Immune Response News and Research

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Researchers identify comprehensive guidelines for managing severe atopic dermatitis

A team of investigators from the University of Colorado College of Nursing at CU Anschutz Medical Campus and National Jewish Health has identified comprehensive guidelines for managing severe atopic dermatitis (AD), the most common form of eczema.

16 Jan 2019

New immune response regulators discovered

The discovery was published in the new iScience journal for interdisciplinary research by Cell Press. The newly discovered regulatory proteins differ significantly from the regulators in mouse immune cells which have been reported earlier. Some of the proteins, such as SATB1 regulating the transcription of several genes, function in the opposite way in human compared to mouse.

16 Jan 2019

Researchers identify MANF as a rejuvenating factor in parabiosis

Older mice who are surgically joined with young mice in order to share a common bloodstream get stronger and healthier, making parabiosis one of the hottest topics in age research. Publishing in Nature Metabolism, researchers from the Buck Institute report that MANF (mesencephalic astrocyte-derived neurotrophic factor) is one of the factors responsible for rejuvenating the transfused older mice.

16 Jan 2019

Scientists reveal key mechanism in worms that controls cell's response to stress

Scientists have revealed a key mechanism in worms that is involved in controlling the cell's response to stress, a study in eLife reports.

16 Jan 2019

DNA origami can accurately measure how antibodies interact with several antigens

Using DNA origami - DNA-based design of precise nanostructures - scientists at Karolinska Institutet in collaboration with researchers at University of Oslo, have been able to demonstrate the most accurate distance between densely packed antigens in order to get the strongest bond to antibodies in the immune system.

14 Jan 2019

Scientists find link between colitis and colon cancer

Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer.

14 Jan 2019

New potential immunotherapy target in pancreatic cancer identified

Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.

11 Jan 2019

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications.

11 Jan 2019

Study finds specific function of HIV protein that slows viral spread in early stages of infection

A study from a Massachusetts General Hospital research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection.

11 Jan 2019

Expression of a molecule in blood cells inversely predicts appearance of subclinical atherosclerosis

Earlier detection of cardiovascular disease is a step closer thanks to the findings of a research team at the Centro Nacional de Investigaciones Cardiovasculares led by Francisco Sánchez-Madrid and Pilar Martín.

10 Jan 2019

Neuropeptide Y may hold key to exacerbating severe influenza

Severe influenza virus infection is characterized by a strong inflammatory response and profuse viral replication in lungs. These viruses, such as the notorious avian flu, have a high rate of death and to date there are no effective treatments.

10 Jan 2019

High-performing MS device reaches new level in characterizing protein impurities

In response to current regulatory guidance a Mass Spectrometry-based Host Cell Protein detection approach with faster, more accurate and wider-ranging detection is essential.

10 Jan 2019

Schizophrenia patients have higher levels of antibodies against Epstein-Barr virus, study shows

New research from Johns Hopkins Medicine and Sheppard Pratt Health System shows that people in the study with schizophrenia also have higher levels of antibodies against the Epstein-Barr virus (EBV), a herpes virus that causes infectious mononucleosis, so-called mono.

9 Jan 2019

New mechanism of gene regulation involved in tumor progression discovered

Genes contain all the information needed for the functioning of cells, tissues, and organs in our body. Gene expression, meaning when and how are the genes being read and executed, is thoroughly regulated like an assembly line with several things happening one after another.

9 Jan 2019

Immune Response News and Research

Researchers identify comprehensive guidelines for managing severe atopic dermatitis

New immune response regulators discovered

Researchers identify MANF as a rejuvenating factor in parabiosis

Scientists reveal key mechanism in worms that controls cell's response to stress

DNA origami can accurately measure how antibodies interact with several antigens

Scientists find link between colitis and colon cancer

New potential immunotherapy target in pancreatic cancer identified

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

Study finds specific function of HIV protein that slows viral spread in early stages of infection

Expression of a molecule in blood cells inversely predicts appearance of subclinical atherosclerosis

Neuropeptide Y may hold key to exacerbating severe influenza

High-performing MS device reaches new level in characterizing protein impurities

Schizophrenia patients have higher levels of antibodies against Epstein-Barr virus, study shows

New mechanism of gene regulation involved in tumor progression discovered

New analytic method can precisely detect viral infections using immune responses

High-fat diets shown to increase blood pressure

Higher fat consumption appear to be bad for blood pressure in younger males and females

CytoReason enters into drug discovery collaboration agreement with Pfizer

Faulty immune receptor in HIV patients could be reason why many experience complications

Common food additive could cause celiac disease, review says

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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