High Throughput News and Research

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World Fusion creates sequence analysis service center with bioinformatics infrastructure

Today Japanese informatics management experts, World Fusion, announced the creation of a sequence analysis service center with a bioinformatics infrastructure based on CLC bio's enterprise platform for high-throughtput sequencing data analysis, coupled with World Fusion's own Life Science Knowledge Bank (LSKB) bio knowledge database system.

19 Aug 2010

Chronix Biomedical expands biomarker development capabilities with installation of DNA mass sequencer

Chronix Biomedical today reported that it has significantly expanded and accelerated its biomarker development capabilities with the installation of Germany's first state-of-the-art high-throughput DNA mass sequencer at the University of Göttingen, Chronix's long-time collaborator. Chronix is developing disease-specific biomarkers based on DNA fragments that are released into the bloodstream by damaged and dying (apoptotic) cells.

17 Aug 2010

Scientists find epigenetic landscape map for tissue differentiation

Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation.The details of this collaborative study between Johns Hopkins, Stanford and Harvard appear August 15 in the early online publication of Nature.

17 Aug 2010

CLC bio, PSSC Labs announce new turnkey solution for full-genome assembly and analysis

Today, CLC bio and PSSC Labs announced a new turnkey solution, CLC Genomics Factory, for assembly, read mapping, and subsequent downstream analysis of very large amounts of high-throughput DNA and RNA sequencing data. Built as a high-performance bioinformatics appliance, CLC Genomics Factory comes in three different sizes with varying numbers of compute nodes, capable of processing the data output from up to 10 Illumina HiSeq2000 or 7 Life Technologies SOLiD 4 systems.

13 Aug 2010

Researchers find transposons determine differences in physical traits, disease risks

Building on a tool that they developed in yeast four years ago, researchers at the Johns Hopkins University School of Medicine scanned the human genome and discovered what they believe is the reason people have such a variety of physical traits and disease risks.

12 Aug 2010

Ohio State University procures IonFlux 16 high throughput automated patch clamp instrument

Fluxion Biosciences, Inc. announced today that the Ohio State University Department of Pharmacology has purchased the IonFlux 16, the first high throughput automated patch clamp instrument of its kind geared towards the academic researcher. The IonFlux instrument will enable large scale pharmacology experiments on this group's nAChR targets, which previously were not feasible using a manual patch clamp rig.

From Fluxion Biosciences 11 Aug 2010

Protagen granted Notice of Allowance in Japan for key method patent for identifying and selecting clones

Protagen AG, a specialist for in-vitro diagnostics and GMP-compliant protein analysis, announced today that it received a Notice of Allowance by the Japanese Patent Office stating a favourable decision for the patent application 2000-547262 developed at the Max-Planck Institute for Molecular Genetics in Berlin, Germany. This patent claims broadly a method for identifying and selecting clones relating to the basic UNIclone® technology and is already granted in Europe with the publication number EP1073770 B1.

11 Aug 2010

UCSF researchers discover new technology purifying special types of stem cells

UCSF researchers are reporting the first success in very rapidly purifying one type of embryonic stem cell from a mix of many different types of embryonic stem cells in the culture dish. The technique, which avoids the need to genetically alter the cells to distinguish them, is a key advance, the researchers say, for obtaining the appropriate cells for repairing specific damaged tissues.

7 Aug 2010

WaferGen launches SmartChip System for discovery, validation of biomarkers

WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced it has launched the breakthrough WaferGen SmartChip Real-Time PCR System, the next-generation Real-Time PCR system for discovery and validation of biomarkers, or gene expression patterns, on a single platform. The SmartChip System is designed to provide accurate, highly sensitive and high-throughput gene expression profiling capabilities to researchers, clinicians and pharmaceutical companies.

6 Aug 2010

Sigma-Aldrich, NHLBI and BU collaborate in atherosclerotic cardiovascular disease research

Sigma-Aldrich® today announced it has entered into an agreement with the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, and Boston University (BU) to develop methods to measure several potential biomarkers of atherosclerotic cardiovascular disease (CVD) using plasma samples from the NHLBI's Framingham Heart Study (FHS), one of the most prestigious clinical studies in medicine. Funding for the project is provided by the NHLBI to Sigma-Aldrich under a research subaward agreement with BU.

5 Aug 2010

BCM collaborates with Roche NimbleGen for high throughput exome capture technology

The Baylor College of Medicine Human Genome Sequencing Center has standardized its target enrichment human disease research studies on Roche NimbleGen Sequence Capture Exome technology. The Baylor HGSC will sequence over 5,000 exomes in the next two years to identify genetic variants underlying multiple human diseases and will employ NimbleGen SeqCap EZ Exome and customized NimbleGen exome designs as the exome capture technology of choice. More than 15 different diseases will be investigated by Baylor HGSC, including brain, liver, pancreatic, colon, ovarian and bladder cancers, heart disease, diabetes, autism, and other inherited diseases with the goal of better understanding causative mutations and their impact on these diseases.

