Immunoglobulin News and Research

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Discovery may lead to new diagnostic tests for immunoglobulin A (IgA) deficiency and common variable immunodeficiency (CVID)

Defects in a single gene can result in two immune system disorders that leave affected individuals vulnerable to frequent or unusually severe infections, according to new findings reported in the August issue of Nature Genetics.

4 Aug 2005

Newly discovered gene mutation may account for many cases of immune deficiency

...in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the July issue of Nature Genetics. The discovery may lead to a new diagnostic test for these conditions, which make people highly susceptible to infections and often go unrecognized because of a lack of good tests.

11 Jul 2005

Scientists have discovered how C-reactive protein is able to access endothelial cells

For the first time, scientists have discovered how C-reactive protein, or CRP, is able to access endothelial cells. The UC Davis researchers' findings will be published in the July issue of Arteriosclerosis, Thrombosis, and Vascular Biology, one of the American Heart Association's leading journals.

27 Jun 2005

Protocol used to treat the first known survivor of rabies without prior vaccination published

The protocol used to treat the first known survivor of rabies without prior vaccination is published in the June 16, 2005, issue of the New England Journal of Medicine. It is hoped that this approach can be replicated, tested, and provide a guide for treating this fatal condition, especially in parts of the world where the incidence of rabies is rampant.

15 Jun 2005

Study shows using expanded critera donors is safe

Patients who had received livers from hepatitis B virus core antibody (HBcAb) positive (indicates prior exposure to hepatitis B) and/or hepatitis C virus (HCV) positive donors had similar graft and patient survival compared to patients who received HBcAb negative or HCV negative livers, according to a study by the University of Pittsburgh's Thomas E. Starzl Transplantation Institute.

25 May 2005

Certain combinations of genes increase the risk of developing cervical cancer

Certain combinations of genes that encode receptors on innate immune cells increase the risk of developing cervical cancer, according to a study by Mary Carrington and colleagues in the April 4 issue of The Journal of Experimental Medicine.

4 Apr 2005

Newly emerging illness, named staphylococcal purpura fulminans

Researchers at the University of Minnesota have identified a newly emerging illness, named staphylococcal purpura fulminans. The disease begins as a respiratory tract infection, which then is infected by Staphylococcus aureus.

30 Mar 2005

Specific test key to determine whether or not allergy symptoms are really allergy-related

Many people with allergy-like symptoms could get the test they need, and the right treatments for their symptoms, from their primary care physician if managed care practice guidelines encouraged the use of the test.

23 Mar 2005

FDA approval of Vaccinia Immune Globulin to treat adverse reactions to smallpox vaccination

Computer Sciences Corporation today announced that the U.S. Food and Drug Administration (FDA) has approved its Vaccinia Immune Globulin (VIGIV), an intravenous immune globulin, to treat rare adverse reactions to smallpox vaccination.

22 Feb 2005

FDA approves new smallpox vaccination

The U.S. Food and Drug Administration (FDA) has approved Vaccinia Immune Globulin Intravenous (VIGIV) - the first intravenous human plasma-derived product available to treat certain rare complications of smallpox vaccination.

20 Feb 2005

First program to apply RNA interference (RNAi) technology to asthma

Sirna Therapeutics, Inc. has announced the first program to apply RNA interference (RNAi) technology to asthma, a highly prevalent, chronic disease accounting for an estimated $13 billion in healthcare costs in the United States, a number which is forecast to grow considerably by the end of the decade.

7 Jan 2005

Somatic hypermutation (SHM) should prove to be extremely useful in directed protein evolution

Fascinated by the efficient way the human immune system generates a rapid response to create a near-infinite variety of antibodies, researchers have "hijacked" that machinery and used it to evolve a new type of fluorescent protein.

23 Dec 2004

Revlimid clinical data in newly diagnosed multiple myeloma presented

Celgene Corporation announced today that data evaluating clinical results on Revlimid (lenalidomide) as a new therapeutic approach for patients with newly diagnosed multiple myeloma (MM) was presented at the American Society of Hematology 46th Annual Meeting in San Diego.

7 Dec 2004

Study of infection prevention therapy for premature babies

Whether donated human antibodies can protect premature babies from a common and potentially dangerous bacterial infection is under study at the Medical College of Georgia Children’s Medical Center.

4 Nov 2004

Intravenous immunoglobulin therapy may reduce the risk of a second attack of symptoms related to multiple sclerosis

Anat Achiron, M.D., Ph.D., of Sheba Medical Center, Tel-Hashomer, Israel, and colleagues assessed the effect of IVIg treatment in patients after the first neurological event suggestive of MS and evaluated the occurrence of a second attack.

11 Oct 2004

Australian researchers hunt for eczema genes

The Queensland Institute of Medical Research (QIMR) is halfway through a major project examining possible genetic causes of atopic dermatitis which is the most common form of eczema.

6 Oct 2004

Immunoglobulins may help patients with Alzheimer’s

Immunoglobulins which are already being used to treat multiple sclerosis may also be able to help patients with Alzheimer’s. This, at least, is the finding of a pilot study on five patients at the University of Bonn.

20 Sep 2004

Immunoglobulins might be promising treatment for Alzheimer's disease

Intravenous immunoglobulin might offer a promising treatment for Alzheimer's disease, suggests preliminary research in the Journal of Neurology Neurosurgery and Psychiatry.

15 Sep 2004

Chickenpox (Varicella) vaccine has saved the U.S. hundreds of millions of dollars since its introduction

A new University of Michigan study has found that the Chickenpox (Varicella) vaccine has saved the U.S. hundreds of millions of dollars since its introduction in 1995 by preventing the kinds of severe cases that used to send children, teens and adults to the hospital.

7 Sep 2004

Researchers find how cancers, particularly lymphomas, develop and might be prevented

Researchers at Children's Hospital Boston have begun unraveling the mystery of how B lymphocytes - key infection-fighting cells in the body - are able to create many different kinds of specialized antibodies through selective gene mutations, while being protected from random mutations that could give rise to cancers.

23 Aug 2004