High Throughput News and Research

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Medical conference to discuss the current and future use of CT and MRI in autopsy practice

A leading forensic pathologist from the University of Leicester is among the keynote speakers at a unique medical conference in the city examining The Use of CT and MRI in Autopsy Practice.

17 Sep 2009

Findings may lead to drugs that destroy TB in dormant stage of lifecycle

Attempts to eradicate tuberculosis (TB) are stymied by the fact that the disease-causing bacteria have a sophisticated mechanism for surviving dormant in infected cells. Now, a team of scientists led by researchers from Weill Cornell Medical College has identified compounds that inhibit that mechanism -- without damaging human cells.

17 Sep 2009

New book on human genetics helps to unravel complex human diseases

Many human diseases-including Alzheimer's disease, schizophrenia, cancer, and cardiovascular disease-are caused by multiple genetic variants and the interaction of those variants with the environment. Because such diseases lack a clear-cut inheritance pattern, sophisticated technological approaches and statistical analyses are required to determine their underlying cause.

15 Sep 2009

Scientists to get funding from The European Research Council

The European Research Council (ERC) expects to fund some 240 top researchers in its second prestigious ERC Starting Grant competition. This new wave of grantees follows the 299 researchers who received grants in the first Starting Grant competition in 2007.

11 Sep 2009

Roche scientists use their xCELLigence System to analyze nutlin-induced apoptosis

The p53 tumor suppressor, a transcription factor that activates or inhibits hundreds of genes, either directly or indirectly, triggers a variety of cellular effects and plays a central role in the cellular defense against cancer. One of the main approaches for pharmacological intervention is to activate wild-type p53 in cancer cells by blocking MDM2 from binding to p53.

11 Sep 2009

ERC funds DiaDrug project to study the link between insulin resistance and albuminuria

11 Sep 2009

New study reveals that actual sex ratios can sway from the ideal

In a perfect world, for every boy there would of course be a girl, but a new study shows that actual sex ratios can sometimes sway very far from that ideal. In fact, the male-to-female ratio of one tropical butterfly has shifted rapidly over time and space, driven by a parasite that specifically kills males of the species, reveals a report published online on September 10th in Current Biology, a Cell Press publication.

11 Sep 2009

ARUP Laboratories' scientist receives grant to research HIV therapies

ARUP Laboratories, a national clinical and anatomic pathology reference laboratory and a leader in innovative laboratory research and development, announced that ARUP's Tanya Sandrock, PhD, Research & Development scientist, received a prestigious National Institutes of Health (NIH) grant to research additional HIV therapies.

9 Sep 2009

BioLeap and GSK collaborate to discover novel medicines

BioLeap and GSK have entered into an agreement whereby BioLeap will design novel lead compounds for "difficult" drug targets. The targets (not disclosed) are ones for which conventional approaches, like high throughput screening, have failed to yield a viable chemical starting point. Typically these are in areas of high unmet medical need.

9 Sep 2009

Phenotype microarrays compare growth characteristics of pathogenic and non-pathogenic E. coli

Dr Karin Heurlier and colleagues at the Universities of Nottingham and Birmingham in conjunction with Biolog Inc of California USA, used powerful high throughput analytical tools (phenotype microarrays) that enabled them to compare about 2000 growth characteristics of several pathogenic (disease-causing) E. coli with a non-pathogenic laboratory E. coli strain.

9 Sep 2009

BioTrove partners with FDA to investigate the utility of SNAP system

BioTrove announced a collaboration with the U.S. Food and Drug Administration’s Center for Biologics Evaluation and Research to investigate the utility of the company’s Standardized NanoArray PCR (SNAP) gene expression profiling system for the rapid and specific detection of pathogens in the nation’s blood supply.

8 Sep 2009

Dr Lluis Quintana-Murci from the Institut Pasteur in France honoured with the Debiopharm Life Sciences Award

Debiopharm Group, SA (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, today presented the 'Debiopharm Life Sciences Award' to Dr Lluis Quintana-Murci from the Institut Pasteur in France, for his outstanding innovative research in the emerging field of evolutionary genetics of infection.

