Glycan News and Research

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Novel gene-editing strategy harnesses an unusual protective ability to eliminate HIV-1 infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

19 May 2023

SARS-CoV-2 variants show altered glycan processing

Researchers examine spike-protein trimers from SARS-CoV-2 variants to compare the N (asparagine)-glycan landscape.

15 May 2023

Study findings could be harnessed to engineer new botulinum neurotoxin E variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

27 Apr 2023

Researchers identify regions of the viral envelope of simian foamy viruses targeted by neutralizing antibodies

A recent study characterized epitopes recognized by neutralizing antibodies from individuals infected with simian foamy virus.

26 Apr 2023

Revolutionizing Glycobiology: A Mass Spectrometrist's Perspective

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to Professor Albert Heck and gained a mass spectrometrist's perspective on the field of glycobiology.

From Pittcon 24 Apr 2023

Ecological and evolutionary implications of the sharing of metabolites between different microbes in the gut microbiome

The researchers provide important insights into the cross-feeding mechanisms of nutrients in the gut microbiome and their impacts on host health.

18 Apr 2023

Blood levels of glycans can predict the risk of Alzheimer's disease

Early diagnosis and treatment of Alzheimer's disease requires reliable and cost-effective screening methods.

12 Apr 2023

Structure and function of the first FDA-approved treatment for Ebola virus discovered

Scientists at La Jolla Institute for Immunology (LJI) have uncovered the structure and function of the first FDA-approved treatment for Zaire ebolavirus (Ebola virus).

30 Jan 2023

New research draws attention to the effects of deep meditation on gut health

Researchers investigated the effects of long-term traditional Tibetan Buddhist meditation on the gut microbiome's structural characteristics. Additionally, they screened microbes in the gut microbiota for insights into their biochemical indices and functionality.

19 Jan 2023

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Researchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field.

18 Jan 2023

Scientists identify molecules in mucus that can block cholera infection

MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state.

13 Dec 2022

Antibodies against gentamicin associated with increased risk of type 1 diabetes in children

Antibodies produced against the commonly used antibiotic, gentamicin, appear to increase the risk of type 1 diabetes in children already genetically at risk, scientists say.

8 Dec 2022

Glycan signatures in rheumatic diseases and their associated functional implications

A new paper examines the understanding of glycosylation in an array of rheumatic diseases and indicates the potential for therapeutic interventions using the same mechanism.

28 Nov 2022

Potent hypervalent nanoparticles against HIV, Lassa and SARS-CoV-2 variants

In a recent study published in the journal Advanced Science, researchers developed molecularly imprinted nanoparticles (nanoMIPs) with broad-spectrum activity against lethal viruses.

21 Nov 2022

Study provides a guide to neutralizing Lassa virus using a trio of rare antibodies

A new study from scientists at La Jolla Institute for Immunology (LJI) gives researchers a guide to neutralizing Lassa virus using a trio of rare antibodies isolated from survivors of Lassa virus infection.

26 Oct 2022

Scientists map structure of the hepatitis C virus E1E2 glycoprotein complex

A team led by scientists at Scripps Research and the University of Amsterdam has achieved an important goal in virology: mapping, at high resolution, critical proteins that stud the surface of the Hepatitis C virus (HCV) and enable it to enter host cells.

20 Oct 2022

Glycan News and Research

Novel gene-editing strategy harnesses an unusual protective ability to eliminate HIV-1 infection

SARS-CoV-2 variants show altered glycan processing

Study findings could be harnessed to engineer new botulinum neurotoxin E variants

Researchers identify regions of the viral envelope of simian foamy viruses targeted by neutralizing antibodies

Revolutionizing Glycobiology: A Mass Spectrometrist's Perspective

Ecological and evolutionary implications of the sharing of metabolites between different microbes in the gut microbiome

Blood levels of glycans can predict the risk of Alzheimer's disease

Structure and function of the first FDA-approved treatment for Ebola virus discovered

New research draws attention to the effects of deep meditation on gut health

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Scientists identify molecules in mucus that can block cholera infection

Antibodies against gentamicin associated with increased risk of type 1 diabetes in children

Glycan signatures in rheumatic diseases and their associated functional implications

Potent hypervalent nanoparticles against HIV, Lassa and SARS-CoV-2 variants

Study provides a guide to neutralizing Lassa virus using a trio of rare antibodies

Scientists map structure of the hepatitis C virus E1E2 glycoprotein complex

Antibody escape mutations of SARS-CoV-2 BA.2.75

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

Specific N-glycans regulate the development and functional maturation of SARS-CoV-2 spike protein

Synthetic mucin gels against HIV-1 and HSV-2 transmission

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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