infectious clones termed ZIKV-TL.PK and ZIKV-p.2.5’.

26 Jan 2023

Researchers report on a genome-wide reconstruction of human microbes to develop personalized therapies

Researchers reported on AGORA2, an expansion of their previously published resource, AGORA, of genomewide metabolic reconstructions of human intestinal microbes.

26 Jan 2023

Do individuals with acute attitudes toward science over-estimate their understanding of scientific matters?

Researchers investigated whether individuals with extreme attitudes, negative or positive, show a greater likelihood of believing that they understand science and whether the trends in attitudes were contingent on technological specifications.

26 Jan 2023

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation technology to study CTCF.

26 Jan 2023

Scientists illuminate how blood cancer treatments can lead to therapy-related myeloid neoplasms

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have illuminated how treatments for multiple myeloma and other aggressive blood cancers can lead to future malignancies, called therapy-related myeloid neoplasms (tMNs).

25 Jan 2023

Genomic screening can facilitate early detection of thyroid cancer in patients with RET gene variants

Population-based genomic screening can facilitate early detection of medullary thyroid cancer (MTC) in patients with variants in the RET gene, a new Geisinger study found.

25 Jan 2023

Deaf patients break barriers by co-designing their own care with University of Utah Health

Navigating health care is hard enough when English is your first language-;imagine the difficulty when American Sign is your first language.

25 Jan 2023

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

25 Jan 2023

A slight increase in Mpox cases across the globe, along with an increase in deaths

The WHO discusses genomic sequencing of the Mpox virus, in addition to providing public and clinical health links between HIV and Mpox.

24 Jan 2023

Study shows spatial organization in tumor cells

Researchers investigated whether the observed tumor cellular heterogeneity and architecture result from stochastic and chaotic events, or whether there is more coordination in the histopathological chaos of cancer.

24 Jan 2023

Researchers identify a key host-cell player in COVID-19 infections

Researchers at University of California San Diego and UC Riverside have further elucidated the molecular pathway used by the SARS-CoV-2 virus to infect human lung cells, identifying a key host-cell player that may prove a new and enduring therapeutic target for treating COVID-19.

24 Jan 2023

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Many life-saving drugs directly interact with DNA to treat diseases such as cancer, but scientists have struggled to detect how and why they work – until now.

23 Jan 2023

Genomic News and Research

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

MD Anderson and Federation Bio collaborate to design and manufacture a synthetic microbial consortium

Could novel lineages eventually dominate the viral population?

Effectiveness of exome and genome sequencing to detect undiagnosed syndromes

Study demonstrates intrahost MPXV variation within a single lesion

Novel papillomaviruses identified in Malayan and Chinese pangolins

Study identifies the DNA roots of resistance to targeted cancer therapy

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

Study reveals the inevitability of Zika virus dumbbell-1 structure for viral pathogenesis

Researchers report on a genome-wide reconstruction of human microbes to develop personalized therapies

Do individuals with acute attitudes toward science over-estimate their understanding of scientific matters?

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

Scientists illuminate how blood cancer treatments can lead to therapy-related myeloid neoplasms

Genomic screening can facilitate early detection of thyroid cancer in patients with RET gene variants

Deaf patients break barriers by co-designing their own care with University of Utah Health

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

A slight increase in Mpox cases across the globe, along with an increase in deaths

Study shows spatial organization in tumor cells

Researchers identify a key host-cell player in COVID-19 infections

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

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