Hypersensitivity is an exaggerated response by the immune system to a drug or other substance.
Researchers investigated the selective activity of sigmoid 2 receptor (σ2R) or transmembrane protein 97 (TMEM97) ligands on murine neuropathic pain models, their effects on nociceptive neurons and the mechanism of action after 24 hours.
Among the most difficult types of pain to alleviate is neuropathic pain, pain that is usually caused by damage to nerves in various body tissues, including skin, muscle and joints.
Researchers review the low FODMAP diet's mechanisms in managing IBS, highlighting its efficacy and challenges in dietary implementation for symptom relief.
Low back pain is a major cause of disability around the globe, with more than 570 million people affected.
The major disorders of gut-brain interactions (DGBIs).
A method to design vaccines for highly variable viruses like the hepatitis C virus.
Researchers conducted a clinical trial on the effects of dapagliflozin on the urinary albumin-to-creatinine ratio (UACR) in patients with heart failure (HF) and type 2 diabetes mellitus (T2D).
Researchers at Michigan State University may have discovered why visceral pain is so common in people who have experienced inflammation in their guts, including patients with irritable bowel syndrome, or IBS.
Many disorders are caused by genetic variants; to make matters worse, the genetic origin of most disorders remains unknown.
An existing drug that targets senescent, or sleeping cells could provide the answer to treating lower back pain, according to a new study.
Toxicity assessments of monellin and brazzein.
The causal links between pro-inflammatory cytokine expression and migraine.
In an analysis of published prospective studies of people of all ages with confirmed SARS-CoV-2 infection who were followed for at least 12 months, pre-existing allergic conditions were linked to higher risks of experiencing long-term symptoms associated with COVID-19, or Long-COVID.
Researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced headaches.
The positive effects and adverse reactions of spices, dietary fiber, and medicinal herbs for pediatric patients with IBS.
The study uses a non-human primate model to explore the link between long-COVID and disruptions in glucose metabolism, finding a positive correlation. Vaccination appeared to improve glycemic control, suggesting a possible role in managing long-COVID symptoms.
Researchers in Italy delve into how changes in gut microbiota during the first 1000 days of life can influence the onset of food allergies in children. The study sheds light on various factors such as birth methods, breastfeeding, and antibiotic use that impact gut health, highlighting the need for more research on effective interventions for allergy prevention.
A recent study in the Nutrients journal employs bibliometrics to explore how nutrition impacts the relationship between gut microbiota and chronic pain. The research highlights the potential of probiotics and prebiotics in managing pain conditions and underscores the need for further studies to understand the interplay between diet, gut health, and chronic pain.
Novavax, Inc., a global company advancing protein-based vaccines with its novel Matrix-M™ adjuvant, today announced that its updated protein-based XBB COVID vaccine candidate induced neutralizing antibody responses to the EG.5.1 and XBB.1.16.6 subvariants in small animal and non-human primate studies.
Researchers investigated alpha-gal syndrome (AGS) prevalence and geographic distribution.