Glioblastoma News and Research

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Glioblastoma is the most aggressive and malignant form of glioma, a type of primary brain cancer. Surgery is often used to treat gliomas, along with radiation. However, since surgery and radiation fail to cure the disease, doctors may turn to additional radiation or chemotherapy. In early stages glioblastoma tumors often grow without symptoms and therefore can become quite large before symptoms arise. When the tumor becomes symptomatic, tumor growth is usually very rapid and is accompanied by altered brain function, and if left untreated the disease becomes lethal. Although primary treatment is often successful in temporarily stopping the progression of the tumor, glioblastomas almost always recur and become lethal.

Scientists use advanced imaging to track brain tumor 'turncoats'

Glioblastomas, the deadliest type of brain tumor in adults, attract "turncoats." These are macrophages, a type of immune cell, which promote tumor progression and mask tumors from the immune system's scrutiny.

26 Jun 2019

Study calls for more aggressive treatments to improve 5-year survival in glioblastoma patients

Despite improvements in median and short-term survival rates for patients with glioblastoma, the most common brain tumor in adults, the percentage of patients achieving five-year survival remains low, according to new Mayo Clinic research.

23 Jun 2019

Study emphasizes need for more aggressive treatments for glioblastoma patients

20 Jun 2019

Researchers exploit nanoparticles to develop test for early detection of different diseases

Investigators from Brigham and Women's Hospital are taking advantage of a unique phenomenon of nanoparticles to develop a test for early detection of different types of diseases, including cancer.

17 Jun 2019

Researchers identify effective drug combinations for malignant brain tumor in mice

Usually, scientists study the molecular biology of cancer to find new treatments, but sometimes, it is the other way round: when trying to find new treatments, scientists find key information on cancer biology.

14 Jun 2019

New approach could help in treating brain tumors, other rare cancers

Large randomized clinical trials can uncover biomarkers that indicate which cancer treatments are likely to work best for individual patients. But it's been challenging to find these biomarkers in rarer cancers where such robust data aren't available.

13 Jun 2019

Novel agent shown to have dual mechanism of action to eliminate cancer

Results from a study spearhead by researchers at the Vall d´Hebron Institute of Oncology (VHIO), show that the blockade of the multi-functional cytokine LIF induces tumor-infiltrating T Cells to hone in on and eliminate cancer.

11 Jun 2019

Researchers identify macrophages' pathway to nurture PTEN-deficient glioblastoma

A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Cell.

11 Jun 2019

Tumor-fighting combination targets aggressive form of brain cancer

Researchers have paired a specialized diet and a tumor-fighting drug and found the non-toxic combination helps to destroy the two major cells found in an aggressive form of brain cancer, the team reports in the online edition of the Nature group journal Communications Biology.

31 May 2019

Cancer stem cells adapt to environmental conditions and undergo reversible transformations

Until now, researchers have assumed that the growth of solid tumors originates from cancer stem cells characterized by specific surface markers, which develop in a fixed, hierarchical order.

25 May 2019

Small molecule drug could be an effective strategy to treat glioblastoma

A team of researchers have published in the International Journal of Oncology that RITA, a drug able to reactivate the oncosuppressor function of p53, could be an effective strategy to treat glioblastoma.

21 May 2019

Study uncovers Achilles' heel of lethal brain tumor

Glioblastoma is the most prevalent and also the most lethal type of brain tumor in adults, with no curative treatment currently available.

10 May 2019

Scientists unravel mechanism of action of antitumor drug used to treat glioblastoma

Glioblastoma is an incurable type of brain tumor that is frequently associated with mutations in the epidermal growth factor receptor.

3 May 2019

Johns Hopkins researchers uncover role of neurotransmitter in the spread of aggressive cancers

Using human cancer cells, tumor and blood samples from cancer patients, researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter in the spread of aggressive cancers. Neurotransmitters are chemical "messengers" that transmit impulses from neurons to other target cells.

25 Apr 2019

Researchers are developing brand-new method to cure brain tumors

Scientists from Far Eastern Federal University in cooperation with colleagues from Blokhin Russian Cancer Research Center, Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors.

22 Apr 2019

Analysis of bright spot in confocal microscopy images to diagnose brain tumors

Photodynamic diagnosis using 5-aminolevulinic acid (5-ALA) is now widely used for neurosurgical resection of brain tumors.

12 Apr 2019

UB researchers develop new method to more accurately predict tumor growth rates

University at Buffalo researchers have developed a new method to more accurately predict tumor growth rates, a crucial statistic used to schedule screenings and set dosing regimens in cancer treatment.

4 Apr 2019

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against the deadly brain tumor.

28 Mar 2019

City of Hope exhibits current studies and data on cancer therapies at AACR

City of Hope, a world-renowned independent research and treatment center for cancer and diabetes, will showcase ongoing studies and data on chimeric antigen receptor T cell therapy, immunotherapy against solid tumors and more at the American Association for Cancer Research annual meeting from March 29 through April 3 in Atlanta.

22 Mar 2019

Ludwig scientists to share advances in cancer research at AACR Annual Meeting 2019

Ludwig Cancer Research released today the full breadth of findings to be presented by Ludwig researchers at this year's American Association for Cancer Research (AACR) Annual Meeting in Atlanta, Ga., March 29 - April 3, 2019.