Human Leukocyte Antigen News and Research

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Analysis of Fcg Receptor haplotypes in rheumatoid arthritis

People with a specific combination of variants of two genes, encoding two different receptors for the antibody Fc gamma, are three times more likely to develop rheumatoid arthritis than individuals with different variant combinations.

28 Nov 2005

Fc gamma receptor gene variants associated with rheumatoid arthritis

10 Nov 2005

Diversity of HLA genotypes in humans is shaped to a significant degree by pathogens

The great physical diversity that evolution has forged in human beings is in evidence wherever we look, but the genes exhibiting the greatest diversity at the DNA level happen to function in a wholly invisible process: immunity. Genes encoding the Human Leukocyte Antigen (HLA) proteins are among the most diverse in the human genome, and scientists have proposed a number of hypotheses to explain why.

6 Jun 2005

Genetic markers implicated in fatal side effects of schizophrenia drug

Genaissance Pharmaceuticals today announced results from its CARING (Clozapine and Agranulocytosis Relationships Investigated by Genetics) study, reporting the discovery of genetic markers that the Company believes predict who is at risk of developing clozapine-induced agranulocytosis

20 Dec 2004

Discovery of key immune system molecules that helps determine how effectively a person resists HIV infection

A team of researchers based partly in South Africa has identified a key set of immune system molecules that helps determine how effectively a person resists infection with human immunodeficiency virus (HIV).

8 Dec 2004

Parental human leukocyte antigen genes linked to preterm delivery

The transmission of Human Leukocyte Antigen (HLA) genes may play a significant role in the risk of preterm delivery, according to a study in the September issue of Obstetrics and Gynecology.

31 Aug 2004

Gene associated with susceptibility to developing type 1 diabetes

A new gene mutation identified by researchers at Baylor College of Medicine in Houston is part of the constellation of genes associated with susceptibility to developing type 1 diabetes. It could also play a role in the devastating complications of diabetes such as kidney failure.

23 Jul 2004

Embryo testing could produce babies who might aid sick siblings

Parents with a child requiring stem cell transplantation can have genetic testing done on embryos prior to implantation to determine if the tissue type matches and the ensuing offspring could potentially serve as a donor to the affected child, according to a study in the May 5 issue of The Journal of the American Medical Association (JAMA).

5 May 2004

A promising new therapy for rheumatoid arthritis

A promising new therapy for rheumatoid arthritis (RA) developed by researchers at the University of California, San Diego (UCSD) School of Medicine re-educates the body's immune system to prevent an attack against healthy joint tissue.

21 Apr 2004

Gene of immune system linked to severe adverse drug reaction called Stevens-Johnson syndrome (SJS)

In a study of Han Chinese patients, researchers have for the first time directly linked a gene of the immune system to a severe adverse drug reaction called Stevens-Johnson syndrome (SJS), according to a Duke University Medical Center medical geneticist and collaborators in Taiwan.

1 Apr 2004