Glucocorticoid News and Research

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Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).

Early life stress may underlie a pathophysiological exacerbation of postpartum depression

In a new study, a Johns Hopkins Medicine-led research team reports that social stress during adolescence in female mice later results in prolonged elevation of the hormone cortisol after they give birth.

16 Apr 2024

Study unlocks how cortisone activates the body’s natural “brakes” on inflammation

Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions.

10 Apr 2024

Study sheds light on the significance of glucocorticoid receptor in drug-resistant prostate cancer

New research from the University of Eastern Finland sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer, showing that the development of drug resistance could be prevented by limiting the activity of coregulator proteins.

10 Apr 2024

Novel insights into pathologies of diabetic cardiomyopathy, hippocampal neurotoxicity, and Alzheimer’s

DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited.

26 Feb 2024

Increased risk of autoimmune disease after Cushing's disease remission

A study of more than 250 persons undergoing surgical therapy for Cushing's disease (CD) or nonfunctioning pituitary adenomas (NFPAs) found that patients who achieved remission of CD were more likely than those with surgically treated NFPAs to develop new-onset autoimmune disease within 3 years after remission.

19 Feb 2024

New study sheds light on sex differences in allergic airway inflammation

Researchers explored how sex hormones and chromosomes influence allergic inflammation and gene expression in four-core genotype (FCG) mice exposed to house dust mites (HDMs).

7 Feb 2024

Small-molecule A485 mobilizes white blood cells on demand

New study reveals a small molecule that can selectively mobilize white blood cells, offering potential treatments for diseases with abnormal leukocyte counts.

3 Feb 2024

Unbiased assessment of vamorolone for treating Duchenne muscular dystrophy

The drug vamorolone (Agamree) has been hailed as a promising new drug to treat Duchenne muscular dystrophy (DMD).

25 Jan 2024

Social isolation poses greater mortality risk than loneliness in obese individuals, study finds

A study in "JAMA Network Open" reveals that social isolation, more than loneliness, is strongly associated with increased mortality risk in obese individuals compared to those with normal weight.

24 Jan 2024

OSU study pinpoints early muscle loss mechanism in acute spinal cord injury

Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit.

20 Dec 2023

Science tackles mental health: New tools against anxiety and depression in a stressed world

This review in the Proceedings of the National Academy of Sciences discusses the role of scientific tools in combating mental health disorders like anxiety, MDD, and PTSD, emphasizing the need for a deep scientific understanding and diverse treatment approaches in the face of a global surge in psychological stress. The study explores stress biology, treatment strategies, and the importance of personalized scientific approaches to effectively address the mental health crisis.

29 Nov 2023

Decoding anxiety: Study reveals brain's role in behavioral inhibition risks

Researchers in the U.S. used non-human primate models to explore the molecular mechanisms and neural systems behind behavioral inhibition, a key risk factor for anxiety disorders. The study identified molecular systems in the posterior orbitofrontal cortex linked to variations in anxious temperament, offering potential targets for treating anxiety disorders.

28 Nov 2023

Study shows why only a subset of individuals exposed to trauma develop PTSD

A study by researchers at EPFL shows why only a subset of individuals exposed to trauma develop posttraumatic stress disorder (PTSD).

7 Nov 2023

New drug gets FDA approval for the treatment of common genetic disease in young boys

A new drug developed by professors from the School of Pharmacy and Pharmaceutical Sciences at Binghamton University has received Food and Drug Administration (FDA) approval for the treatment of patients with Duchenne muscular dystrophy (DMD), a common genetic disease that mostly affects young boys.

31 Oct 2023

Scientists achieve breakthrough in treating 'neglected' polymyalgia rheumatica

Scientists have found success in treating a 'neglected' inflammatory condition, polymyalgia rheumatica, with a drug that could provide an alternative to steroids for patients.

25 Oct 2023

How the gut microbiome contributes to schizophrenia

Researchers explore potential relationships between schizophrenia, the gut microbiome, the gut-brain axis, and short-chain fatty acids.

19 Oct 2023

Gestational dexamethasone exposure impairs learning and memory function across generations

This new article publication from Acta Pharmaceutica Sinica B, discusses how gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects.

15 Oct 2023

Is night shift work rewiring our appetite and driving weight gain?

Bristol University scientists reveal that night shift work disrupts the body's circadian rhythm, altering appetite-regulating hormones and leading to weight gain. The study, providing insights into metabolic health, may aid in developing treatments for eating disorders and obesity.

10 Oct 2023

Study provides evidence for combination therapy as first-line treatment for relapsed ITP

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, conducted a multicenter comprehensive retrospective analysis to assess the effectiveness and safety of primary single-agent and combination therapies in treating adult patients with relapsed immune thrombocytopenia (ITP).

9 Oct 2023

Inhaled fluticasone furoate falls flat in speeding up COVID-19 recovery, says ACTIV-6 trial

The ACTIV-6 trial investigated the effectiveness of inhaled fluticasone furoate on mild-to-moderate COVID-19 cases and found it did not accelerate recovery or prevent clinical progression compared to a placebo. Interestingly, vaccinated participants showed slightly faster recovery when treated with the drug, while unvaccinated participants did not.

21 Sep 2023