Ghrelin News and Research

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Ghrelin is a hormone produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas that stimulates appetite. Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. Ghrelin is also produced in the hypothalamic arcuate nucleus where it stimulates the secretion of growth hormone from the anterior pituitary gland.

A deep look into hormone-producing cells of the gut

Researchers from the Hubrecht Institute and Utrecht University generated an in-depth description of the human hormone-producing cells of the gut, in a large collaborative effort with other research teams. The results are presented in the scientific journal Cell on the 13th of May.

13 May 2020

Shift workers at increased risk for sleep disorders and metabolic syndrome

Shift workers are at a significantly increased risk for sleep disorders and metabolic syndrome, which increases a person's risk for heart disease, stroke and type 2 diabetes mellitus.

3 Feb 2020

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

One in every 15,000 children is affected by Prader-Willi syndrome (PWS), a complex, genetic endocrine condition caused by a disorder of chromosome 15. It's non-inheritable, meaning the condition isn't passed down from a family member.

3 Jan 2020

Cancer risk reduces to half with over 20% weight loss in post- bariatric surgery patients

Patients with severe obesity who had bariatric or weight-loss surgery and lost more than 20% of their total weight were 50% less likely to develop cancer compared to patients who did not have as much weight loss after surgery, according to a new study presented today by Oregon Health & Science University researchers at the 36th American Society for Metabolic and Bariatric Surgery Annual Meeting at ObesityWeek 2019.

5 Nov 2019

Fasting may increase motivation for exercise by surging "hunger hormone" ghrelin

Researchers have found that when mice are provided with limited access to food, the levels of food and satiety hormone ghrelin rises. This causes increase in motivation to exercise. This may translate to more exercise motivation for humans on intermittent fasting say the researchers.

21 Oct 2019

'Weight cycling' may provide metabolic health benefits

Repeatedly losing and regaining weight may lead to improved insulin levels and lower body fat percentages in the long term, even during weight regain phases.

10 Sep 2019

Resistance to 'hunger hormone' linked with cognitive impairments and memory loss

Scientists at The University of Texas at Dallas have found evidence suggesting that resistance to the "hunger hormone" ghrelin in the brain is linked to the cognitive impairments and memory loss associated with Alzheimer's disease.

4 Sep 2019

Meal timing strategies may help curb appetite and burn more fat

Researchers at the University of Alabama at Birmingham have discovered that meal timing strategies like intermittent fasting or eating earlier in the daytime - appear to help people lose weight.

24 Jul 2019

Ultra-Processed foods delay satiety, increase food intake and weight gain

Eating highly processed foods could be associated with weight gain finds a new study. The study was published in the latest issue of Cell Metabolism and is titled, “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.”

19 May 2019

Eat intuitively, not restrictively

Listening to the body's cues and acting on these cues, instead of ignoring them, may improve diet success, according to researchers.

5 Apr 2019

Evening exercise does not negatively affect sleep, may also reduce hunger

Must cook dinner. Need to pick the kids up from school. Have to catch up on my favorite TV series. Live too far from the gym. Any of these sound familiar? With growing time demands, many middle-aged adults are finding time to engage in exercise increasingly difficult.

21 Feb 2019

Study describes mechanism that makes people more vulnerable to hunger-causing stimuli

The holiday season is a hard one for anyone watching their weight. The sights and smells of food are hard to resist.

13 Dec 2018

Experts debate over whether gut or brain is more important in regulating appetite

Whether gut or brain hormones are more important for the regulation of appetite and metabolism is not clearly defined. Imbalances in the control of appetite and metabolism can lead to obesity and diabetes, which have a negative impact on people's health and healthcare costs.

19 Nov 2018

Researchers explore role of dietary composition on energy expenditure

The researchers say this effect may improve the success of obesity treatment, especially among people with high insulin secretion (insulin level 30 minutes after consuming a standard amount of glucose).

14 Nov 2018

Weight loss success associated with brain areas involved in self-control

New research suggests that higher-level brain functions have a major role in losing weight. In a study among 24 participants at a weight-loss clinic, those who achieved greatest success in terms of weight loss demonstrated more activity in the brain regions of the lateral prefrontal cortex associated with self-control.

19 Oct 2018

Ghrelin News and Research

Further Reading

A deep look into hormone-producing cells of the gut

Shift workers at increased risk for sleep disorders and metabolic syndrome

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

Cancer risk reduces to half with over 20% weight loss in post- bariatric surgery patients

Fasting may increase motivation for exercise by surging "hunger hormone" ghrelin

'Weight cycling' may provide metabolic health benefits

Resistance to 'hunger hormone' linked with cognitive impairments and memory loss

Meal timing strategies may help curb appetite and burn more fat

Ultra-Processed foods delay satiety, increase food intake and weight gain

Eat intuitively, not restrictively

Evening exercise does not negatively affect sleep, may also reduce hunger

Study describes mechanism that makes people more vulnerable to hunger-causing stimuli

Experts debate over whether gut or brain is more important in regulating appetite

Researchers explore role of dietary composition on energy expenditure

Weight loss success associated with brain areas involved in self-control

Study: Neural signal that urges to eat overpowers the one that says to stop

Animal studies reveal brain changes responsible for appetite effects of cannabis

Hunger hormones could be key to new treatments for drug, alcohol addiction

Researchers identify new region in mouse brain that affects appetite and body weight

URI researchers working to develop novel medication to treat alcohol use disorder

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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