Inflammation News and Research

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Better way to model human immune system

Scientists at the University of Minnesota have developed a new way to study mice that better mimics the immune system of adult humans and which could significantly improve ways to test potential therapeutics. Published online today in the journal Nature, the researchers describe the limitations of laboratory mice for immunology research and reveal the benefits of what they are calling "dirty mice."

21 Apr 2016

TNF-alpha protein involved in autoimmune diseases may also promote tissue healing

As its name suggests, inflammatory bowel disease, which afflicts more than 1.6 million Americans, involves chronic inflammation of all or some of the digestive tract. An autoimmune disease known to have a strong genetic component, its symptoms are abdominal cramps, bloody diarrhea, and fever and, sometimes, weight loss. IBD, which is a group of inflammatory conditions, includes Crohn's disease and ulcerative colitis.

21 Apr 2016

MAILES study finds link between fatty diets and sleep

University of Adelaide researchers have found that men who consume diets high in fat are more likely to feel sleepy during the day, to report sleep problems at night, and are also more likely to suffer from sleep apnea.

21 Apr 2016

Non-invasive test to diagnose EoE could replace need for repeated endoscopy

A non-invasive test to diagnose and monitor an inflammatory disease that injures the esophagus - called eosinophilic esophagitis or EoE - would replace the need for repeated endoscopy for a growing number of children and adults with this relatively new condition.

21 Apr 2016

LAP defects may lead to lupus-like autoimmune disorder

A casual observation about size differences in mice has led to the discovery that defects in a process for digesting dead cells called LC3-associated phagocytosis (LAP) may lead to a lupus-like autoimmune disorder. St. Jude Children's Research Hospital scientists led the research, which appears as an advance online publication today in the scientific journal Nature.

21 Apr 2016

Specific oral microbiome linked to pancreatic cancer risk

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment. This is the main finding of a study led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center to be presented April 19 in New Orleans at the annual meeting of the American Association for Cancer Research.

20 Apr 2016

Scientists develop new drug for life-threatening lung disease treatment

Researchers are developing a new drug to treat life-threatening lung damage and breathing problems in people with severe infections like pneumonia, those undergoing certain cancer treatments and premature infants with underdeveloped, injury prone lungs.

20 Apr 2016

DKFZ researchers develop new methods to study disease-relevant changes in production of oxidants

There are many false beliefs and myths about the role of oxidants and antioxidants in the human body. Traditionally, oxidants are presented as harmful and antioxidants as health-promoting. However, scientists have known for many years that endogenous oxidants are essential chemical messengers that help keep up the functions of the organism.

20 Apr 2016

Aspirin use linked with reduced risk of developing bile duct cancer

A team of current and former Mayo Clinic researchers has discovered that aspirin use is associated with a significantly reduced risk of developing bile duct cancer, also called cholangiocarcinoma. The results are published in Hepatology.

20 Apr 2016

Small piece of detoxified E. coli wall makes mice lose natural sweet tooth, study finds

Putting just a tiny piece of the wall of detoxified E. coli into their gut make mice lose their natural sweet tooth, researchers report.

20 Apr 2016

NObreath®: the essential tool for World Asthma Day

Asthma UK found 120,000 asthma sufferers at risk from wrongly prescribed medication, while NICE found 30% of people with asthma suspected to be misdiagnosed.

From Bedfont® Scientific Ltd 20 Apr 2016

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology.

19 Apr 2016

Cyclodextrin offers potential new therapy for cardiovascular disease

An American mother's hunch might result in new treatments for patients who can't tolerate conventional cholesterol-lowering drugs.

19 Apr 2016

New therapy strategy for liver disease shows initial measureable success with norUrso

The new therapy strategy for primary sclerosing cholangitis, a liver disease that at present still cannot be cured with medication, shows initial measureable success with the nor-ursodeoxycholic acid (norUrso).

19 Apr 2016

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Asthma is an enormous public health problem that continues to grow larger, in part because scientists don't fully understand how it is caused. Existing therapies don't cure the disease and often don't even significantly alleviate the symptoms. Now, scientists from the Perelman School of Medicine at the University of Pennsylvania and Rutgers University have identified a biological pathway that potentially explains why current asthma therapies don't work well in many cases—and might be targeted to help those patients.

19 Apr 2016

Therapies based on alpha defensins could help treat rheumatoid arthritis

Arthritis and other inflammatory conditions could be helped by new insights into how the immune response is switched off.

19 Apr 2016

Specific intake levels of xanthohumol reduces obesity, cholesterol and elevated glucose

A recent study at Oregon State University has identified specific intake levels of xanthohumol, a natural flavonoid found in hops, that significantly improved some of the underlying markers of metabolic syndrome in laboratory animals and also reduced weight gain.

19 Apr 2016

Georgetown researchers report first case of Alzheimer's disease diagnosed in HIV-positive individual

Georgetown University researchers are reporting the first case of Alzheimer's disease diagnosed in an HIV-positive individual. The finding in a 71-year-old man triggers a realization about HIV survivors now reaching the age when Alzheimer's risk begins to escalate.

18 Apr 2016

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

A multi-institutional study led by a Massachusetts General Hospital investigator finds significant racial disparities in the risk that patients being treated for gout will develop a serious, sometimes life-threatening adverse reaction to the most commonly prescribed medication. The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

16 Apr 2016

Intestinal bacteria can be used to reduce cancer risk, reveals UCLA study

Researchers have shown that various types of intestinal bacteria might be factors in both causing and preventing obesity, and in other conditions and diseases. Now, a UCLA study suggests that it could also potentially be used to reduce the risk for some types of cancer.

16 Apr 2016

Inflammation News and Research

Better way to model human immune system

TNF-alpha protein involved in autoimmune diseases may also promote tissue healing

MAILES study finds link between fatty diets and sleep

Non-invasive test to diagnose EoE could replace need for repeated endoscopy

LAP defects may lead to lupus-like autoimmune disorder

Specific oral microbiome linked to pancreatic cancer risk

Scientists develop new drug for life-threatening lung disease treatment

DKFZ researchers develop new methods to study disease-relevant changes in production of oxidants

Aspirin use linked with reduced risk of developing bile duct cancer

Small piece of detoxified E. coli wall makes mice lose natural sweet tooth, study finds

NObreath®: the essential tool for World Asthma Day

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Cyclodextrin offers potential new therapy for cardiovascular disease

New therapy strategy for liver disease shows initial measureable success with norUrso

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Therapies based on alpha defensins could help treat rheumatoid arthritis

Specific intake levels of xanthohumol reduces obesity, cholesterol and elevated glucose

Georgetown researchers report first case of Alzheimer's disease diagnosed in HIV-positive individual

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

Intestinal bacteria can be used to reduce cancer risk, reveals UCLA study

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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