4 Aug 2010

Biotage launches Isolera ELSD-1080 evaporative light-scattering detector for flash purification

Biotage, a leading supplier of tools and technology for medicinal and analytical chemistry, announced the launch of the Isolera ELSD-1080 evaporative light-scattering detector for flash purification. With the addition of the ELSD-1080, Biotage now provides a flash purification solution for nearly every compound type including semi-volatile UV transparent as well as UV absorbing compounds.

30 Jul 2010

Thermo Fisher Scientific introduces low evaporation plates for cell culture and high content analysis

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the Thermo Scientific Nunc Edge 96-well Plates for cell-based assays.

From Thermo Fisher Scientific Inc. 29 Jul 2010

Redpoint Bio issued patent that covers high-throughput screening technology

Redpoint Bio Corporation, a company focused on the development of healthier foods and beverages and new approaches to the treatment of diabetes and obesity, today announced the issuance of Patent No. 7,749,730 B2 by the U.S. Patent and Trademark Office entitled "High Throughput Screening Assay for the TRPm5 Ion Channel."

28 Jul 2010

Integral Molecular receives patent for Lipoparticle membrane protein technology

Integral Molecular, Inc. today announced the issuance of a key patent covering its technology for deriving high concentrations of membrane proteins. The patent, issued by the U.S. Patent and Trademark Office, covers the core composition of Integral Molecular's Lipoparticle technology, a novel cell-free format for deriving highly-concentrated membrane proteins for antibody development, drug discovery, and biomedical research.

28 Jul 2010

Affymetrix to develop, commercialize Axiom Chinese myDesign Genotyping Array

Affymetrix, Inc. today announced that it will develop and commercialize the Axiom Chinese myDesign Genotyping Array, the first product that provides maximum power for genome-wide association studies specifically on Chinese populations.

28 Jul 2010

Progenra receives Official Notice of Allowance for screening platform

Progenra, Inc., announced today their receipt of an Official Notice of Allowance, dated June 15, 2010, of U.S. Patent Application No. 11/156,707, "Diagnostic and Screening Methods and Kits Associated with Proteolytic Activity." IP protection of this technology was also recently granted by the European Union. This technology will enable faster drug discovery by improving the ability to identify more selective drugs that modulate the handling of proteins associated with various disease states.

27 Jul 2010

Compound Management & Integrity conference to address challenges in improvement methodologies

An efficient and versatile compound management operation is essential for the success of all downstream processes in high throughput screening (HTS) and small molecule development. The 6th Compound Management & Integrity conference taking place September 20 - 22, 2010 will address issues concerned with improving both strategic and tactical aspects of compound management.

27 Jul 2010

Scientists develop carbon based nanoscale to detect single DNA molecules

Researchers at the University of Pennsylvania have developed a new, carbon-based nanoscale platform to electrically detect single DNA molecules.Using electric fields, the tiny DNA strands are pushed through nanoscale-sized, atomically thin pores in a graphene nanopore platform that ultimately may be important for fast electronic sequencing of the four chemical bases of DNA based on their unique electrical signature.The pores, burned into graphene membranes using electron beam technology, provide Penn physicists with electronic measurements of the translocation of DNA.

27 Jul 2010

Asuragen reports collaborative study results of advanced PCR-based molecular profiling of FMR1 gene

Asuragen, Inc. announced today the results from two collaborative studies, one with the University of California Davis M.I.N.D. Institute and another with Rush University Medical Center, that demonstrate comprehensive molecular profiling of the Fragile X Mental Retardation (FMR1) gene using advanced PCR-based methods.

26 Jul 2010

High Throughput News and Research

World Fusion creates sequence analysis service center with bioinformatics infrastructure

Chronix Biomedical expands biomarker development capabilities with installation of DNA mass sequencer

Scientists find epigenetic landscape map for tissue differentiation

CLC bio, PSSC Labs announce new turnkey solution for full-genome assembly and analysis

Researchers find transposons determine differences in physical traits, disease risks

Ohio State University procures IonFlux 16 high throughput automated patch clamp instrument

Protagen granted Notice of Allowance in Japan for key method patent for identifying and selecting clones

UCSF researchers discover new technology purifying special types of stem cells

WaferGen launches SmartChip System for discovery, validation of biomarkers

Sigma-Aldrich, NHLBI and BU collaborate in atherosclerotic cardiovascular disease research

BCM collaborates with Roche NimbleGen for high throughput exome capture technology

Biotage launches Isolera ELSD-1080 evaporative light-scattering detector for flash purification

Thermo Fisher Scientific introduces low evaporation plates for cell culture and high content analysis

Redpoint Bio issued patent that covers high-throughput screening technology

Integral Molecular receives patent for Lipoparticle membrane protein technology

Affymetrix to develop, commercialize Axiom Chinese myDesign Genotyping Array

Progenra receives Official Notice of Allowance for screening platform

Compound Management & Integrity conference to address challenges in improvement methodologies

Scientists develop carbon based nanoscale to detect single DNA molecules

Asuragen reports collaborative study results of advanced PCR-based molecular profiling of FMR1 gene

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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