High Throughput News and Research

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Discovery of new cancer gene

Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes.

29 Mar 2009

DNA-based assembly line for precision nano-cluster construction

Building on the idea of using DNA to link up nanoparticles - particles measuring mere billionths of a meter - scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have designed a molecular assembly line for predictable, high-precision nano-construction.

29 Mar 2009

Scientists find molecular mechanisms linking sugar production and longevity

Johns Hopkins researchers have discovered a new energy-making biochemical twist in determining the lifespan of yeast cells, one so valuable to longevity that it is likely to also functions in humans.

23 Mar 2009

New RNA-Seq technique used to profile anthrax genome

Scientists at the Georgia Institute of Technology have used a new approach, known as RNA-Seq, to profile the gene expression of the bacterium that causes anthrax, Bacillus anthracis.

22 Mar 2009

Examining the infinitesimal - new approach to microscopy

A new approach to microscopy is opening up the wonders of the molecular world, allowing researchers to examine organic molecules and delicate crystals as they grow, atom by atom. Dr Andrew Humhpris, co-founder of the original technology and now Chief Technology Officer of Infinitesima, explains how this University spin-out has turned into a leading-edge company.

17 Mar 2009

Discovery of master switch that might prevent cancer cells from metastasizing

Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs.

16 Mar 2009

Proteomics study shows that genes involved in invertebrate longevity have surprising parallels in humans

Prolexys Pharmaceuticals has announced the publication of the discovery of genes that are likely to have a role in the aging process of humans.

15 Mar 2009

ADMEcell enters into manufacturing and distribution agreement with Advancell

ADMEcell, announced that it has entered into an exclusive agreement with Advancell, Barcelona, Spain, to manufacture and distribute the CacoReady System for the North American market.

15 Mar 2009

Phylonix granted broad U.S. patent for assessing cardiac functions in Zebrafish

Phylonix Pharmaceuticals announced, at the Society of Toxicology Annual Meeting in Baltimore, that the U.S. Patent and Trademark Office has issued the company a broad patent for assessing the toxicity of pharmaceutical test agents on cardiovascular functions in zebrafish.

15 Mar 2009

University at Buffalo to receive $4.9 million in stem cell research funds from New York State

The University at Buffalo will receive $4.9 million in funding to conduct research on stem cells, part of a new investment in stem cell research announced yesterday by New York State Governor David A. Paterson.

11 Mar 2009

Small molecules block cancer gene

Finding molecules that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, said a Baylor College of Medicine researcher in a report that appears in the current online issue of the journal PLoS One (Public Library of Science ONE).

11 Mar 2009

Genetic mutations suggest link between type 1 diabetes and common viral infection

Scientists from Cambridge University have discovered four rare mutations of a gene associated with type 1 diabetes (T1D) that reduce the risk of developing the disease.

5 Mar 2009

Hendra and Nipah viruses shown to be susceptible to chloroquine

Two highly lethal viruses that have emerged in recent outbreaks are susceptible to chloroquine, an established drug used to prevent and treat malaria, according to a new basic science study by researchers at Weill Cornell Medical College in the Journal of Virology.

5 Mar 2009

Compounds that trigger beta cell replication identified

Researchers at the Genomics Institute of the Novartis Research Foundation (GNF) have identified a set of compounds that can trigger the proliferation of insulin-producing cells in the pancreas, using sophisticated high-throughput screening techniques.

25 Feb 2009

Calculating protein and gene connections in a Parkinson's model

Researchers have created an algorithm that meshes existing data to produce a clearer step-by-step flow chart of how cells respond to stimuli.

22 Feb 2009

New device decreases wait times for patients needing immunotherapy

Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have created a device that significantly decreases the time needed to produce genetically manipulated T cells in preclinical tests for leukemia.

16 Feb 2009

New findings raise questions about process used to identify experimental drug

A study by National Institutes of Health (NIH) researchers has revealed surprising new insights into the process used to initially identify an experimental drug now being tested in people with cystic fibrosis and muscular dystrophy.

3 Feb 2009

Studies offer guide as protein interaction mapping comes of age

During the past 20 years, researchers have identified thousands of cell protein interactions, with the ultimate goal of inventorying all that occur within cells of various organisms - a comprehensive catalogue known as the interactome.

6 Jan 2009

What are protective effects of anti-ricin A-chain aptamer?

Ricin, a lectin from the castor bean plant Ricinus communis is considered one of the most potent plant toxins.

30 Dec 2008

Both theories about human cellular aging supported by new research

Aging yeast cells accumulate damage over time, but they do so by following a pattern laid down earlier in their life by diet as well as the genes that control metabolism and the dynamics of cell structures such as mitochondria, the power plants of cells.

16 Dec 2008