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Researchers discover biochemical agent responsible for blood pressure drop in sepsis

A study conducted by an international group of researchers has overturned the understanding of life-threatening inflammatory diseases such as sepsis, pointing to a biochemical agent that may be involved in the rapid decline in blood pressure that occurs in the advanced stage of sepsis and usually causes the patient's death. This discovery could pave the way for novel therapeutic approaches.

14 May 2019

Autophagy of dendritic cells supports T-cell anticancer activity

Autophagy contributes to the homeostasis of a cell and recently another function of autophagy has been reported. A KAIST research team found that the autophagy of dendritic cells supports T-cell anticancer activity.

13 May 2019

Scientists investigate function of AAPP in mosquito blood feeding

Biting insects use a range of tools when sucking blood from hosts to maximize their chances of a good meal.

13 May 2019

UT Southwestern study suggests why UTIs have high recurrence rate in postmenopausal women

A UT Southwestern study suggests why urinary tract infections have such a high recurrence rate in postmenopausal women - several species of bacteria can invade the bladder walls.

12 May 2019

Slow-release HIV vaccine shows promise in preclinical trials

A new slow-release vaccine has been shown to boost the immune system’s response to the HIV virus. The vaccine is given in small doses over a period of days, compared to one large dose.

10 May 2019

Researchers design promising cell-based regenerative therapy approach for periodontitis

Researchers have designed a safer, faster and cheaper cell-based regenerative therapy approach for the treatment of one of the most common human dental diseases, namely periodontitis.

10 May 2019

Researchers create ‘mini-guts’ to explore how gut epithelium respond to gluten in celiac patients

In pursuit of a novel tool for the research and treatment of celiac disease, scientists at the Mucosal Immunology and Biology Research Center at Massachusetts General Hospital have validated the use of intestinal organoids.

8 May 2019

Long-standing immunosuppressive drug reduces Zika birth defects in mice

In experiments with pregnant mice infected with the Zika virus, Johns Hopkins Medicine researchers report they have successfully used a long-standing immunosuppressive drug to diminish the rate of fetal deaths and birth defects in the mice's offspring.

From Johns Hopkins Medicine 7 May 2019

Research aims to keep astronauts healthy in space

Falling ill while traveling is an unfortunate yet common occurrence. Even a minor bug can ruin an entire trip. But for astronauts, getting sick on a long space voyage would have far more serious consequences than a little spoiled fun.

7 May 2019

Scientists discover biological barrier that keeps cancer at bay

Activins are proteins involved in a number of important biological functions, including the regulation of the menstrual cycle, cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function.

6 May 2019

Experts to present tumor DNA, breast and jaw reconstruction studies at PSRC annual meeting

The Plastic Surgery Research Council focuses on awareness surrounding compelling research relating to the field of plastic surgery.

3 May 2019

$30 million federal grant to accelerate chase for universal influenza vaccine

Cincinnati Children's Hospital Medical Center will use a $30 million federal grant--the second-largest the center has ever received--to accelerate the chase for one of medicine's most elusive goals: a universal influenza vaccine.

2 May 2019

Angiotensin receptor blockers could improve response to cancer immunotherapy

A research team led by investigators at Massachusetts General Hospital and the Massachusetts Institute of Technology has found that combining a specialized version of an antihypertension drug with immune checkpoint blockers could increase the effectiveness of cancer immunotherapies.

30 Apr 2019

Study describes new viral molecular evasion mechanism used by cytomegalovirus

A study published in the journal PLOS Pathogens describes a new viral molecular evasion mechanism used by cytomegalovirus to interfere in the immune response of the infected host.

30 Apr 2019

Measuring biomarkers in blood may help pinpoint newborns with HIE

Measuring a number of biomarkers over time that are produced as the body responds to inflammation and injury may help to pinpoint newborns who are more vulnerable to suffering lasting brain injury due to disrupted oxygen delivery and blood flow, according to research presented during the Pediatric Academic Societies 2019 Annual Meeting.

27 Apr 2019

TET proteins help regulate gene activity vital for normal antibody production

A family of cancer suppressive proteins, known as TET proteins, help regulate gene activity via their influence on chromosomal architecture. However, until now it wasn't entirely clear how genes were activated by TET proteins to make sure that cells perform their normal functions efficiently.

27 Apr 2019

CircRNAs bind to dsRNA-activated protein kinase which is linked to innate immunity

Covalently closed circular RNAs are produced by precursor mRNA back-splicing the exons of thousands of genes in eukaryotes.

26 Apr 2019

Dermcidin in human sweat may contribute to pathogenesis of hidradenitis suppurativa

Dermcidin, an anti-microbial peptide normally found in human sweat, may play a role in the pathogenesis of this chronic skin disease hidradenitis suppurativa, according to a research team from the George Washington University.

26 Apr 2019

New chemical synthesis strategy leads to identification of novel, simpler derivatives

A new chemical synthesis strategy to harvest the rich information found in natural products -- organic compounds isolated from natural sources -- has led to the identification of novel, simpler derivatives with potential to selectively protect neurons, important for neurodegenerative diseases like Alzheimer's disease, or to prevent the immune system from rejecting organ transplants, according to a Baylor University-led study.

25 Apr 2019

Pregnant women with type 1 diabetes are at greater risk of preterm birth

Pregnant women with type 1 diabetes are at increased risk of delivering their baby prematurely. The risk increases as blood sugar levels rise, however women who maintain the recommended levels also risk giving birth prematurely.

23 Apr 2019