Glycoprotein News and Research

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Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

A new study explains how SARS-CoV-2 adapts its immunogenicity to the immune response of the host.

20 Feb 2022

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Researchers investigated the connecting link between viral genetic variability and clinical heterogeneity of COVID-19 by analyzing the effect of several missense mutations on the ACE2 receptor coding sequence.

18 Feb 2022

Advanced imaging reveals the loss of brain synapses in patients with mild symptoms of Alzheimer's

Advanced imaging technology developed by Yale researchers has helped them confirm that the destruction of brain synapses underlies the cognitive deficits experienced by patients with Alzheimer's disease, according to a study published Feb. 17 in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

17 Feb 2022

Ensitrelvir, a novel SARS-CoV-2 antiviral

S-217622 reduces the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

17 Feb 2022

ChAdOx1 vaccine found to protect Syrian hamsters against SARS-CoV-2 variants

Researchers recently evaluated the efficacy of the Oxford ChAdOx1 (AZD 1222/ AZD2816) vaccine against the Omicron, Delta, and Beta variants of SARS-CoV-2 in Syrian hamsters.

17 Feb 2022

Features of platelet-immune crosstalk in healthy recipients of two doses of mRNA-based SARS-CoV-2 vaccine BNT162b2

Researchers investigated the role of platelets in the adverse immune response against a COVID-19 vaccine.

16 Feb 2022

Prediction of SARS-CoV-2 epitope candidates for future vaccines

Researchers identify and investigate the presence and evolution of the SARS-CoV-2 N and S glycoprotein proteins.

15 Feb 2022

Neutralizing antibody levels to different SARS-CoV-2 epitopes fluctuate over time

Researchers study antibodies against various SARS-CoV-2 epitopes that may be responsible for neutralizing activities in recovered COVID-19 patients.

15 Feb 2022

Dynamics and longevity of antibody response from COVID-19 convalescents across the clinical spectrum

Researchers investigated the dynamics and longevity of neutralizing antibody response up to 480 days after the onset of infection in convalescent COVID-19 patients.

9 Feb 2022

Assessing an intranasal lentiviral booster against COVID-19 variants

A new study explores the possibility of vaccination via nasal route utilizing a lentiviral vaccination vector (LV) to be administered as a booster dose against COVID-19.

2 Feb 2022

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Researchers from China summarized the representative structures of SARS-CoV-2 proteins and discussed the development of novel therapeutic agents for targeting these proteins to treat and prevent COVID-19.

2 Feb 2022

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.

1 Feb 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

A synthesis of evidence sheds light on major immune components and mechanisms involved in COVID-19

New research highlights principal host factors that may explain the immune responses to SARS-CoV-2 and its variants in the context of infection susceptibility, disease severity, and previous immunity.

28 Jan 2022

E406W mutation on SARS-CoV-2 RBD escapes monoclonal antibody cocktail-mediated neutralization

Researchers look to better understand the molecular basis of E406W-mediated escape from the REGEN-COV cocktail and cilgavimab.

28 Jan 2022

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

In a new study, a team of researchers developed a vaccine candidate with the SARS-CoV-2 spike (S) glycoprotein coated onto lipid vesicles which resembles virus-like particles.

26 Jan 2022

The Role of Glycans in the Cell and Glycans Imaging Method

In this interview, News-Medical talks to a pioneer of glycan imaging, Richard Drake about glycans, their role in maintaining cellular homeostasis, glycopeptide analysis, and method development for glycan imaging.

From Bruker Life Sciences Mass Spectrometry 26 Jan 2022

Effects of the Omicron spike amino acid changes in the interaction with human ACE2 receptor or human antibodies

A recent study analyzed the effects of the interaction between SARS-CoV-2 Omicron spike amino acid and the human ACE2 receptor or with human antibodies.

26 Jan 2022

COVID-19 vaccine does not lead to infertility in either men or women

In a recent prospective cohort study accepted to the American Journal of Epidemiology, researchers observed links between female and male coronavirus disease 2019 (COVID-19) vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and fecundability or the per-cycle likelihood of conception in North American couples seeking to conceive.

26 Jan 2022

In Portugal risk of hospitalization from Omicron is 75% lower than Delta

Researchers from Portugal reported a 75% risk reduction in hospitalizations for individuals infected with Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to the Delta variant and a shorter length of stay and lower mortality if hospitalization does occur. Their paper is currently available on the medRxiv* preprint server while undergoing peer review.

24 Jan 2022

Glycoprotein News and Research

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Advanced imaging reveals the loss of brain synapses in patients with mild symptoms of Alzheimer's

Ensitrelvir, a novel SARS-CoV-2 antiviral

ChAdOx1 vaccine found to protect Syrian hamsters against SARS-CoV-2 variants

Features of platelet-immune crosstalk in healthy recipients of two doses of mRNA-based SARS-CoV-2 vaccine BNT162b2

Prediction of SARS-CoV-2 epitope candidates for future vaccines

Neutralizing antibody levels to different SARS-CoV-2 epitopes fluctuate over time

Dynamics and longevity of antibody response from COVID-19 convalescents across the clinical spectrum

Assessing an intranasal lentiviral booster against COVID-19 variants

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A synthesis of evidence sheds light on major immune components and mechanisms involved in COVID-19

E406W mutation on SARS-CoV-2 RBD escapes monoclonal antibody cocktail-mediated neutralization

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

The Role of Glycans in the Cell and Glycans Imaging Method

Effects of the Omicron spike amino acid changes in the interaction with human ACE2 receptor or human antibodies

COVID-19 vaccine does not lead to infertility in either men or women

In Portugal risk of hospitalization from Omicron is 75% lower than Delta

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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