Human Leukocyte Antigen News and Research

RSS

Study points to one cause of higher rates of transplanted kidney rejection in blacks

A Johns Hopkins research team reports it may have an explanation for at least some of the higher organ rejection rates seen among black - as compared to white - kidney transplant recipients.

31 Aug 2008

Statistical modeling improves quality of laboratory data

Many areas of research and medicine rely critically upon knowing a person's individual immune system proteins, as they determine an individual's ability to fight disease or mistakenly attack their own tissues.

1 Mar 2008

Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs

After a transplant surgery, anti-rejection drugs for the organ recipient are a must, but with prolonged use can have serious side effects, including infections, heart disease and cancer.

24 Jan 2008

Experimental procedure induces tolerance to mismatched kidney transplants

Four of five patients participating in a trial of an experimental protocol designed to induce immune tolerance to HLA-mismatched kidney transplants have been able to discontinue immunosuppressive drugs.

24 Jan 2008

Role of genetics in multiple sclerosis

New research announced this week has found an association between certain genes and the severity of multiple sclerosis (MS).

10 Dec 2007

Discovery of way to match pathogens to their antibodies

The search for a vaccination against HIV has been in progress since 1984, with very little success.

15 Oct 2007

Omega-3 fatty acids may reduce type 1 diabetes risk in children

According to a new study by researchers in the United States children at risk of developing type 1 diabetes may be able to lessen that risk by consuming omega-3 fatty acids in their diet.

26 Sep 2007

Omega-3 fatty acids linked to decreased risk of type 1 diabetes

Preliminary research suggests that in children at increased risk for type 1 diabetes, dietary intake of omega-3 fatty acids was associated with a reduced risk of pancreatic islet autoimmunity, which is linked to the development of diabetes, according to an article in the Sept. 26 issue of JAMA.

25 Sep 2007

First case of successful ovarian tissue transplantation between two, nonidentical sisters

A woman, whose ovaries had failed due to damage caused by chemotherapy and radiotherapy, has received a successful ovarian transplant from her genetically non-identical sister.

3 Aug 2007

Woman has successful ovarian transplant from her sister

A woman whose ovaries were damaged by chemotherapy and radiotherapy, has received a successful ovarian transplant from her sister.

1 Aug 2007

Three gene variants discovered that help fight HIV

An international team of researchers has identified three gene variants in the DNA of 486 people infected with HIV that appear to have helped some of the patients fight off the virus and delay the onset of full-blown AIDS.

20 Jul 2007

New tumor antigen found with new cloning technique

In recent years, researchers have worked to develop a number of vaccines to help the immune system fight tumors.

16 Apr 2007

Researchers identify genetic risk for type 1 diabetes

A discovery at the Barbara Davis Center for Childhood Diabetes has identified a genetic risk for type 1 diabetes three to four times higher than previously thought possible.

4 Sep 2006

Natural mechanism protecting tissue allografts from rejection

A molecule expressed during pregnancy seems to turn down the immune system, making it more tolerant of welcome visitors such as a fetus or maybe a transplanted heart, researchers say.

10 Jul 2006

Inefficient cytotoxic T lymphocyte mediated killing of HIV-1 infected cells in vivo

HIV attacks the immune system by infecting and killing helper T lymphocytes (also called CD4 T cells), the white blood cells responsible for mobilizing the mediators of an immune response.

15 Mar 2006

Analysis of Fcg Receptor haplotypes in rheumatoid arthritis

People with a specific combination of variants of two genes, encoding two different receptors for the antibody Fc gamma, are three times more likely to develop rheumatoid arthritis than individuals with different variant combinations.

28 Nov 2005

Fc gamma receptor gene variants associated with rheumatoid arthritis

10 Nov 2005

Diversity of HLA genotypes in humans is shaped to a significant degree by pathogens

The great physical diversity that evolution has forged in human beings is in evidence wherever we look, but the genes exhibiting the greatest diversity at the DNA level happen to function in a wholly invisible process: immunity. Genes encoding the Human Leukocyte Antigen (HLA) proteins are among the most diverse in the human genome, and scientists have proposed a number of hypotheses to explain why.

6 Jun 2005

Genetic markers implicated in fatal side effects of schizophrenia drug

Genaissance Pharmaceuticals today announced results from its CARING (Clozapine and Agranulocytosis Relationships Investigated by Genetics) study, reporting the discovery of genetic markers that the Company believes predict who is at risk of developing clozapine-induced agranulocytosis

20 Dec 2004

Discovery of key immune system molecules that helps determine how effectively a person resists HIV infection

A team of researchers based partly in South Africa has identified a key set of immune system molecules that helps determine how effectively a person resists infection with human immunodeficiency virus (HIV).

8 Dec 2004