Interferons News and Research

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Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

German researchers have found a significant association of IL28B genotypes to interferon-based antiviral treatment outcome, and to graft inflammation caused by hepatitis C virus (HCV). The study determined that the presence of G-allele serves as a marker for severe HCV-induced graft inflammation, as well as a predictor for unsuccessful treatment. Study findings—the largest to report on the role IL28B variants in a transplant cohort with recurrent HCV—are published in the March issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases.

2 Mar 2011

Cancer drug may help combat flu

Ever get a flu shot and still get the flu? If so, there's new hope for flu-free winters in the years to come thanks to a new discovery by researchers who found that a drug called DMXAA, originally developed as anti-tumor agent, enhances the ability of flu vaccines to ward off this deadly virus.

1 Mar 2011

Immune protein exacerbates skin cancer due to sun exposure: Study

An unexpected immune protein exacerbates cancer due to sun exposure, report researchers in the January 27th issue of Nature. The study suggests that drugs blocking the protein might halt tumor growth in skin cancer patients.

3 Feb 2011

Idera reports positive data from IMO-2125/ribavirin combination Phase 1 trial in null-responder HCV patients

Idera Pharmaceuticals, Inc. announced today preliminary data from a 4-week dose-ranging Phase 1 clinical trial of IMO-2125 in combination with ribavirin in 60 treatment-naïve patients with genotype 1 chronic hepatitis C virus (HCV) infection. In the trial, treatment with IMO-2125 in combination with ribavirin was well tolerated and achieved substantial decline in virus levels at two days after the first dose of IMO-2125 and after four weeks of treatment.

20 Dec 2010

Scientists solve structure of key protein from Lassa virus

Scientists at Emory University and the University of St. Andrews have solved the structure of a key protein from Lassa virus, which is endemic to West Africa and can cause a deadly hemorrhagic fever.

18 Nov 2010

Clinical trial shows dalfampridine tablets improve walking ability in MS patients

Acorda Therapeutics, Inc. today announced that data from the second of two pivotal dalfampridine extended release tablets Phase 3 clinical trials in multiple sclerosis (MS) were published in the October 2010 edition of Annals of Neurology.

18 Nov 2010

Viruses lead to discovery of security system in host cells

Viruses have led scientists at Washington University School of Medicine in St. Louis to the discovery of a security system in host cells.

18 Nov 2010

Idera presents IMO-2125 Phase 1 clinical trial data for HCV infection at AASLD Meeting

Idera Pharmaceuticals, Inc. announced today the presentation of data from a Phase 1 clinical trial evaluating IMO-2125, a novel immune modulator, in null-responder patients with chronic hepatitis C virus (HCV) infection.

1 Nov 2010

Myrexis to present MPI-0485520 preclinical data at Annual Scientific Meeting

Myrexis, Inc., a biotechnology company focused on discovering, developing, and commercializing novel treatments for cancer, today announced it will present a poster at the 74th Annual Scientific Meeting of the American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP), to be held November 7-11, 2010 in Atlanta, Georgia.

7 Oct 2010

Humans have similar immune system like plants

In addition to known antiviral agents such as antibodies and interferons, people also seem to have a similar immune system to that previously identified in plants. This is the result of research carried out by Esther Schnettler at Wageningen University.

28 Sep 2010

Researchers identify interferons may inhibit IL-1b protein production

Among the first is the production of cell factors such as interferons and IL-1beta. Interferons have several functions, including activating a series of intracellular signals such as Tyk2 (Tyrosine kinase 2), while IL-1beta is important for the induction of inflammation, which helps directly to protect the body against attack.

16 Sep 2010

ZymoGenetics completes enrollment in Phase 2b PEG-IFN lambda clinical trial

ZymoGenetics, Inc. today announced enrollment has been completed in the Phase 2b clinical trial with PEG-Interferon lambda and ribavirin in chronic hepatitis C virus (HCV) infection.

25 Aug 2010

TLR7, TLR9 proteins could be culprit behind lupus patients' resistance to steroid treatments: Scientists

Two immune system proteins could be the culprit behind many lupus patients' resistance to widely used steroid treatments, scientists with the Baylor Research Institute in Dallas announced today. It is estimated that more than 5 million people suffer from lupus worldwide.