4 Sep 2009

Two new antibodies for targeting HIV virus discovered

Researchers at and associated with the International AIDS Vaccine Initiative (IAVI), at The Scripps Research Institute, and at the biotechnology companies Theraclone Sciences and Monogram Biosciences have discovered two powerful new antibodies to HIV that reveal what may be an Achilles heel on the virus. They published their work in Science this week.

3 Sep 2009

New computer software capable of sifting through hundreds of cancer causing genetic mutations

Johns Hopkins engineers have devised innovative computer software that can sift through hundreds of genetic mutations and highlight the DNA changes that are most likely to promote cancer.

1 Sep 2009

Psychogenics and Astrazeneca sign agreement to identify new compounds for treating Central Nervous System disorders

PsychoGenics Inc. and AstraZeneca have entered into a drug discovery and development agreement to identify compounds that are likely to be useful for the treatment of certain Central Nervous System (CNS) disorders.

31 Aug 2009

Neurogen stockholders to receive $11 million in Ligand Pharmaceuticals common stock as part of acquisition deal

Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) and Neurogen Corporation (NASDAQ:NRGN) announced today they have entered into a definitive merger agreement under which Ligand will acquire Neurogen. Under the transaction, Neurogen stockholders will receive an estimated $11 million in Ligand common stock and will be granted Contingent Value Rights (“CVRs”) under four CVR agreements.

25 Aug 2009

Complete Genomics raises $45 million in private equity financing

Complete Genomics Inc., a third-generation human genome sequencing company, announced that it has raised $45 million in private equity financing and closed its Series D funding round with two new investors — Essex Woodlands Health Ventures and OrbiMed Advisors, LLC.

24 Aug 2009

Southern Research's Birmingham campus to have a Comprehensive Chemical Biology Center

Southern Research Institute today announced that it has been selected as one of 11 organizations to help establish the National Cancer Institute's (NCI) Chemical Biology Consortium (CBC)--a program meant to coordinate and accelerate the discovery and development of new therapeutic agents to treat cancer patients. Southern Research will establish one of NCI's five Comprehensive Chemical Biology Centers at its Birmingham campus.

21 Aug 2009

Fluxion Biosciences receives a $1.8 million NIH grant for developing microfluidic platform

Fluxion Biosciences, a leading developer of microfluidic systems for functional cell analysis, today announced that it has received a $1.8 million NIH grant for the development of a high-throughput screening platform for anti-microbial drug discovery.

From Fluxion Biosciences 20 Aug 2009

New Liquid Water Isotope Analyzer for measuring stable isotopes of liquid water

Los Gatos Research (LGR), the leading innovator of cavity-enhanced laser-based instrumentation for analyses of gases and liquids, today announced the availability of the second-generation Liquid-Water Isotope Analyzer (LWIA).

20 Aug 2009

High Throughput News and Research

Medical conference to discuss the current and future use of CT and MRI in autopsy practice

Findings may lead to drugs that destroy TB in dormant stage of lifecycle

New book on human genetics helps to unravel complex human diseases

Scientists to get funding from The European Research Council

Roche scientists use their xCELLigence System to analyze nutlin-induced apoptosis

ERC funds DiaDrug project to study the link between insulin resistance and albuminuria

New study reveals that actual sex ratios can sway from the ideal

ARUP Laboratories' scientist receives grant to research HIV therapies

BioLeap and GSK collaborate to discover novel medicines

Phenotype microarrays compare growth characteristics of pathogenic and non-pathogenic E. coli

BioTrove partners with FDA to investigate the utility of SNAP system

Dr Lluis Quintana-Murci from the Institut Pasteur in France honoured with the Debiopharm Life Sciences Award

Two new antibodies for targeting HIV virus discovered

New computer software capable of sifting through hundreds of cancer causing genetic mutations

Psychogenics and Astrazeneca sign agreement to identify new compounds for treating Central Nervous System disorders

Neurogen stockholders to receive $11 million in Ligand Pharmaceuticals common stock as part of acquisition deal

Complete Genomics raises $45 million in private equity financing

Southern Research's Birmingham campus to have a Comprehensive Chemical Biology Center

Fluxion Biosciences receives a $1.8 million NIH grant for developing microfluidic platform

New Liquid Water Isotope Analyzer for measuring stable isotopes of liquid water

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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