Growth Factor News and Research

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Protein loss plays role in acute T-cell leukemia

The loss of a key protein (Smad3) in a pathway that helps prevent tumors from forming is specific to one form of childhood leukemia, but not to other pediatric and adult forms of leukemia, according to a new study published in the August 5, 2004, New England Journal of Medicine.

5 Aug 2004

Researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse model for Parkinson's disease

The finding suggests that a similar therapy might eventually be able to slow the devastating course of Parkinson's disease in humans.

29 Jul 2004

Proof of principle that it is possible to deliver new genes body-wide to all the muscles of an adult animal

MDA-supported researchers at the University of Washington-Seattle have delivered the gene for the dystrophin protein to all voluntary muscles with a single intravenous injection in mice with Duchenne muscular dystrophy (DMD).

29 Jul 2004

Further evidence about how estrogen helps activate breast cancer

A UC Irvine researcher has found a novel tumor- suppressor function for a gene that, when mutated, often triggers breast cancer in women.

29 Jul 2004

Finding helps explain how nerves connect to their targets and stop growing once there

Johns Hopkins researchers report that once a growing nerve "tastes" a certain protein, it loses its "appetite" for other proteins and follows the tasty crumbs to reach its final destination.

26 Jul 2004

Erbitux (cetuximab) combined with irinotecan offers another option for patients who have colorectal cancer

Erbitux (cetuximab), offers another option for patients who have colorectal cancer that resists standard chemotherapy treatment, according to an article written by two Mayo Clinic cancer researchers published in the current edition of the New England Journal of Medicine.

21 Jul 2004

CancerVax may increase the survival of patients with advanced stage non-small-cell lung cancer

CancerVax Corporation has announced that its wholly owned subsidiaries, Tarcanta, Inc., and Tarcanta, Ltd. (Ireland), have obtained the exclusive rights to complete the clinical development of three specific active immunotherapeutic (SAI) product candidates that target the epidermal growth factor receptor (EGFR) signaling pathway for the treatment of cancer.

19 Jul 2004

Using a combination of therapies and cell grafts could help treat patients with chronic spinal cord injuries

Using a combination of therapies and cell grafts, a team of University of California, San Diego (UCSD) School of Medicine researchers has promoted significant regeneration of nerve cells in rats with spinal cord injury.

15 Jul 2004

Research provides new insight into the carefully controlled architectural changes that underlie organ development

A new research study demonstrates that a single chemical growth factor orchestrates a complex developmental process by sequentially activating distinct subsets of molecular signals.

13 Jul 2004

Increasing levels of growth hormone may be an effective treatment for HIV lipodystrophy

Increasing the body's production of growth hormone may be an effective treatment for HIV lipodystrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection.

11 Jul 2004

New compound, ZK-CDK combines the inhibition of tumour cell growth as well as inhibition of tumour angiogenesis in one single molecule

Treatment with a new dual cell cycle and angiogenesis pathway inhibitor blocks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models

7 Jul 2004

Research describes how nerve growth factor stimulates a sequence of proteins that promote nerve growth

Scientists at the University of North Carolina at Chapel Hill have discovered key steps involved in regulating nerve growth and regeneration that may have implications for spinal cord research.

1 Jul 2004

Chemicals that inhibit the development of new blood vessels could prove to be a new way of treating endometriosis

Chemicals that inhibit the development of new blood vessels could prove to be a new way of treating endometriosis, according to research from The Netherlands and the USA presented today (Monday 28 June) at the 20th annual meeting of the European Society of Human Reproduction and Embryology.

28 Jun 2004

European Commission has approved the use of Herceptin® (trastuzumab) in combination with Taxotere®

The approval is based on study results which showed that for women with HER2-positive breast cancer, the combination of Herceptin and Taxotere significantly improved median life expectancy by more than one-third (31 months with Herceptin plus Taxotere vs. 22 months for Taxotere alone).

23 Jun 2004

Potential new strategy for blocking tumor growth

Targeting a master molecule that helps cancer cells survive when blood oxygen levels are low may offer a potentially powerful strategy for blocking tumor growth, say researchers at The University of Texas M. D. Anderson Cancer Center.

16 Jun 2004

Cancer drug gefitinib (Iressa) may be able to restore tamoxifen's anticancer activity

A new study has found a possible mechanism for tamoxifen resistance in breast cancer and provides evidence that another cancer drug--gefitinib (Iressa)--may be able to restore tamoxifen's anticancer activity.

15 Jun 2004

Body fat not always bad

With the threat of an obesity crisis looming, a study led by UCL researchers reveals today that fat tissue isn’t always the enemy. Reporting in the journal Science they show that a molecular signalling pathway in fat tissue is an important mediator in extending lifespan.

11 Jun 2004

Multi-targeted anticancer drug shows promise as treatment for metastatic renal cell cancer

A new multi-targeted anticancer drug called SU11248 has shown very promising results in the treatment for metastatic renal cell cancer, one of the most chemotherapy resistant of all cancers.

6 Jun 2004

Vitamin C can increase the severity of spontaneous knee osteoarthritis

High doses of vitamin C increase the severity of spontaneous knee osteoarthritis in an animal model of the disease, according to a new study by Duke University Medical Center researchers.

5 Jun 2004

Drug Tarceva improves survival chance for patients with advanced lung cancer

Roche OSI Pharmaceuticals and Genentech today announced that their investigational drug Tarceva(TM) (erlotinib) achieved a significant 42.5% improvement in median survival compared to placebo in patients with advanced non-small cell lung cancer (NSCLC).

5 Jun 2004

Growth Factor News and Research

Protein loss plays role in acute T-cell leukemia

Researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse model for Parkinson's disease

Proof of principle that it is possible to deliver new genes body-wide to all the muscles of an adult animal

Further evidence about how estrogen helps activate breast cancer

Finding helps explain how nerves connect to their targets and stop growing once there

Erbitux (cetuximab) combined with irinotecan offers another option for patients who have colorectal cancer

CancerVax may increase the survival of patients with advanced stage non-small-cell lung cancer

Using a combination of therapies and cell grafts could help treat patients with chronic spinal cord injuries

Research provides new insight into the carefully controlled architectural changes that underlie organ development

Increasing levels of growth hormone may be an effective treatment for HIV lipodystrophy

New compound, ZK-CDK combines the inhibition of tumour cell growth as well as inhibition of tumour angiogenesis in one single molecule

Research describes how nerve growth factor stimulates a sequence of proteins that promote nerve growth

Chemicals that inhibit the development of new blood vessels could prove to be a new way of treating endometriosis

European Commission has approved the use of Herceptin® (trastuzumab) in combination with Taxotere®

Potential new strategy for blocking tumor growth

Cancer drug gefitinib (Iressa) may be able to restore tamoxifen's anticancer activity

Body fat not always bad

Multi-targeted anticancer drug shows promise as treatment for metastatic renal cell cancer

Vitamin C can increase the severity of spontaneous knee osteoarthritis

Drug Tarceva improves survival chance for patients with advanced lung cancer

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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