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SARS-CoV-2 infection enhances vaccine-induced immunological memory against spike protein

Researchers assess SARS-CoV-2 spike protein-specific immunological memory among unvaccinated and vaccinated convalescents.

22 Mar 2023

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

In a recent study posted to the bioRxiv* preprint server, researchers in Italy and the United States evaluated the efficacy and immunogenicity of an adjuvanted tetravalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit 1 (S1) COVID-19 vaccine.

21 Mar 2023

Childhood common colds help protect against COVID-19

In a recent study published in the Proceedings of the National Academy of Sciences, researchers assessed the association between cross-reactive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) CD4+ T cells generation and age.

20 Mar 2023

Real-world studies show efficacy, safety of BLV monotherapy in patients with HDV-related compensated cirrhosis

In 2020, bulevirtide (BLV) was conditionally approved for treating chronic hepatitis delta (CHD), an inflammation of the liver caused by hepatitis D virus (HDV).

20 Mar 2023

Elevated mucosal immune response expedites COVID-19 recovery

Researchers examine the role of inflammatory mediator expression networks on clinical outcomes in individuals with high/low SARS-CoV-2 burden.

20 Mar 2023

Poor inflammatory immune response in obese patients increases susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

20 Mar 2023

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Researchers provide evidence that a novel vaccine candidate robustly neutralized SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB.

16 Mar 2023

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Researchers assessed the association between SARS-CoV-2 infection and DNA damage and cellular senescence.

14 Mar 2023

Hyperinflammation triggers long COVID headaches

Researchers characterize the immunological and metabolic alterations involved in chronic headache onset during post-acute sequelae of COVID-19.

13 Mar 2023

How does temperature affect host responses to SARS-CoV-2 and IAV infection in human nasal epithelial cells?

A new preprint examines the response to these pathogens in the nose, which is the primary portal of entry for both.

13 Mar 2023

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Researchers observe persistent SARS-CoV-2 replication in severe COVID-19 patient lungs.

13 Mar 2023

Important backup mechanism of human immune cells elucidated

The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses.

10 Mar 2023

Investigating the impact of COVID-19 vaccinations in immunocompromised adult patients

In a recent study posted to the medRxiv* preprint server, researchers assessed the impact of third and fourth coronavirus disease 2019 (COVID-19) vaccination doses on immunity against COVID-19 among immunocompromised adult patients.

9 Mar 2023

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Researchers identified that individuals with a deficiency of myeloid differentiation primary response 88 (MyD88) and interleukin-1 receptor-associated kinase 4 (IRAK-4) due to an autosomal recessive condition were highly susceptible to developing hypoxemic coronavirus disease 2019 (COVID-19) pneumonia when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

9 Mar 2023

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

Researchers assessed the impact of an anti-CD3 monoclonal antibody called Foralumab in COVID-19 treatment.

9 Mar 2023

C-reactive protein has a beneficial function in systemic lupus erythematosus

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers at Linköping University in Sweden now show that this protein has a beneficial function in systemic lupus erythematosus, SLE, an inflammatory disease.

9 Mar 2023

Connection between mitochondrial metabolite and activation of inflammatory response revealed

A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response.

8 Mar 2023

Interferon autoantibodies not implicated in long-COVID

Researchers assess the proportion of interferon autoantibodies in long COVID patients.

6 Mar 2023

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Researchers examined the vaccination effects and local antigen expression efficiency of a needle-free vaccination technique involving pyro-drive liquid jet injection (PYRO) to deliver the naked messenger ribonucleic acid (mRNA) to the skin.

3 Mar 2023

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Researchers performed multi-organ single-cell RNA sequencing of collagen-induced arthritis murine model to evaluate immune-mediated inflammatory disease alterations by characterizing the genome, organizing the organome, and prioritizing pathways in the multi-organ data.

3 Mar 2023

Interferon News and Research

SARS-CoV-2 infection enhances vaccine-induced immunological memory against spike protein

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

Childhood common colds help protect against COVID-19

Real-world studies show efficacy, safety of BLV monotherapy in patients with HDV-related compensated cirrhosis

Elevated mucosal immune response expedites COVID-19 recovery

Poor inflammatory immune response in obese patients increases susceptibility to severe COVID-19

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Hyperinflammation triggers long COVID headaches

How does temperature affect host responses to SARS-CoV-2 and IAV infection in human nasal epithelial cells?

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Important backup mechanism of human immune cells elucidated

Investigating the impact of COVID-19 vaccinations in immunocompromised adult patients

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

C-reactive protein has a beneficial function in systemic lupus erythematosus

Connection between mitochondrial metabolite and activation of inflammatory response revealed

Interferon autoantibodies not implicated in long-COVID

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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