Glucagon News and Research

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Study could offer a new way to treat Type 1 and Type 2 diabetes

Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study.

1 Mar 2021

Study shows reliability and robustness of injectable anti-obesity medication

A second study of the injectable anti-obesity medication, semaglutide, has confirmed the large weight losses reported in a study earlier this month, establishing the reliability and robustness of this new drug.

24 Feb 2021

Study explains why antipsychotic medications lead to weight gain, promote metabolic syndrome

Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and develop prediabetes and hyperinsulemia?

15 Feb 2021

Study identifies new therapeutic targets for treatment of obesity and type 2 diabetes

The GIP receptor in the central nervous system plays a crucial role in the regulation of body weight and food intake.

10 Feb 2021

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

A new study by researchers in China and the U.S. describes a round-up of the effects of commonly used hypoglycemic drugs on the outcomes of COVID-19 in diabetic patients.

1 Feb 2021

Pancreatic β cell-derived exosomal miR-29s manipulate glucose homeostasis

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs).

22 Jan 2021

FDA approves first generic glucagon for injection to treat severe hypoglycemia

Today, the U.S. Food and Drug Administration approved the first generic of glucagon for injection USP, 1 mg/vial packaged in an emergency kit, for the treatment of severe hypoglycemia (very low blood sugar), which may occur in patients with diabetes mellitus.

28 Dec 2020

New drug combination improves blood glucose control and weight loss in mice

Scientists have shown that adding an experimental cancer drug to a widely used diabetes treatment improves blood glucose control and weight loss in mice, according to a study published today in eLife.

22 Dec 2020

Research uncovers novel anti-craving mechanism to treat cocaine relapse

Cocaine continues to be one of the most commonly abused illicit drugs in the United States. Pre-clinical literature suggests that targeting glucagon-like peptide-1 receptors (GLP-1Rs) in the brain may represent a novel approach to treating cocaine use disorder.

7 Dec 2020

Study explores connection between internal biological clocks and beta cell regeneration

Certain parts of our body, such as the skin or liver, can repair themselves after a damage. Known as cell regeneration, this phenomenon describes how cells that are still functional start to proliferate to compensate for the loss.

12 Nov 2020

Novel, highly specific treatment method for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine.

9 Nov 2020

Drug combo for Type 2 diabetes continues to stay effective after two years of treatment

Patients with Type 2 diabetes often take metformin as first-line therapy to help stabilize their blood glucose.

2 Nov 2020

Study indicates the relationship between SARS-CoV-2 viral infection and diabetes

It has recently been described that infection by some enteroviruses - a genus of viruses that commonly cause diseases of varying severity - could potentially trigger diabetes, although its direct effect 'in vivo' as well as its mechanism of action at the molecular level were unknown.

21 Oct 2020

Survival probabilities are higher in patients who underwent complex pancreatic surgery

For certain surgical procedures, can a correlation be shown between the volume of services provided per hospital and the quality of treatment results?

6 Oct 2020

Newer Type 2 diabetes medications could reduce kidney, heart disease risks

Two newer groups of medications prescribed primarily for Type 2 diabetes treatment (SGLT2 inhibitors and GLP-1 receptor agonists) could significantly reduce risks associated with chronic kidney disease (CKD) and heart disease.

28 Sep 2020

Glucagon resistance: A new biological concept in the fight against diabetes

Researchers from the University of Copenhagen are introducing a new biological concept in the fight against diabetes: glucagon resistance.

17 Sep 2020

Study shows fatty liver disease is a significant risk factor for COVID-19 hospitalization

A recent observational study by US researchers reveals that individuals with non-alcoholic fatty liver disease and steatohepatitis have increased odds of hospitalization due to coronavirus disease (COVID-19); conversely, metabolic surgery was found to be protective against the admission of infected individuals. The study is currently available on the medRxiv* preprint server.

3 Sep 2020

Negligible ACE2 expression in human beta-cells

Now, a new study published on the preprint server bioRxiv reports that even though the fatality rate is significantly higher in diabetics, there is no evidence that this is due to direct viral infection of pancreatic beta cells, which produce the key hormone in glucose homeostasis, namely insulin.

1 Sep 2020

New approach to combination drug design could be applied to disease therapies beyond diabetes

Biomedical engineers at Duke University have shown that the efficacy of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a heat-sensitive tether rather than simply concurrently administered.

27 Aug 2020

Novel drug candidate offers a major advance in the treatment for diabetes

The University of Alabama at Birmingham and Southern Research have discovered a new drug candidate that offers a major advance in the treatment for diabetes.

28 Jul 2020