Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Study reports on a novel property of antibodies, light chain coherence

Researchers investigate whether pairs of unrelated B-cells that have similar heavy chains also have the same light chains.

30 Oct 2022

Low-density granulocytes are phenotypically altered in people with long-COVID

In a recent study posted to the bioRxiv* preprint server, researchers characterized low-density granulocyte (LDG) neutrophil (NP) proportion among individuals up to 14 months post-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection.

28 Oct 2022

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, an international team of researchers leveraged the human light chain apoferritin protomer-derived MULTI-specific, multi-Affinity antibody (Multabody, MB) platform for the generation of broad and potent SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)-neutralizing antibodies (Abs).

27 Oct 2022

An unprecedented list of health-threatening fungi released by the WHO

The WHO fungal priority pathogens list ranks pathogens that pose a serious risk of morbidity and mortality in humans.

27 Oct 2022

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Researchers comparatively evaluated the neutralization antibody titers for SARS-CoV-2 Omicron VOC subvariants BA.1, BA.2, BA.4/5 among individuals with ancestral B.1 strain infections, vaccinated individuals, or with hybrid immunity from breakthrough infections and vaccinations with Delta or Gamma VOCs.

27 Oct 2022

Study explores the stability of monkeypox viral DNA in various body fluid samples

Researchers used laboratory diagnostic testing data of monkeypox cases and performed. They performed mathematical modeling to predict how long monkeypox viral deoxyribonucleic acid (DNA) remains detectable in different body fluid samples.

24 Oct 2022

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

Researchers investigated the efficacy of monovalent mRNA COVID-19 vaccines in immunocompromised adults during the Omicron dominance period starting December 2021.

24 Oct 2022

What are the complications, preventative measures, and treatments of ocular monkeypox?

A CDC report recently discussed ocular complications of monkeypox and discussed the treatments and preventative measures for ocular monkeypox.

20 Oct 2022

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

In a recent study posted to the bioRxiv* preprint server, researchers at Ohio State University and the University of Texas Medical Branch assessed the underlying mechanisms involved in the fusogenicity and endosomal entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants.

20 Oct 2022

Recent innovations in infectious disease diagnostics

A recent Clinical Biochemistry editorial reports the latest innovations in the field of infectious disease diagnostics.

17 Oct 2022

Did the risk of severe COVID-19 in the immunodeficient population of the UK change following vaccination deployment?

Researchers evaluated the changing risk of severe COVID-19 outcomes in individuals with primary and secondary immunodeficiencies in the context of COVID-19 vaccinations.

17 Oct 2022

Exploring molecular docking and molecular dynamics simulations as advanced tools for novel antiviral drug discovery

Researchers presented an overview of factors influencing emerging infectious diseases. They also highlighted the importance of molecular dynamic (MD) simulations and molecular docking (MDO) analysis for combating these diseases.

17 Oct 2022

COVID-19 outcomes among individuals with common variable immunodeficiency

Researchers evaluated the outcomes of COVID-19 in individuals with common variable immunodeficiency.

17 Oct 2022

Selective immunoglobulin A deficiency a risk factor for severe COVID-19

In a recent study published in The Journal of Allergy and Clinical Immunology, researchers in New Zealand gathered evidence to show that selective immunoglobulin A deficiency (sIgAD) is an understated risk factor for severe coronavirus disease 2019 (COVID-19).

17 Oct 2022

COVID-19 vaccines show favorable immunogenicity and efficacy in people living with HIV

In a recent study published in the International Journal of Infectious Diseases, researchers assessed the efficacy of coronavirus disease 2019 (COVID-19) vaccines in people living with human immunodeficiency virus (HIV).

16 Oct 2022

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

In a new study, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 drugs that compete for nucleotide-binding pockets (NBPs) of SARS-CoV-2 proteins.

11 Oct 2022

Immunodeficiency News and Research

Further Reading

Study reports on a novel property of antibodies, light chain coherence

Low-density granulocytes are phenotypically altered in people with long-COVID

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

An unprecedented list of health-threatening fungi released by the WHO

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Study explores the stability of monkeypox viral DNA in various body fluid samples

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

What are the complications, preventative measures, and treatments of ocular monkeypox?

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

Recent innovations in infectious disease diagnostics

Did the risk of severe COVID-19 in the immunodeficient population of the UK change following vaccination deployment?

Exploring molecular docking and molecular dynamics simulations as advanced tools for novel antiviral drug discovery

COVID-19 outcomes among individuals with common variable immunodeficiency

Selective immunoglobulin A deficiency a risk factor for severe COVID-19

COVID-19 vaccines show favorable immunogenicity and efficacy in people living with HIV

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

The involvement of minor intron-containing gene-encoded proteins in viral infections

Did telehealth appointments improve HIV care retention during the COVID-19 pandemic?

Myocarditis may be attributable to monkeypox infection

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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