Immune Response News and Research

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Study analyzes distribution of two cytokines in sections of carotid atherosclerotic plaques

Inflammation is currently a well-documented component of atheroslcerosis pathogenesis, which plays a role at each stage of the disease development.

6 Oct 2018

Researchers develop cancer vaccine platform to improve efficacy of oncolytic enveloped viruses

Researchers at the Faculty of Pharmacy have developed PeptiENV, a cancer vaccine platform, which can be used to improve the therapeutic efficacy of oncolytic enveloped viruses currently in clinical use.

6 Oct 2018

Researchers receive DoD grant to test efficacy of stem cell therapy for eye injuries

Researchers at the University of Illinois at Chicago have received a four-year, $5.25 million grant from the U.S. Department of Defense to lead a multi-site clinical trial to test the efficacy of a stem cell-based treatment for eye injuries.

5 Oct 2018

Vaxart to present new data from Phase 2 Challenge Study of H1 influenza oral tablet vaccine

Vaxart, Inc., a clinical-stage biotechnology company developing oral recombinant vaccines that are administered by tablet rather than by injection, announced it will present new data from the Phase 2 Challenge Study of its H1 influenza oral tablet vaccine at IDWeek 2018 in San Francisco on Saturday, October 6, 2018.

4 Oct 2018

Discovery opens door to new therapies for type 1 diabetes

Researchers at St Vincent’s Institute in Melbourne have identified a key target of the immune response that causes type 1 diabetes.

4 Oct 2018

Doctors use bacteriophages to treat patient with multi-drug resistant bacterial infection

The married professors were spending their Thanksgiving holiday in Egypt when the husband, Thomas L. Patterson, Ph.D., got very sick very quickly, experiencing fever, nausea and a racing heartbeat. By the time Patterson was accurately diagnosed with a highly multi-drug resistant bacterial infection, he was near death.

4 Oct 2018

RCIGM and IDbyDNA launch clinical trial to improve diagnostics for pediatric CNS infections

The Rady Children's Institute for Genomic Medicine and IDbyDNA, a metagenomics technology company translating microbial genomics into actionable information for healthcare providers, have launched a clinical trial to improve diagnostics for pediatric central nervous system infections.

3 Oct 2018

Combination approach appears to improve chemotherapy response, boost anti-tumor immunity

Scientists at the University of Toronto's Leslie Dan Faculty of Pharmacy have seen remarkable success combining tumor modulating nanoparticles with doxorubicin to enhance chemotherapy response in pre-clinical model breast cancer.

3 Oct 2018

Study identifies camelid nanobodies capable of blocking EGF in cancer cells

The natural world often provides the answer to unsolved medical problems. On this occasion, the solution to a challenge posed by cancer has come about from the immune system of camelids.

3 Oct 2018

Researchers caution that expediting HLH treatment may miss underlying cancers

Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis report in a new study that extra care should be taken to ensure an HLH diagnosis doesn't obscure possible underlying cancers.

1 Oct 2018

Gangrene-causing bacteria show promise as cancer treatment

Researchers have found that the bacteria responsible for causing gangrene could also be used to treat patients with certain cancers.

1 Oct 2018

$Bacterial therapy shows early clinical efficacy in patients with treatment-refractory solid tumors$

Bacterial therapy shows early clinical efficacy in patients with treatment-refractory solid tumors

A phase I clinical trial investigating the use of bacterial Clostridium novyi-NT spores as an injectable monotherapy had manageable toxicities and showed early clinical efficacy in patients with treatment-refractory solid tumor malignancies, according to data presented at the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival, held Sept. 30-Oct. 3.

30 Sep 2018

Promising vaccine may provide new treatment option for patients with HER2-positive cancers

Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers who had not previously been treated with a HER2-targeted therapeutic, according to data from a phase I clinical trial presented at the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival, held Sept. 30-Oct. 3.

30 Sep 2018

Synthetic DNA vaccine targets proteins overexpressed in several types of cancer

Scientists at The Wistar Institute have implemented a novel structurally designed synthetic DNA vaccine to simultaneously target multiple members of a family of proteins that are specifically overexpressed in several types of cancer.

28 Sep 2018

New combination therapy shows potential in treating incurable HPV-related cancers

A tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) in a phase II clinical trial led by investigators at The University of Texas MD Anderson Cancer Center and reported in JAMA Oncology.

28 Sep 2018

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

FLX Bio, Inc., a clinical-stage, biopharmaceutical company focused on the development of oral small-molecule drugs that target drivers of cancer and other immune-related disorders, today announced that the first patient has been treated in its Phase 1/2 clinical trial of FLX475 in patients with various advanced cancers. FLX475 is an oral, small molecule CCR4 antagonist that selectively inhibits migration of regulatory T cells into the tumor microenvironment.

27 Sep 2018

Immune Response News and Research

Study analyzes distribution of two cytokines in sections of carotid atherosclerotic plaques

Researchers develop cancer vaccine platform to improve efficacy of oncolytic enveloped viruses

Researchers receive DoD grant to test efficacy of stem cell therapy for eye injuries

Vaxart to present new data from Phase 2 Challenge Study of H1 influenza oral tablet vaccine

Discovery opens door to new therapies for type 1 diabetes

Doctors use bacteriophages to treat patient with multi-drug resistant bacterial infection

RCIGM and IDbyDNA launch clinical trial to improve diagnostics for pediatric CNS infections

Combination approach appears to improve chemotherapy response, boost anti-tumor immunity

Study identifies camelid nanobodies capable of blocking EGF in cancer cells

Researchers caution that expediting HLH treatment may miss underlying cancers

Gangrene-causing bacteria show promise as cancer treatment

Bacterial therapy shows early clinical efficacy in patients with treatment-refractory solid tumors

Promising vaccine may provide new treatment option for patients with HER2-positive cancers

Synthetic DNA vaccine targets proteins overexpressed in several types of cancer

New combination therapy shows potential in treating incurable HPV-related cancers

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

Scientists discover most important target of MRSA bacterial toxin and ways to neutralize it

Breastfeeding changes gene activity that regulates infant's response to stress

New approach to vaccine development and improved surveillance could help target deadly diseases

Research findings could bring relief to millions of cancer patients undergoing chemotherapy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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