13 Jul 2010

Treatment options for patients with MS

The best one-word description for multiple sclerosis is "unpredictable," according to the June issue of Mayo Clinic Women's HealthSource. MS interferes with the communication between the brain and the rest of the body. Just how that interference plays out in symptoms is different for everyone -- thus, the unpredictable label.

24 Jun 2010

Biogen Idec initiates enrollment in Phase II BG-12 combination trial for relapsing-remitting multiple sclerosis

Biogen Idec today announced enrollment of the first patient in a multicenter Phase II clinical trial designed to evaluate its investigational oral therapy BG-12 (dimethyl fumarate) in combination with commonly used first-line treatments in patients with relapsing-remitting multiple sclerosis (RRMS).

15 Jun 2010

Researchers determine critical role of bone marrow cells in fighting respiratory viruses

Researchers at Mount Sinai School of Medicine for the first time have determined that bone marrow cells play a critical role in fighting respiratory viruses, making the bone marrow a potential therapeutic target, especially in people with compromised immune systems. They have found that during infections of the respiratory tract, cells produced by the bone marrow are instructed by proteins to migrate to the lungs to help fight infection. The data are published in the current issue of Cell Host & Microbe.

25 May 2010

Joint research by UB and CDC could lead to new generation of antiviral medicines

Future pandemics of seasonal flu, H1N1 and other drug-resistant viruses may be thwarted by a potent, immune-boosting payload that is effectively delivered to cells by gold nanorods, report scientists at the University at Buffalo and the U.S. Centers for Disease Control and Prevention. The work is published in the current issue of the Proceedings of the National Academy of Sciences.

25 May 2010

Scientists discover prothymosin-alpha protein to control HIV and other infections

Scientists at Duke University Medical School and Mount Sinai School of Medicine have found a new role for a host protein that provides further insight into how CD8+ T cells work to control HIV and other infections. Study authors say the finding may yield new strategies for prevention or treatment.

18 May 2010

Clinical trial data on AMPYRA Extended Release Tablets to be presented at AAN Annual meeting

Acorda Therapeutics, Inc. today announced that four new analyses of clinical trial data on AMPYRA™ (dalfampridine) Extended Release Tablets 10 mg are being presented at the 62nd American Academy of Neurology Annual meeting.

13 Apr 2010

Messenger substance plays significant role in viral diseases and reactions to infections

The connection with the blood circulatory system is a significant step in the development of cancer. Within the tissue where it is growing, the tumour develops an independent existence. With signal substances it entices white blood cells from the bone marrow into the tumour tissue.

6 Apr 2010

Interferons News and Research

Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

Cancer drug may help combat flu

Immune protein exacerbates skin cancer due to sun exposure: Study

Idera reports positive data from IMO-2125/ribavirin combination Phase 1 trial in null-responder HCV patients

Scientists solve structure of key protein from Lassa virus

Clinical trial shows dalfampridine tablets improve walking ability in MS patients

Viruses lead to discovery of security system in host cells

Idera presents IMO-2125 Phase 1 clinical trial data for HCV infection at AASLD Meeting

Myrexis to present MPI-0485520 preclinical data at Annual Scientific Meeting

Humans have similar immune system like plants

Researchers identify interferons may inhibit IL-1b protein production

ZymoGenetics completes enrollment in Phase 2b PEG-IFN lambda clinical trial

TLR7, TLR9 proteins could be culprit behind lupus patients' resistance to steroid treatments: Scientists

Treatment options for patients with MS

Biogen Idec initiates enrollment in Phase II BG-12 combination trial for relapsing-remitting multiple sclerosis

Researchers determine critical role of bone marrow cells in fighting respiratory viruses

Joint research by UB and CDC could lead to new generation of antiviral medicines

Scientists discover prothymosin-alpha protein to control HIV and other infections

Clinical trial data on AMPYRA Extended Release Tablets to be presented at AAN Annual meeting

Messenger substance plays significant role in viral diseases and reactions to infections

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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