Interferon News and Research

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Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Researchers examine the mechanisms responsible for the increased risk of neurocognitive impairment in HIV patients and explore potential treatments.

12 Oct 2023

Immature immune cells near dural sinuses linked to neonatal viral meningoencephalitis

Examine virus propagation within central nervous systems (CNSs) during systemic infection.

9 Oct 2023

Is there an association between psoriasis onset and risk of autoimmune disease?

Researchers evaluated new-onset autoimmune disease risk among individuals with new-onset psoriatic illness.

9 Oct 2023

New animal model replicates the development of cardiac sarcoidosis

Sarcoidosis is an inflammatory disease in which immune cells form tissue nodules in various organs, which can drastically impair organ function.

5 Oct 2023

Unveiling the role of astrocyte-derived LCN2 in neurodegenerative disease progression

Researchers reviewed existing data on the neurodegenerative effects of astrocyte-derived lipocalin-2 (LCN-2).

4 Oct 2023

New study reveals alarming cardiovascular risks from COVID

The study published in Nature Cardiovascular Research reveals that SARS-CoV-2, the virus causing COVID-19, can directly infect coronary vessels and arterial plaques, heightening the risk of cardiovascular complications like heart attacks and strokes. These findings offer critical insights into the increased long-term cardiovascular risks for COVID-19 survivors and open new avenues for targeted therapies.

1 Oct 2023

Examining the cardiac pathology in fatal cases of yellow fever

The characteristics of yellow fever (YF)-related myocardial damage.

28 Sep 2023

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

New study in Nature Medicine links yeast cells in the gastrointestinal tract to abnormal immune responses causing inflammation in Crohn's disease patients. The research suggests that these yeast-reactive T-cells could be a potential therapeutic target, offering new avenues for treatment.

27 Sep 2023

Mutations on a key SARS-CoV-2 viral protein linked to extreme immune responses

Mutations on a key SARS-CoV-2 viral protein are linked to extreme immune responses and could offer a novel vaccine target.

27 Sep 2023

How are SARS-CoV-2 variants outsmarting our immune system and vaccines?

Researchers use multiomics analysis to understand how SARS-CoV-2 variants, including Alpha, Delta, and Omicron, modulate the host's cellular responses and adapt to evade human immunity. The study highlights the potential for targeted therapies against both adaptive and innate immune responses.

25 Sep 2023

Tufts Lyme Disease Initiative receives $7M in grants to advance research to next level

Researchers at the Tufts Lyme Disease Initiative recently received grants totaling more than $7 million to build on an already impressive array of discoveries that Tufts' teams have made to combat tick-borne diseases.

19 Sep 2023

Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

A recent review in the journal Immunity delves into the crucial role of dendritic cells (DCs) in shaping T-cell responses in cancer, highlighting their importance in both priming anti-tumor immunity and in ongoing immune interactions within tumors. The findings underscore the potential of DCs as key targets for next-generation cancer immunotherapies.

18 Sep 2023

Past infections may shape your COVID booster's punch against Omicron

This in-depth study examines how previous immunity impacts the effectiveness of COVID-19 booster vaccinations and susceptibility to Omicron breakthrough infections. The research highlights the significant role of individual immune histories in shaping both humoral and cellular responses to SARS-CoV-2, urging for more tailored vaccine strategies.

14 Sep 2023

Interferon-gamma essential for lung-resident memory B cell development after influenza infection

During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body.

13 Sep 2023

Psoriasis vs. atopic dermatitis: New study reveals surprising inflammatory differences in age-specific groups

The hematological parameters and serum biomarkers of inflammation and immunity in patients with atopic dermatitis and psoriasis.

12 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

Researchers conducted the phase 1 trial of orally-administered senolytic therapy comprising quercetin (Q) and dasatinib (D) for symptomatic and early-stage Alzheimer's disease (AD) patients.

8 Sep 2023

Chronic inflammation's influence on TP53 mutations in leukemia evolution explored in new study

Researchers performed a multi-omics evaluation of HSPCs obtained from individuals with myeloproliferative neoplasms transforming to TP53-related secondary forms of acute myeloid leukemia.

7 Sep 2023

Early viral exposure in mice weakens vaccine response, raising questions for human studies

Researchers at Washington University have demonstrated that early life exposure to multiple viruses in house mice dampens the immune response to SARS-CoV-2 vaccinations later in life. The study raises concerns about the applicability of common mouse models in immunological research, suggesting that prior pathogen exposure could be a significant variable in predicting vaccine efficacy.

5 Sep 2023

How SARS-CoV-2 hijacks Fragile X proteins to fuel infection: New clues in COVID-19 and genetic disorders

Study explores the interaction between SARS-CoV-2's non-structural protein 3 (NSP3) and proteins related to Fragile X mental retardation (FMRPs), shedding light on COVID-19 pathophysiology. The research suggests that the virus exploits these host cell proteins for effective infection and possibly interferes with antiviral defense mechanisms, offering new insights into the genetic basis of Fragile X syndrome.