Hypothalamus News and Research

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The Hypothalamus is the area of the brain that controls body temperature, hunger, and thirst.

Scientists uncover genes that govern male and female behaviors

Hormones shape our bodies, make us fertile, excite our most basic urges, and as scientists have known for years, they govern the behaviors that separate men from women. But how? Now a team of scientists at the University of California, San Francisco (UCSF) has uncovered many genes influenced by the male and female sex hormones testosterone and estrogen that, in turn, govern several specific types of male and female behaviors in mice.

3 Feb 2012

FDA EMDAC to discuss Arena's lorcaserin NDA resubmission in second quarter

Arena Pharmaceuticals, Inc. and Eisai Inc. announced today that the US Food and Drug Administration (FDA) has notified Arena that an Endocrinologic and Metabolic Drugs Advisory Committee meeting to discuss the lorcaserin New Drug Application (NDA) resubmission will be held in the second quarter of 2012. Confirmation and details of the meeting will be published in the Federal Register.

2 Feb 2012

Potential way to block second wave of death from pneumonia treatment

An international research team may have found a way to block a second wave of death that can result from pneumonia treatment.

1 Feb 2012

Arena, Eisai collaborate in response to FDA's lorcaserin Complete Response Letter

Arena Pharmaceuticals, Inc. and Eisai Inc. announced today that Arena has submitted its response to the Complete Response Letter (CRL) issued by the US Food and Drug Administration (FDA) following review of the lorcaserin New Drug Application (NDA).

4 Jan 2012

Fatty food and brain damage: Study finds connection

US scientists found a sudden change to a high-fat diet triggered inflammation in a key area of rodent brains responsible for regulating body weight. The inflammation produced distinctive scarring similar to that seen in stroke patients - and that brain scarring was then observed in humans who were overweight.

28 Dec 2011

Obesity associated with hypothalamic injury

The number of people who suffer from one or more of the adverse complications of obesity, including type 2 diabetes and heart disease is rapidly increasing. Thus far, drugs designed to treat obesity have shown limited efficacy and have been associated with serious side effects.

28 Dec 2011

Epilepsy patients can benefit from gamma knife radiosurgery

Neurosurgeons continue to explore minimally invasive surgery with gamma radiation (gamma knife surgery / GKS) in the treatment of brain lesions causing seizures and epilepsy. Studies of the procedure are showing it to be an effective alternative to invasive microsurgery for hypothalamic hamartomas and other lesions that lie deep within the brain.

5 Dec 2011

Hypothalamus may be involved in generating laughter

Anecdotal evidence suggests that the hypothalamus, a structure lying deep within the brain may be involved in generating laughter. Gelastic epilepsy, a rare condition characterized by laughing seizures, is commonly the result of a congenital brain lesion within the hypothalamus.

5 Dec 2011

Transplantation of new neurons into damaged area of the brain could restore brain functions

Without neurons reacting to the blood leptin level, the brain does not control the feeling of hunger and fullness. This type of genetic defects results in severe obesity in humans and animals.

25 Nov 2011

Researchers take a step toward neuronal replacement therapy

A new study has revealed that immature neurons taken from healthy mouse embryos can repair damaged brain circuitry and partially normalize metabolism when transplanted into adult mice that have grown morbidly obese due to a genetic deficiency.

24 Nov 2011

Carefully selected young, healthy neurons can repair brain circuitry

Neuron transplants have repaired brain circuitry and substantially normalized function in mice with a brain disorder, an advance indicating that key areas of the mammalian brain are more reparable than was widely believed.

24 Nov 2011

Alzheimer’s disease progression and body weight may be linked: Study

There have been studies that show that people who are overweight in middle age are more likely to develop Alzheimer's disease decades later than people at normal weight. However some studies also show that people in the earliest stages of Alzheimer's disease are more likely to have a lower body mass index (BMI).

22 Nov 2011

Study examines link between early-stage Alzheimer's and lower BMI

Studies have shown that people who are overweight in middle age are more likely to develop Alzheimer's disease decades later than people at normal weight, yet researchers have also found that people in the earliest stages of Alzheimer's disease are more likely to have a lower body mass index (BMI). A current study examines this relationship between Alzheimer's disease and BMI.

22 Nov 2011

CUMC presents 2011 Naomi Berrie Award to UMDNJ researcher

Columbia University Medical Center (CUMC) presented the 2011 Naomi Berrie Award to Barry E. Levin, MD, a University of Medicine & Dentistry of New Jersey researcher whose work focuses on the mechanisms by which specialized metabolic-sensing neurons regulate glucose and energy homeostasis. Junior investigator Kazuhisa Watanabe, at Columbia University Medical Center, received a Berrie Fellow award.

22 Nov 2011

New clues about connections among fat, inflammation and insulin resistance

In a new study, scientists report that they substantially curbed weight gain, improved metabolism, and improved the efficacy of insulin in mice by engineering them to express a specific human enzyme in their fat tissue. Although the obesity prevention came at the significant cost of widespread inflammation, the research offers new clues about the connections among obesity, insulin resistance and type 2 diabetes, and inflammation.

14 Nov 2011

Brain plays a key role in regulating glucose metabolism in humans

Researchers at Albert Einstein College of Medicine of Yeshiva University have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans.

7 Nov 2011

Scientists discover neurons responsible for light-induced arousal response

Bright light arouses us. Bright light makes it easier to stay awake. Very bright light not only arouses us but is known to have antidepressant effects. Conversely, dark rooms can make us sleepy. It's the reason some people use masks to make sure light doesn't wake them while they sleep.

4 Nov 2011

Scientists reveal how resistance to hormone leptin develops

The effects of obesity - both on our bodies and on the health budget - are well known, and now, scientists are getting closer to understanding how the disease progresses, providing clues for future treatments.

15 Oct 2011

Reducing levels of protein FKBP51 may yield new antidepressant therapies

Decreasing expression of a protein associated with susceptibility to depression made old mice resistant to depressive-like behavior while improving their hormonal response to stress, a study led by researchers at the University of South Florida found. The lack of this protein, FKBP51, did not adversely affect their memory, learning, or basic motor functions.

17 Sep 2011

Elevating free radical levels suppresses appetite in obese mice

Obesity is growing at alarming rates worldwide, and the biggest culprit is overeating. In a study of brain circuits that control hunger and satiety, Yale School of Medicine researchers have found that molecular mechanisms controlling free radicals-molecules tied to aging and tissue damage-are at the heart of increased appetite in diet-induced obesity.

29 Aug 2011