Hypoxia News and Research

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Hypoxia is a condition in which there is a decrease in the oxygen supply to a tissue. In cancer treatment, the level of hypoxia in a tumor may help predict the response of the tumor to the treatment.

Biomira files NDA for novel inhibitor of hypoxia-inducible factor-1 alpha

Biomira Inc. has announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration for PX-478. PX-478 has been shown in preclinical studies to inhibit hypoxia-inducible factor (HIF)-1 alpha, a protein that controls the transcription of a number of genes whose products are important for tumor growth and survival.

4 Jul 2007

Key mechanism identified by which the body regulates iron metabolism

Scientists at the University of California, San Diego (UCSD) have determined a key mechanism by which the body regulates iron metabolism, a discovery that may provide new approaches for the treatment of anemia.

23 Jun 2007

Breastfeeding may provide long-term protection against childhood sleep-related breathing disorder

A childhood sleep-related breathing disorder (SRBD) is known to have negative consequences on cognitive development, behavior, quality of life and utilization of health care resources.

14 Jun 2007

Combination therapy reduces tumor resistance to radiation

Radiation is used to treat a variety of tumors and the response of tumors to radiation is dependent on endothelial cell death, which in turn limits oxygen delivery to the tumor, causing hypoxia and tumor cell death.

8 Jun 2007

Link between mild infection and hypoxic apnoea

Apnoea and sudden infant death syndrome (SIDS) represent major medical concerns in the neonatal population, and infection may play a crucial role in their pathogenesis.

28 May 2007

Respiratory control in insects: integration from the gene to the organism

Because of new imaging technology, researchers are getting a better understanding of a physiological paradox: how insects, which have a respiratory system built to provide quick access to a lot of oxygen, can survive for days without it.

30 Apr 2007

Headaches may act like tiny transient strokes

Migraines may be doing more than causing people skull-splitting pain. Scientists have found evidence that the headaches may also be acting like tiny transient strokes, leaving parts of the brain starved for oxygen and altering the brain in significant ways.

30 Apr 2007

Smoking associated with worse outcomes in patients with prostate cancer treated by radical radiotherapy

A history of smoking is associated with an increased risk of metastatic disease in patients treated with radiotherapy (XRT) for prostate cancer (CaP), according to a report in the online version of the BJU International.

20 Apr 2007

Alcohol consumption linked to sleep-related breathing disorder in men

Increased usual alcohol consumption among men is associated with an increased risk of a mild or worse sleep-related breathing disorder (SRBD), according to a study published in the April 15th issue of the Journal of Clinical Sleep Medicine (JCSM).

16 Apr 2007

New insights into renal cell cancer

A new mouse model is providing valuable insight into the biochemical pathways that are associated with development of renal cysts and renal cell cancer.

10 Apr 2007

Researchers discover how cells fine-tune oxygen use

Researchers at Johns Hopkins have discovered how cells fine-tune their oxygen use to make do with whatever amount is available at the moment.

7 Apr 2007

Gene therapy shows promise as treatment for diseased lower limbs at risk for amputation

New research suggests that gene therapy is a safe treatment method to explore in patients whose lower limbs are at risk for amputation because of poor circulation caused by blocked blood vessels.

27 Feb 2007

Cancer Research Technology grants Waypharm option to novel platinum agents

Cancer Research Technology Limited (CRT), the cancer-focused development and commercialisation company, today announce that Waypharm S.A.S (Waypharm) has secured rights to evaluate Thioplatin a novel hypoxia-responsive platinum-based cancer therapy, from CRT.

5 Feb 2007

BACE 1 gene may hold the key to Alzheimer's

Canadian scientists have found a specific gene which they believe may hold the key to the degenerative brain disorder Alzheimer's disease.

21 Nov 2006

Kaposi's sarcoma-associated herpesvirus tricks cells to become tumors

Researchers at the University of Pennsylvania School of Medicine have discovered how the Kaposi's sarcoma-associated herpesvirus (KSHV) subverts a normal cell process in order to promote tumor growth.

8 Nov 2006

Victhom files provisional sleep apnea patent application

Victhom Human Bionics announced that, after a series of pilot animal studies on potential medical indications of its Closed Loop System (the CLS Neuromodulator).

19 Oct 2006

Sildenafil boosts high altitude exercise up to 45% for some cyclists

Sildenafil (Viagra) significantly improved the cardiovascular and exercise performance measures of trained cyclists at high altitude, mostly because the drug helped some participants improve a lot -- up to 45% -- while others showed little change. Sildenafil provided no benefit at sea level.

5 Jul 2006