Immunomodulatory News and Research

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FDA approved PDE4 inhibitor roflumilast for atopic dermatitis

On July 9th, 2024, the U.S. FDA approved Arcutis Biotherapeutics' ZORYVE® (roflumilast) for treating atopic dermatitis (AD), the most common type of eczema affecting millions in the U.S. This once-daily, steroid-free cream could become a new standard of care for AD.

From Sino Biological Inc. 12 Jul 2024

Researchers identify molecular processes crucial for the maturation of Group 2 innate lymphoid cells

Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.

11 Jul 2024

How Aloe vera's medicinal properties make it essential in medicine, cosmetics, and food products

Comprehensive review highlights Aloe vera's versatile biological activities and its potential applications in medicine and cosmetics while addressing its safety concerns.

11 Jul 2024

PVP-037: A novel imidazopyrimidine adjuvant enhancing vaccine immune responses

Many vaccines are only partially effective, have waning efficacy, or do not work well in the very young or the very old.

3 Jul 2024

New study links psoriasis severity to skin microbiome dysbiosis

A multi-omics analysis of host-microbe interactions in psoriasis.

28 Jun 2024

Ashwagandha boosts memory and mood in clinical trial

A clinical trial found that acute and 30-day Ashwagandha supplementation improves cognitive function and mood markers, showing significant benefits in memory, attention, and well-being without adverse effects.

10 Jun 2024

Curcumin nanoparticles show promise in treating neurodegenerative diseases

Review demonstrates curcumin's neuroprotective effects in neurodegenerative diseases, enhancing its potential through innovative nanoparticle formulations. This advancement could significantly improve treatments for diseases like Parkinson's, Alzheimer's, and Multiple Sclerosis.

6 Jun 2024

Does diet influence the onset of multiple sclerosis?

A recent study using the UK Biobank data indicates that a healthy diet, including moderate fatty fish and alcohol consumption, can reduce the risk of multiple sclerosis (MS) onset.

5 Jun 2024

Evolving treatment paradigms in multiple myeloma could improve patient outcomes

The treatment landscape for multiple myeloma, the second most common blood cancer, is shifting rapidly, with newly diagnosed patients increasingly being treated with a four-part drug combination that includes a new immunotherapy agent.

24 May 2024

Study reveals ferroptosis as a major driver of severe COVID-19 lung damage

Ferroptosis, an iron-dependent cell death mechanism, is identified as a key factor in severe COVID-19 lung disease, suggesting potential new therapeutic targets.

22 May 2024

Can vitamin D3 supplementation reduce COVID-19 severity?

The effectiveness of Vitamin D3 supplementation in reducing intensive care unit admissions.

10 May 2024

Bacterial fatty acid metabolite identified as key player in immune regulation

Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health.-

7 May 2024

Inflammatory disease not major risk factors for severe COVID-19, focus on comorbidities urged

Severe coronavirus disease 2019 (COVID-19) outcomes in patients with immune-mediated inflammatory diseases (IMIDs).

3 May 2024

Harnessing immune enhancement to combat drug-resistant tuberculosis

Experts are working on novel immune-enhancing therapies called host-directed therapies to use the body's own immune system to target tuberculosis, with hopes that they could tackle even the drug-resistant forms of the disease.

26 Apr 2024

Cinnamon, curcumin, and resveratrol show promise in diabetes inflammation fight

Researchers reviewed the impact of cinnamon, curcumin, and resveratrol on oxidative stress and inflammation in type 2 diabetes patients, highlighting their potential to improve metabolic regulation and reduce complications.

26 Apr 2024

Therapeutic potential of human umbilical cord-derived mesenchymal stem cells in Crohn’s disease

Whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could heal luminal ulcers in Crohn’s disease.

25 Apr 2024

Repurposed nasal antibiotic neomycin shows promise in preventing and treating respiratory viral infections

Intranasal administration of neomycin sulfate in murine models shows promise as a prophylactic and therapeutic agent against respiratory viruses like influenza A and SARS-CoV-2 by inducing interferon-stimulated gene (ISG) expression, independent of microbiota and interferon activation.

24 Apr 2024