Gluconeogenesis News and Research

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Gluconeogenesis (abbreviated GNG) is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids.

Study may open up new ways of approaching metabolic diseases

A study led by the University of Barcelona and the Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM) reveals how a new mechanism could improve the efficiency of currently available treatments for diabetes.

12 Feb 2024

Study reveals key mechanism behind obesity-related metabolic dysfunction

Researchers found that feeding a high-fat diet (HFD) causes mitochondrial dysfunction and fragmentation in white adipocytes in mice.

31 Jan 2024

D-alanine linked to gluconeogenesis in the kidney and circadian clock

Only recently was it discovered that amino acids, the building blocks of proteins, exist in two different forms: L- and D-forms.

21 Dec 2023

Sympathetic nervous system and immune interplay: Key to metabolic regulation

A review in Advanced Science explores the interaction between the immune system and the sympathetic nervous system in regulating vital metabolic organs like the pancreas, liver, and adipose tissues. This comprehensive analysis provides insights into the neuroimmune relationships affecting metabolism, offering potential new therapeutic strategies for metabolic diseases.

5 Dec 2023

The future of functional foods: Leveraging Dendrobium officinale for optimal gut health and disease prevention

The structure, extraction, health benefits, and mechanisms of Dendrobium officinale polysaccharides (DOPs).

27 Nov 2023

Saliva analysis breakthrough: Detecting cognitive decline stages in Parkinson’s patients

Researchers used integrative metaproteogenomic analysis to show that changes in salivary microbiota and biomolecules can indicate cognitive impairment stages in Parkinson’s disease patients, offering a potential diagnostic tool.

23 Nov 2023

Citrus compounds show zesty promise in type 2 diabetes management

Citrus compounds show promise in type 2 diabetes management, reducing blood glucose and mitigating metabolic complications without a clear threshold in humans for bioflavonoid efficacy.

2 Nov 2023

How is TikTok's #Ozempic trend impacting diabetes patients?

A recent study analyzed TikTok videos with the hashtag "Ozempic," highlighting the platform's influence on promoting the weight loss drug. The surge in popularity resulted in medication shortages for diabetes patients, emphasizing the need for careful monitoring and collaboration among health professionals and social media platforms.

5 Oct 2023

Theabrownin from dark tea may have the potential to treat insulin resistance

The effects of theabrownin (TB) from dark tea treatment on insulin resistance (IR).

8 Sep 2023

Eating for health: how dietary interventions impact pre-diabetic oral and gut microbiome, metabolites and cytokines

Researchers evaluated the impact of two diets on the intestinal and oral microbiota, cytokines, and metabolites of 200 pre-diabetic individuals.

7 Sep 2023

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Researchers examined current evidence on the reasons and implications of pancreatic beta-cell failure.

3 Aug 2023

Study provides new insights into how SARS-CoV-2 affects glucose metabolism

Research conducted at the University of São Paulo (USP) in Brazil shows that SARS-CoV-2, the virus that causes COVID-19, can infect liver cells (hepatocytes), stimulating glucose production and leading to a condition similar to diabetes (hyperglycemia) in hospitalized patients, even if their blood sugar level was normal before they were admitted to hospital.

19 Jul 2023

One-day keto diet boosts energy expenditure, exogenous ketones have little effect

Research aims to compare the effects of a one-day isocaloric ketogenic diet, fasting, and supplementation with ketone salts on energy expenditure and appetite perception. The study found that a 24-hour ketogenic diet may contribute to maintaining a neutral energy balance by increasing energy expenditure.

29 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Researchers find that SARS-CoV-2 directly infects hepatocytes that cause hyperglycemia

Researchers investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused hyperglycemia.

18 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

Researchers discover a key player in preventing 'insulin shock'

Just over a century has passed since the discovery of insulin, a time period during which the therapeutic powers of the hormone have broadened and refined. Insulin is an essential treatment for type 1 diabetes and often for type 2 diabetes, as well.

24 Apr 2023

Proper nutrition could boost recovery from traumatic brain injury

In the first few days after a traumatic brain injury (TBI), food is often an afterthought as clinicians focus on minimizing the damage to the brain.

21 Apr 2023

24 hour ketogenic diet increases energy expenditure, ketone supplements show little effect

In a recent study published in the journal Clinical Nutrition ESPEN, researchers compared the effects of fasting, ketone salt supplementation, and a one-day isocaloric ketogenic diet on the appetite perception and energy expenditure of healthy adults.

12 Apr 2023

Do seasonal changes in food types lead to changes in the composition and structure of gut microbiota?

Researchers assessed the impact of diet or macronutrient consumption on the function and structure of gut microbiota.

6 Mar 2023