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Researchers assess UK biobank genome sequences

In a new study, researchers analyzed 150,119 genome sequences from the United Kingdom Biobank (UKB).

26 Jul 2022

Newly characterized stem cell self-renewal factor enables continuous sperm production

Unlike women, who are born with all the eggs they'll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, which give rise to sperm.

15 Jul 2022

Researchers gain new insight into retroviral establishment in the koala genome

Historic virus infections can be traced in vertebrate genomes. For millions of years, these genomes have been repositories for retroviruses that incorporated their code into germline cells and were inherited as endogenous retroviruses (ERVs).

13 Jun 2022

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

Single-cell RNA-sequencing (scRNA-seq) shows which genes are turned on in a cell and what their level of transcription is. This allows in-depth assessment of the biology of individual cells, and detection of changes that may indicate disease.

31 May 2022

Penn biologists show evidence of a two-sided genomic arms race involving repetitive DNA

Biological arms races are commonplace in nature. Cheetahs, for example, have evolved a sleek body form that lends itself to rapid running, enabling them to feast upon similarly speedy gazelles, the fastest of which may evade predation.

27 May 2022

Exploring cross-neutralizing anti-SARS-CoV-2 antibody responses among the general population

Researchers performed a molecular analysis of cross-reactive antibodies targeted against the receptor-binding domain of SARS-CoV-2 strains among the general population.

20 May 2022

Male pheromones may be the fountain of youth for aging females' eggs

Male pheromones just might be the fountain of youth for aging female animals' eggs, according to a new Northwestern University study.

19 May 2022

Discovery of a potent SARS-CoV-2 RBD specific human monoclonal antibody

A recent article posted to the bioRxiv* preprint server demonstrated structural underpinnings of the neutralization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants by 002-S21F2, an extensive SARS-CoV-2 neutralizing antibody.

18 May 2022

Researchers explore broad-based immunity against potentially pandemic-causing viruses

A new study focused on broad-spectrum immunity against viruses that harbor the potential for generating a pandemic involving humans, especially those with the potential for zoonotic spillover.

17 May 2022

Unique antibody responses after third COVID-19 mRNA vaccination

Researchers observed that a third messenger ribonucleic acid COVID-19 vaccine elicits a unique antibody response.

16 May 2022

Hypermutation in children could be linked to the biological father receiving chemotherapy treatments

Some rare cases of higher genetic mutation rates in children, known as hypermutation, could be linked to the father receiving certain chemotherapy treatments, new research has found.

11 May 2022

Funding innovative technologies to revolutionize cancer research

In this interview, News-Medical interviews Michael Weingarten about his work as a director of the Small Business Innovation Research Development Center, helping to fund highly-innovative technologies that are revolutionizing cancer research.

3 May 2022

Species differences in somatic mutations shed light on aging

A recent study published in the journal Nature aimed to elucidate, through a comparative analysis, the diversity in mutagenesis across different species, and the long-established hypothesis regarding evolution in the rates of somatic mutation, as well as their role in cancer and aging.

25 Apr 2022

Could DNA be linked to Premature Aging in Cancer Survivors?

In this interview, we speak to Dr. Wang about his latest research that investigated accelerated aging in childhood cancer survivors and the underlying genetics causing this.

22 Apr 2022

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers -; ATR inhibitor elimusertib and PARP inhibitor AZD5305 -; are safe and clinically beneficial in treating patients with advanced solid tumors.

11 Apr 2022

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Germline News and Research

Researchers assess UK biobank genome sequences

Newly characterized stem cell self-renewal factor enables continuous sperm production

Researchers gain new insight into retroviral establishment in the koala genome

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

Penn biologists show evidence of a two-sided genomic arms race involving repetitive DNA

Exploring cross-neutralizing anti-SARS-CoV-2 antibody responses among the general population

Male pheromones may be the fountain of youth for aging females' eggs

Discovery of a potent SARS-CoV-2 RBD specific human monoclonal antibody

Researchers explore broad-based immunity against potentially pandemic-causing viruses

Unique antibody responses after third COVID-19 mRNA vaccination

Hypermutation in children could be linked to the biological father receiving chemotherapy treatments

Funding innovative technologies to revolutionize cancer research

Species differences in somatic mutations shed light on aging

Could DNA be linked to Premature Aging in Cancer Survivors?

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

Primordial germ cell-like cells generated from rat stem cells enable the birth of normal offspring

Pre-existing memory B cell dynamics during SARS-CoV-2 Omicron breakthrough infection

Study confirms no preexisting B-cell immunity against SARS-CoV-2 in pre-pandemic samples

Study investigates germinal center of antibody-mediated immunity against SARS-CoV-2

Hasret Altan-Martin

Speeding Up Sample Preparation to Accelerate Analytical Chemistry

Ask the Expert: 7 Questions about Colorectal Cancer & Non-invasive Fecal DNA Testing

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