Myrexis to present MPI-0485520 preclinical data at Annual Scientific Meeting

Oct 7 2010

Myrexis, Inc. (Nasdaq:MYRX), a biotechnology company focused on discovering, developing, and commercializing novel treatments for cancer, today announced it will present a poster at the 74th Annual Scientific Meeting of the American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP), to be held November 7-11, 2010 in Atlanta, Georgia.

Data will be presented on MPI-0485520, a potent and selective oral anti-interferon (OAI) in preclinical development. MPI-0485520 targets I kappa B kinase epsilon (IKK epsilon) and TANK-binding kinase 1 (TBK1), which are required for the initiation of certain inflammatory immune responses involving type-I interferons (IFN alpha/beta).

Preclinical studies of MPI-0485520 have demonstrated potent and selective suppression of IFN alpha/beta and other pro-inflammatory cytokines involved in autoimmune disorders such as systemic lupus erythematosus. The compound also exhibits high oral bioavailability and a favorable ADME/PK profile. Additionally, recent publications have identified IKK epsilon as a promising and novel therapeutic target for the treatment of rheumatoid arthritis.