Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

Cachexia reduces function and changes muscle structure of heart in mice with colon cancer

The wasting disease associated with some cancers that is typically seen affecting skeletal muscles can also cause significant damage to the heart, new research in mice suggests.

9 Sep 2010

Arcapita enters equity investment, option to purchase agreement with St. Jude Medical

Arcapita, a global investment company, announced today that Atlanta-based CardioMEMS, an Arcapita Ventures portfolio company, has entered into an equity investment and option to purchase agreement with St. Jude Medical, a global medical device company.

9 Sep 2010

St. Jude Medical to invest $60M in CardioMEMS

St. Jude Medical, Inc., a global medical device company, and privately-held CardioMEMS today announced that they have reached an agreement under which St. Jude Medical will make a $60 million equity investment in CardioMEMS, a medical device company that has developed a wireless sensing and communication technology to assess cardiac performance.

7 Sep 2010

Researchers to study protein fragments released into bloodstream after heart attack

A blood test to diagnose which heart attack survivors will suffer heart failure is the goal of a new five-year, $11.6 million contract to the UT Health Science Center San Antonio from the National Heart, Lung, and Blood Institute (NHLBI).

4 Sep 2010

FDA approves IDE study to evaluate HeartWare Ventricular Assist System

HeartWare International, Inc., a leading innovator of less invasive, miniaturized circulatory support technologies that are revolutionizing the treatment of advanced heart failure, today announced that the U.S. Food and Drug Administration (FDA) has approved an IDE (Investigational Device Exemption) Supplement that allows HeartWare to enroll a second allotment of 54 patients in its "ADVANCE" bridge-to-transplant clinical trial under a Continued Access Protocol (CAP).

4 Sep 2010

Cardiogenesis Corporation releases comment on STAR-heart study

Cardiogenesis Corporation, released comments today regarding the STAR-heart study.The STAR-heart study, which was presented at the European Society of Cardiology 2010 Congress in August 2010, reported that the intracoronary injection of autologous stem cells derived from bone marrow is associated with improved hemodynamics and long term survival in the treatment of chronic heart failure.

3 Sep 2010

European Commission approves MSD's MAA for SYCREST in manic episodes associated with bipolar I disorder

MSD announced today that the European Commission has approved the Marketing Authorization Application (MAA) for SYCREST® (asenapine) sublingual tablets for the treatment of moderate to severe manic episodes associated with bipolar I disorder in adults. Today's decision was based on recommendations from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP). The Commission Decision applies to all 27 European Member States.

3 Sep 2010

BRINAVESS IV granted marketing approval in EU for conversion of recent onset AF to sinus rhythm

MSD and Cardiome Pharma Corp. today announced that the intravenous (IV) formulation of BRINAVESS™ (vernakalant) has been granted marketing approval in the European Union (EU), Iceland and Norway for the conversion of recent onset atrial fibrillation (AF) to sinus rhythm in adults.

2 Sep 2010

ESC releases new Clinical Practice Guidelines for management of Grown-up Congenital Heart Disease

The European Society of Cardiology (ESC) today announces the release of new Clinical Practice Guidelines covering the management of Grown-up Congenital Heart Disease (GUCH). More than two million adults in Europe are assumed to be affected by the condition, and the numbers are growing as a consequence of sharply increased survival rates due to advances in paediatric cardiology and heart surgery.

2 Sep 2010

Research finds link between chronic heart failure, iron deficiency

Iron plays a key role in human homeostasis. It is essential for growth and survival, and is a vital ingredient in numerous processes including erythropoiesis, oxygen transport and storage, oxidative metabolism in the skeletal and heart muscle, synthesis and degradation of lipids, carbohydrates, DNA and RNA. Important though it is, iron metabolism must be precisely controlled because iron is insoluble and excess levels can be toxic.

2 Sep 2010

ESC updates Clinical Practice Guidelines on devices for heart failure treatment

The European Society of Cardiology (ESC) today announces a focused update of its Clinical Practice Guidelines covering Device Therapy in Heart Failure. This is the first time that current ESC guidelines have been updated, reflecting the pace of research in this field and the importance of recently published evidence.

2 Sep 2010

High vitamin D level improves survival rate in heart failure patients: Study

Survival rates in heart failure patients with reduced levels of vitamin D are lower than in patients with normal levels. This is the finding of a major study carried out at University Medical Center, Groningen, Netherlands. Results also suggest that low levels of vitamin D are associated with activation of the Renin Angiotensin System (RAS - a pivotal regulatory system in heart failure) and an altered cytokine profile.

