Induced Pluripotent Stem Cells News and Research

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Scientists create world’s first model of pituitary disease using human iPS cells

Researchers at Kobe University's Graduate School of Medicine have developed the world's first congenital pituitary hypoplasia model using patient-derived iPS cells.

14 Feb 2020

New study describes inflammatory reaction in lab-developed human astrocytes

Astrocytes are neural cells with many important functions in the nervous system. The inflammation of these cells occurs in brain infections and neurodegenerative disorders, a process called astrogliosis.

14 Feb 2020

Growing eggs and sperm to treat infertility

Scientists at the University of California, Los Angeles, have reported, in the journal Cell Reports, the mechanism of how the very early precursor or stem cells which eventually give rise to the germ cells, eggs and sperm, are formed over the course of development. This could help create eggs and sperms under laboratory conditions to help infertile people who don’t have sperms, or eggs, for instance.

9 Feb 2020

New strategy uses iPSCs to regulate immune reaction to transplanted tissues

Scientists suggest a new strategy that uses induced pluripotent stem cells (iPSCs) to regulate immune reaction to transplanted tissues.

9 Feb 2020

Renal stem cells can be isolated from urine

Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the medical faculty of Heinrich Heine University-Duesseldorf under the directorship of Prof. Dr. James Adjaye have developed a protocol for the reproducible isolation and characterization of kidney stem cells, urine-derived renal progenitor cells (UdRPCs) from donors of distinct ages, gender and ethnicity.

4 Feb 2020

Gene-editing taken to advanced levels in human stem cells

A new study published in the journal Stem Cell Reports in January 2020 reports the use of an adaptation to a commonly used gene editing technology to achieve a more than 900% increase in efficiency.

30 Jan 2020

New strategy using organoids to study childhood brain tumors

A new study reports the creation of in vitro models of brain tumors in children using organoids derived from stem cells, which will help to screen new drugs for efficacy and thus improve the rate of drug development. The study, titled 'Modeling medulloblastoma in vivo and with human cerebellar organoids,' is published in the journal Nature Communications.

29 Jan 2020

Study suggests prenatal origin for ‘young’ Parkinson’s disease

A new study published in the journal Nature Medicine on January 2020 suggests that Parkinson’s disease developing before the age of 50 years could be due to an abnormality in certain brain cells that remains dormant until the age of onset of the disease. It also indicates the potential usefulness of a specific drug to prevent this by correcting the brain cell disorder.

27 Jan 2020

Parkinson's disease may affect brain cells before birth

People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to new Cedars-Sinai research. The research points to a drug that potentially might help correct these disease processes.

27 Jan 2020

Scientists use human stem cells to make pain-killing neurons

Researchers at the University of Sydney have used human stem cells to make pain-killing neurons that provide lasting relief in mice, without side effects, in a single treatment.

23 Jan 2020

Finding has major ramifications for ongoing drug development against MLL-rearranged leukemia

A massive research effort over more than a quarter century has tried to make personalized blood stem cells for use in treating leukemias, among many other uses.

17 Jan 2020

Boston researchers develop novel approach to generate intestinal organoids in vitro

Boston researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system.

11 Jan 2020

Advancement in reconstitution of the blood system from human pluripotent stem cells

The reconstitution of the blood system in humans holds great therapeutic potential to treat many disorders, like blood cancers, sickle-cell anemia and others.

31 Dec 2019

Chemical reprogramming of granulosa cells to form functional oocytes

By introducing a chemical cocktail to granulosa cells, researchers in China induced the cells to transform into functional oocytes in mice.

26 Dec 2019

Different mutations in a single gene can have myriad effects on a person's health

Mount Sinai researchers have found that different mutations in a single gene can have myriad effects on a person's health, suggesting that gene therapies may need to do more than just replenish the missing or dysfunctional protein the gene is supposed to encode, according to a study published in Nature Genetics in November.

18 Dec 2019