Human Leukocyte Antigen News and Research

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Key insights into immune responses after COVID-19 vaccination in Indigenous people

Researchers evaluated immune responses to COVID-19 BNT162b2 mRNA vaccinations among Indigenous Australian First Nations (FN) individuals by comorbidity and ethnicity.

1 Jun 2023

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Researchers develop a lipid nanoparticle-formulated mRNA-based antigen encoding three SARS-CoV-2 peptides derived from non-structural proteins.

25 May 2023

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Research uncovers the association between multiple sclerosis (MS) and antibody reactivity to specific amino acids in CRYAB, along with the increased risk when combined with high EBNA1 responses. The study provides evidence of antibody and T cell cross-reactivity between EBNA1 and CRYAB, highlighting the role of EBV adaptive immune responses in MS development.

21 May 2023

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.

17 May 2023

Cedars-Sinai performs a record-setting number of solid organ transplants in 2022

As the nation takes notice of the importance of organ donations during April, National Donate Life Month, Cedars-Sinai is reporting a record-setting year for calendar year 2022.

25 Apr 2023

T cell-mediated recognition of conserved bacterial epitope generates broad immunity

Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity.

25 Apr 2023

Pregnant women show unique immune response to COVID-19

Researchers compare the adaptive, innate, and humoral immune responses between pregnant and non-pregnant women with COVID-19.

16 Apr 2023

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Researchers analyzed data on the association between intestinal microbiome dysbiosis and rheumatoid arthritis.

6 Apr 2023

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

Researchers explored the correlation between autoimmunity and obesity.

3 Apr 2023

The breadth of immune responses following COVID-19 vaccination in hematology patients with diseases and treatments impacting B cell immunity

A study published in Cell Reports Medicine describes that COVID-19 vaccines induce strong T cell response in blood cancer patients, irrespective of antibody response and B cell numbers.

30 Mar 2023

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

In a recent study posted to the bioRxiv* preprint server, researchers in Italy and the United States evaluated the efficacy and immunogenicity of an adjuvanted tetravalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit 1 (S1) COVID-19 vaccine.

21 Mar 2023

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

Researchers immunophenotyped T lymphocyte responses among unvaccinated individuals, representative of the entire spectrum of the clinical presentation of COVID-19.

28 Feb 2023

Study findings likely to guide the design of engineered TAPBPR variants with tailored HLA specificity

Researchers at Children's Hospital of Philadelphia (CHOP) have identified variants of a chaperone molecule that optimizes the binding and presentation of foreign antigens across the human population, which could open the door to numerous applications where robust presentation to the immune system is important, including cell therapy and immunization. The findings were published today in Science Advances.

24 Feb 2023

Human Leukocyte Antigen News and Research

Key insights into immune responses after COVID-19 vaccination in Indigenous people

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Novel computational platform can expand the pool of cancer immunotherapy targets

Cedars-Sinai performs a record-setting number of solid organ transplants in 2022

T cell-mediated recognition of conserved bacterial epitope generates broad immunity

Pregnant women show unique immune response to COVID-19

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

The breadth of immune responses following COVID-19 vaccination in hematology patients with diseases and treatments impacting B cell immunity

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

Study findings likely to guide the design of engineered TAPBPR variants with tailored HLA specificity

Genetic features of the immune system linked to a person's ability to resist new COVID-19 variants

The possible role of the endometrial microbiome as an immune modulator in the phase of implantation and during pregnancy

Proteomics reveals a distinct IFN-driven plasma cytokine response to COVID-19 in infants and young children

Study reviews mechanistic data on new methods of allergy prevention and treatment

New analysis improves the scientific community's understanding of COVID-19 immunity

Exploring T cell responses during COVID-19 breakthrough infection

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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