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Researchers measure brain metabolite levels in people with mild memory problems

Using strong and targeted but noninvasive magnets at specific sites in the brains of people with and without mild learning and memory problems, Johns Hopkins researchers report they were able to detect differences in the concentrations of brain chemicals that transmit messages between neurons.

20 Mar 2019

Scientists identify endogenous activator of sigma-1 receptors in human cells

Cells communicate through complex mechanisms that typically involve receptors and ligands that bind to them. Endogenous ligands, produced by the body, have been identified for the vast majority of cellular receptors, helping explain receptor existence and function. But in the case of sigma-1 receptors, which interact with a diverse array of psychoactive drugs, an endogenous ligand has remained elusive.

14 Jan 2019

Study: Atg2 tethers pre-autophagosomal membrane to endoplasmic reticulum during autophagosome formation

Postdoctoral Researcher Tetsuya Kotani, Associate Professor Hitoshi Nakatogawa, Honorary Professor Yoshinori Ohsumi and colleagues at Tokyo Institute of Technology have analyzed the Atg protein Atg2, whose function had been completely unknown, and have discovered that Atg2 tethers the pre-autophagosomal membrane to the endoplasmic reticulum during autophagosome formation.

23 Oct 2018

Research reveals new details of HIV life cycle

Research by a multi-institutional team, including two members from the University of Delaware, has revealed new details about the HIV virus capsid structure and how it develops.

5 Oct 2018

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

HIV-1 replicates in ninja-like ways. The virus slips through the membrane of vital white blood cells. Inside, HIV-1 copies its genes and scavenges parts to build a protective bubble for its copies.

10 Aug 2018

New approach could provide objective and easy-to-obtain measure of dietary adherence

An analysis of small molecules called "metabolites" in a blood sample may be used to determine whether a person is following a prescribed diet, scientists at Johns Hopkins Bloomberg School of Public Health have shown.

20 Jun 2018

Study unravels how nuclear pore complexes transport mRNAs out of the nucleus

Standing guard between a cell's nucleus and its main chamber, called the cytoplasm, are thousands of behemoth protein structures called nuclear pore complexes, or NPCs.

13 Jun 2018

Measurement of tumor's metabolic activity could help determine prostate cancer prognosis

A new approach to analyzing prostate gland tissue may help address a major challenge in treating prostate cancer - determining which tumors are unlikely to progress and which could be life threatening and require treatment.

27 Mar 2018

Cortisol mediates communication between gut bacteria and brain metabolites, study suggests

Gut microbes have been in the news a lot lately. Recent studies show they can influence human health, behavior, and certain neurological disorders, such as autism.

21 Aug 2017

Study seeks to understand genetic synergy in cleft palate

Like all of the individual elements of fetal development, palate growth is a marvel of nature. In part of this process, ledges of tissue on the sides of the face grow downwards on each side of the tongue, then upward, fusing at the midline at the top of the mouth.

19 Jul 2017

Phase 2 clinical study examines Alzheimer's disease drug to treat adults with Down syndrome

A phase 2 clinical trial in young adults with Down syndrome of a drug being investigated for the treatment of Alzheimer's disease supports further investigation of its potential.

1 Jun 2017

Atomic resolution structure of key molecule may contribute to drug discovery for devastating conditions

Culminating a nearly 10 year effort, researchers have determined the atomic resolution structure of a key molecule that translates signals from a cell's local environment into a language that the cell can understand and use.

18 Apr 2017

Research suggests new type of congenital muscular dystrophy

A newly discovered mutation in the INPP5K gene, which leads to short stature, muscle weakness, intellectual disability, and cataracts, suggests a new type of congenital muscular dystrophy.

10 Feb 2017

How does the brain control appetite?

Energy balance between energy intake and expenditure in our bodies is important for maintaining energy homeostasis to keep our bodies functioning properly. The appetite determines how much we eat, the energy intake, by communication between the brain and body.

4 Jan 2017

Collapse of MAM is common pathological hallmark to certain inherited forms of ALS

Amyotrophic lateral sclerosis (ALS) is an adult onset, fetal neurodegenerative disease that selectively affects motor neurons.

8 Nov 2016

TSRI scientists identify new therapeutic target to combat obesity and type 2 diabetes

In a series of studies led by Assistant Professor Anutosh Chakraborty of The Scripps Research Institute Florida campus, scientists have identified a key protein that promotes fat accumulation in animal models by slowing the breakdown and expenditure of fat and encouraging weight gain.

12 Oct 2016

Inositol News and Research

Researchers measure brain metabolite levels in people with mild memory problems

Scientists identify endogenous activator of sigma-1 receptors in human cells

Study: Atg2 tethers pre-autophagosomal membrane to endoplasmic reticulum during autophagosome formation

Research reveals new details of HIV life cycle

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

New approach could provide objective and easy-to-obtain measure of dietary adherence

Study unravels how nuclear pore complexes transport mRNAs out of the nucleus

Measurement of tumor's metabolic activity could help determine prostate cancer prognosis

Cortisol mediates communication between gut bacteria and brain metabolites, study suggests

Study seeks to understand genetic synergy in cleft palate

Phase 2 clinical study examines Alzheimer's disease drug to treat adults with Down syndrome

Atomic resolution structure of key molecule may contribute to drug discovery for devastating conditions

Research suggests new type of congenital muscular dystrophy

How does the brain control appetite?

Collapse of MAM is common pathological hallmark to certain inherited forms of ALS

TSRI scientists identify new therapeutic target to combat obesity and type 2 diabetes

Nutritional supplements can enhance effectiveness of antidepressants

Study on HDAC enzymes could lead to development of better drugs for treatment of cancer, Alzheimer’s

MR may detect earliest Alzheimer's brain changes

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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