Genotyping News and Research

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Computational study identifies key areas of the SARS-CoV-2 genome prone to mutation

By retrieving 329,942 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) records from the GISAID database, researchers from a software company in Cambridge described genetic variability of SARS-CoV-2 in order to inform further studies. Their findings are currently available on the bioRxiv* preprint server while it undergoes peer review.

9 Aug 2021

Researchers uncover genetic markers associated with COVID-19 infection risk and severity

An international collaboration uncovers several genetic markers associated with SARS-CoV-2 infection and COVID-19 severity.

8 Jul 2021

Rare genetic variants have a big impact on the risk of developing type 2 diabetes

Scientists at the University of Cambridge have identified rare genetic variants - carried by one in 3,000 people - that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect.

7 Jul 2021

A new study reveals unintended CRISPR/Cas9 editing events

A recent study by researchers from Sweden and the United Kingdom shows that CRISPR/Cas9-based genomic engineering can prompt unwanted on-target effects, and highlights the complexity of human DNA repair mechanisms in the presence of the powerful prokaryotic Cas9 nuclease. The paper is currently available on the bioRxiv* preprint server.

4 Jul 2021

FDA's new Cyclospora Prevention, Response and Research Action Plan released

As part of our ongoing efforts to combat foodborne illness and aligned with our New Era of Smarter Food Safety initiative, today, the U.S. Food and Drug Administration released the Cyclospora Prevention, Response and Research Action Plan.

1 Jul 2021

AMSBIO offers an extensive collection of normal and disease state FFPE tissue blocks

AMSBIO has established an unmatched commercial biorepository and procurement network that includes a large selection of fully characterized and annotated Formalin-Fixed Paraffin-Embedded tissue blocks to help streamline your research.

From AMS Biotechnology 1 Jul 2021

Gene variant in African Americans contributes to unnecessary bone marrow biopsies

A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine.

28 Jun 2021

Benefits and Challenges for XpressAmp™ Direct Amplification Reagents

News-Medical interviews Curtis Knox, Sr Strategic Portfolio Manager at Promega, about using the XpressAmp™ for the direct amplification of reagents.

From Promega Corporation 15 Jun 2021

AMP’s new consensus can promote standardization of PGx gene/allele testing, improve patient care

The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP2D6 assays, promote standardization of testing across different laboratories and improve patient care

11 Jun 2021

Study reveals four coagulation measures associated with migraine susceptibility

Nearly 15 percent of the U.S. population experiences migraine. One subtype of migraine that is not well understood is migraine with aura (MA).

19 May 2021

Researchers develop novel test that screens for SARS-CoV-2 variants of concern

A team of scientists from the United States has recently developed a single-tube duplex molecular assay for rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants containing E484K and N501Y spike mutations.

30 Mar 2021

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Previous research identified the interferon-responsive OAS1 gene as a risk gene for Alzheimer's disease. OAS1 is an enzyme that binds to double-stranded RNA and induces the conformation to create oligoadenylates. They also activate RNase L to break down RNA.

23 Mar 2021

More diverse SARS-CoV-2 variants identified within infected children than in adults

A new study describes the identification of multiple circulating variants of SARS-CoV-2 during this early pandemic period from Asia and Europe. In addition, there were multiple local introductions of different variants, that resulted in multiple waves of transmission.

23 Feb 2021

Why the U.S. is underestimating Covid reinfection

Kaitlyn Romoser first caught Covid-19 in March, likely on a trip to Denmark and Sweden, just as the scope of the pandemic was becoming clear. Romoser, who is 23 and a laboratory researcher in College Station, Texas, tested positive and had a few days of mild, coldlike symptoms.

8 Feb 2021

Researchers discover many genetic markers related to bone mineral accrual

A multidisciplinary team of researchers led by Children's Hospital of Philadelphia (CHOP) has discovered several genetic markers associated with bone mineral accrual, which could ultimately help identify causes of eventual osteoporosis earlier in life through genetic testing.

6 Jan 2021

Researchers recommend strategies for improving the accuracy of polygenic risk scores

As the consumer genetics industry rapidly expands, more and more people are turning to DNA-based services to learn their risk of developing a wide range of diseases.

5 Dec 2020

Guidelines for accurate amplicon-based sequencing of SARS-CoV-2

A new study describes much-needed guidelines for reliable viral sequencing, validated in a large group of clinical samples.

3 Dec 2020

UC researcher receives $443,000 NIH grant to study antiviral drugs

University of Cincinnati pharmaceutical sciences researcher Bingfang Yan, DVM, has received a $443,000 grant from the National Institutes of Health to study how common medicines against viral infections are genetically impacted for therapeutic effectiveness and safety through metabolic conversions in the body.

18 Nov 2020

UCLA Health collaborates with Regeneron Genetics Center to bring genomic medicine to patients

UCLA Health has entered into a collaborative research agreement with the Regeneron Genetics Center (RGC) to provide whole exome sequencing for 150,000 UCLA Health patients.

16 Nov 2020

Study identifies genetic risk for fatal blood clots in IBD patients

Blood clots are the biggest cause of death in patients with inflammatory bowel disease (IBD) ─ ulcerative colitis or Crohn's disease. In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases.

11 Nov 2020