Hypoxia News and Research

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Hypoxia is a condition in which there is a decrease in the oxygen supply to a tissue. In cancer treatment, the level of hypoxia in a tumor may help predict the response of the tumor to the treatment.

Genzyme begins gene transfer trial for peripheral arterial disease

Genzyme Corporation announced today that the first patient has been treated in a new phase 2 clinical trial examining the safety and effectiveness of locally delivered gene transfer for patients with peripheral arterial disease.

24 Feb 2005

Researchers have identified a protein called HIF-2a, which is important in retina formation

Hoping to prevent blindness in premature babies, UT Southwestern Medical Center researchers have identified a protein that responds to oxygen levels in cells and tissues and also affects the developing eye.

22 Feb 2005

Newly discovered virus, New Haven coronavirus

A newly discovered virus may be responsible for many respiratory tract illnesses in infants and children, and may be associated with an important multi-organ disease whose cause has remained a mystery for decades, according to articles in the Feb. 15 issue of The Journal of Infectious Diseases, now available online.

19 Jan 2005

Discovery of gene related to p53 called Bnip3L that can also cause cell death

Researchers have known for a decade that the p53 tumor suppressor gene is important for killing cells as they proliferate under low-oxygen conditions inside tumors.

5 Jan 2005

Timing of radiation and antiangiogenic therapy impacts treatment effectiveness

Agents designed to attack blood vessels that feed a growing tumor are effective against tumor growth in laboratory experiments. However, results of early clinical trials with these inhibitors have not yet exhibited the same success observed in animal models.

20 Dec 2004

Controversial theory about how diabetes causes extensive tissue damage

A controversial theory about how diabetes causes extensive tissue damage will appear in the November issue of Diabetes. At stake in the heated debate over the theory are researchers' efforts to find new ways to reduce loss of vision, kidney failure, heart damage and other side effects of diabetes.

29 Oct 2004

Infection plays a larger role than lack of oxygen in premature infants with brain injury

Johns Hopkins researchers have dispelled the widespread belief among obstetricians that, in premature infants, brain injury results from a lack of oxygen, also called hypoxia, when, in fact, infection plays a larger role.

24 Oct 2004

No change in UK perinatal death rate from infections and prematurity in 20 years

Despite overall falls in UK rates of stillbirth and neonatal deaths over the past 20 years, deaths caused by infections and prematurity in multiple births have remained unchanged, reveals research in the Fetal and Neonatal Edition of the Archives of Disease in Childhood.

21 Oct 2004

Boosting the blood count in conjunction with radiation therapy doesn't improve survival for head and neck cancer patients

Boosting the blood count – in effect, curing anemia – in conjunction with radiation therapy won't help patients with head and neck cancer fare any better than with radiation alone, says a national study led by Jefferson Medical College researchers.

5 Oct 2004

Findings have implications for understanding psychiatric and neurological disease that affect the hippocampus

Spatial memory is more vulnerable than object recognition memory when damage occurs in the brain’s memory processing center, the hippocampus, according to memory specialists at the University of California, San Diego (UCSD) School of Medicine

27 Sep 2004

Significant relationships between laryngopharyngeal reflux and upper airway sensory impairment

Medical researchers have long suspected a relationship between gastro-esophageal reflux disease (GERD) and obstructive sleep apnea (OSA), two medical conditions which can have a deleterious effect on a patient¡¯s quality of life.

17 Sep 2004

Drug combo may have a greater impact on cancer development

Cancer researchers have long suggested that new targeted drugs may work best when paired with other therapies. In a new study published today in Cancer Research, scientists have taken some of the first steps to demonstrate this synergy in mouse and cell line models.

16 Sep 2004

Potential new drug for the treatment of sickle cell disease

The results were published in the June 2004 issue of The British Journal of Haematology (BJH). MX-1520 is a prodrug of vanillin, a very popular food additive generally regarded as safe (GRAS) by the FDA.

13 Sep 2004

University of Nottingham research developments could mean new drugs will reach cancer patients more quickly

A £3 million grant and the establishment of a specialized business unit that will help new treatments reach cancer patients more quickly, have underlined The University of Nottingham’s place at the forefront of cancer drug development.

2 Sep 2004

Researchers to conduct a series of studies on human circulation

Penn State College of Medicine researchers recently were awarded a five-year, $7 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health to conduct a series of studies on human circulation.

18 Aug 2004

Premature babies grow up to have a portion of the brain smaller than normal

Kids on a playground can be hard to tell apart. But those who were born significantly preterm may be struggling with a hidden handicap that sets them apart from their peers: specific areas of the brain that are smaller than normal, even years later.

9 Aug 2004

Study to begin to develop patient guidelines for the use of antidepressant medications in pregnancy and following birth

The University of Arizona department of psychiatry is conducting a first-of-its kind study to begin to develop patient guidelines for the use of antidepressant medications in pregnancy and following birth.

21 Jul 2004

Possible cure for sudden infant death syndrome (SIDS)

University of Chicago researchers may have found a crucial clue to understanding and ultimately eliminating sudden infant death syndrome, the leading cause of post-neonatal mortality in the United States.

9 Jul 2004

Potential new strategy for blocking tumor growth

Targeting a master molecule that helps cancer cells survive when blood oxygen levels are low may offer a potentially powerful strategy for blocking tumor growth, say researchers at The University of Texas M. D. Anderson Cancer Center.

16 Jun 2004

Results from study of Rituxan in rheumatoid arthritis show promise

Genentech, Inc., Biogen Idec and Roche have announced that the New England Journal of Medicine published the results of a Phase IIa study showing that two doses of Rituxan® (Rituximab), administered two weeks apart, improved symptoms in patients with moderate-to-severe rheumatoid arthritis (RA) for up to 48 weeks when combined with methotrexate (MTX), compared to MTX alone.