Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).
Nearly 1.6 billion people worldwide suffer from anemia, and for the first time new research points to how resistance emerges to the drug dexamethasone used to treat the devastating inherited form of anemia known as Diamond Blackfan anemia.
The Jan. 17 issue of the Journal of the American Medical Association features an important study about sepsis with an accompanying editorial by a University of Nebraska Medical Center expert.
A new Cleveland Clinic study has uncovered a genetic anomaly associated with poor response to a common asthma treatment.
According to new research findings presented this week at the 2019 ACR/ARP Annual Meeting, use of gadolinium-enhanced magnetic resonance imaging (MRI) in shoulders of patients with polymyalgia rheumatica may contribute to more accurate diagnosis and prediction of recurrence.
For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.
Loss of bone density is common as women age, particularly around menopause when women lose more bone than they make. When bone density becomes so low that fracture is likely, the condition is called osteoporosis.
Ewing sarcoma is a bone cancer that appears mainly in teenagers. Due to a single defective gene, once it spreads to distant organs it is hard to treat. Researchers at the Weizmann Institute of Science have discovered molecular interactions underlying Ewing sarcomas and proposed a potential treatment, which has shown promise in a study in mice.
An international, multicenter phase II clinical trial is evaluating the efficacy and safety of mavrilimumab co-administered with a 26-week corticosteroid taper in patients with giant cell arteritis.
Although there is little evidence that opioids effectively reduce pain from rheumatic diseases, a new study finds nearly one in three patients with lupus uses prescription opioids, often lasting longer than a year.
Want to help your child deal with asthma better? A new Northwestern University study says one way is to build a sturdy sense of family bonding, especially in dangerous neighborhoods.
The results from three clinical trials have shown that a new drug can successfully delay the progression of Duchenne muscular dystrophy.
Oral steroid use in patients with the inflammatory diseases polymyalgia rheumatica and/or giant cell arteritis significantly increased the risk of infection, and the risk increased with higher doses, found a study in CMAJ.
The results of a randomized controlled trial presented today at the Annual European Congress of Rheumatology demonstrate high levels of treatment success in approximately two thirds of patients despite tapered glucocorticoid discontinuation, while a small loss of disease control was observed at the total study population level.
Maternal stress during or after pregnancy has been repeatedly associated with subsequent psychiatric problems and non-coding 'epigenetic' DNA changes during childhood.
Today, the American College of Rheumatology, in partnership with the Arthritis Foundation, released two guidelines on juvenile idiopathic arthritis.
Identifying a protein that plays a key role in cancer cell growth is a first step toward the development of a targeted cancer therapy. It is especially promising when this protein is dispensable for the growth of normal cells.
Two proteins that bind to stress hormones work together to maintain a healthy heart in mice, according to scientists at the National Institutes of Health and their collaborators.
Scientists at the University of Cambridge have suggested that subtle changes to the drugs administered to mothers threatened with preterm birth or to premature babies could further improve clinical treatment and help increase their safety.
It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones.
Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout the body, how these adverse effects are caused and by which organ are not well understood.