2 Sep 2010

High levels of OPG hormone associated with adverse outcome after myocardial infarction

Patients suffering with heart failure are more likely to die if they have high levels of a bone hormone called osteoprotegerin (OPG).

2 Sep 2010

Incidence of acute myocardial infarction increases among young Italian women: Study

The incidence of acute myocardial infarction in Italy sharply increased, particularly among young women, between the years 2001 and 2005, according to a comprehensive study funded by the Human Health Foundation, a nonprofit Italian charity for biomedical research and health education in Spoleto, Italy. The results were published in Aging Clinical Experimental Research.

31 Aug 2010

ESC issues revised practice guidelines for management of AF

The European Society of Cardiology today issued revised practice guidelines for the management of atrial fibrillation, including guidance on the role of a novel oral treatment, dabigatran etexilate, for the prevention of stroke and systemic embolism in patients with atrial fibrillation.

31 Aug 2010

DANPACE trial shows dual chamber pacing decreases atrial fibrillation in sick sinus syndrome

DANPACE, a Danish multicentre randomised trial comparing single lead atrial and dual chamber pacing in patients with sick sinus syndrome, concludes that dual chamber pacing, which was associated with lower rates of atrial fibrillation and re-operation, "should be the preferred pacing mode".

31 Aug 2010

ANTIPAF trial reveals ARBs do not reduce number of AF episodes in paroxysmal AF patients

Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting about 7 million people in Europe. It is a progressive chronic disease in which episodes become more frequent and long-lasting over time. Conventional anti-arrhythmic therapy aims at halting progression and reducing symptoms, but the use of most anti-arrhythmic drugs is compromised by severe side effects, such as pro-arrhythmia or extra-cardiac organ toxicity.

31 Aug 2010

Bioheart's MyoCell adult stem cell therapy shows effective for heart failure patients: Study

Bioheart, Inc., The mission of the Cell Therapy Foundation is to improve public health through the support of effective adult stem cell research and education. The Foundation aims to promote basic and applied knowledge, processes and cell therapies.

31 Aug 2010

Study: IV ibuprofen decreases pain, morphine use in pre and post-operative orthopedic surgery patients

Cumberland Pharmaceuticals Inc. today announced the publication of new data supporting the safety and efficacy of Caldolor® (ibuprofen) Injection in pre and post-operative orthopedic surgery patients. The study, which was published in the August edition of the peer-reviewed journal Pain Medicine, concludes that IV ibuprofen significantly decreased pain and morphine use when compared with placebo.

31 Aug 2010

Disruption of structural component in heart muscle cells occurs before decline in heart function

The disruption of a structural component in heart muscle cells, which is associated with heart failure, appears to occur even before heart function starts to decline, according to a new study by researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

31 Aug 2010

Heart Failure News and Research

Further Reading

Cachexia reduces function and changes muscle structure of heart in mice with colon cancer

Arcapita enters equity investment, option to purchase agreement with St. Jude Medical

St. Jude Medical to invest $60M in CardioMEMS

Researchers to study protein fragments released into bloodstream after heart attack

FDA approves IDE study to evaluate HeartWare Ventricular Assist System

Cardiogenesis Corporation releases comment on STAR-heart study

European Commission approves MSD's MAA for SYCREST in manic episodes associated with bipolar I disorder

BRINAVESS IV granted marketing approval in EU for conversion of recent onset AF to sinus rhythm

ESC releases new Clinical Practice Guidelines for management of Grown-up Congenital Heart Disease

Research finds link between chronic heart failure, iron deficiency

ESC updates Clinical Practice Guidelines on devices for heart failure treatment

High vitamin D level improves survival rate in heart failure patients: Study

High levels of OPG hormone associated with adverse outcome after myocardial infarction

Incidence of acute myocardial infarction increases among young Italian women: Study

ESC issues revised practice guidelines for management of AF

DANPACE trial shows dual chamber pacing decreases atrial fibrillation in sick sinus syndrome

ANTIPAF trial reveals ARBs do not reduce number of AF episodes in paroxysmal AF patients

Bioheart's MyoCell adult stem cell therapy shows effective for heart failure patients: Study

Study: IV ibuprofen decreases pain, morphine use in pre and post-operative orthopedic surgery patients

Disruption of structural component in heart muscle cells occurs before decline in heart function

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Expanding research and clinical options for children with cancer

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