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Machine learning uncovers promising drug leads against human enterovirus 71

Artificial intelligence algorithms have now been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease.

29 Apr 2025

Why different loneliness tests still identify the same emotional struggles

Researchers examined how loneliness classifications, by frequency, distress, or chronicity, relate to cognitive and behavioral traits in 790 adults. Despite modest agreement between classification methods, the study found consistent psychological patterns among lonely individuals across all types of loneliness.

29 Apr 2025

Measles makes a deadly comeback in Europe as vaccine gaps widen

In 2024, measles cases in Europe soared to the highest levels in decades, with over 35,000 reported cases, 87% from Romania alone. Most affected were unvaccinated children, revealing critical immunity gaps and suboptimal vaccination coverage across the EU/EEA.

29 Apr 2025

Gut bacteria and metabolites reveal depression-linked patterns in older adults

A cross-sectional study of 400 older adults with metabolic syndrome reveals that individuals with depression have distinct gut microbiota and metabolite profiles. Eight bacterial genera and 15 fecal metabolites were significantly associated with depression, suggesting a gut-brain axis link.

29 Apr 2025

Nectin4-targeted VHH-CAR-T cells show potency against bladder cancer

Announcing a new article publication for BIO Integration journal. Bladder cancer (BLCA) is one of the most common malignancies and the second most frequent urogenital tract tumor.

29 Apr 2025

Genetic predisposition to muscle strength linked to lower cardiovascular mortality

A study conducted by the Faculty of Sport and Health Sciences at the University of Jyväskylä, Finland, found that men with a genetic predisposition supporting higher muscle strength had a lower risk of dying from cardiovascular diseases, regardless of their leisure-time physical activity levels or other lifestyle-related factors.

29 Apr 2025

New compounds identified as inhibitors of DNA topoisomerase 1

Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at the University of Seville in CABIMER) and with PharmaMAR, has identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA.

29 Apr 2025

Intimate relationships may shield against cognitive decline during chemo

A satisfying intimate relationship may help diminish chemotherapy-related cognitive problems experienced by patients with breast cancer, a new study suggests.

29 Apr 2025

Researchers uncover how substance use accelerates brain aging

In a comprehensive Genomic Press Interview, researchers from UTHealth Houston have uncovered crucial evidence that substance use disorders (SUDs) accelerate biological aging in the brain through distinct molecular mechanisms.

29 Apr 2025

Synthetic tau protein reveals key insights into protein misfolding and fibril formation

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion.

29 Apr 2025

Researchers discover new biomarker to predict multiple sclerosis progression

Researchers at the University of Turku, Finland, have discovered a new biomarker that can predict the progression of multiple sclerosis (MS).

29 Apr 2025

How blood iron levels shape the pace of biological aging

Researchers examine the role of blood iron levels in DNA methylation-based measurements of biological aging.

29 Apr 2025

Hormone therapy boosts heart health markers but raises some risks

Researchers assess hormone therapy-induced changes in cardiovascular biomarkers.

29 Apr 2025

Pecans lower cholesterol and improve diet quality in at-risk adults, study finds

Substituting 57 grams of pecans for usual snacks over 12 weeks improved lipid profiles and diet quality but did not affect vascular function in adults at cardiometabolic risk. A modest weight gain was also observed.

29 Apr 2025

Routine molecular monitoring doubles survival in high-risk AML subtypes

A highly sensitive bone marrow test could double survival rates for some groups of younger adults with Acute Myeloid Leukemia (AML) by helping doctors identify if they might relapse up to three months earlier.

29 Apr 2025

Noninvasive brain modulation using sound waves shows promise for depression and anxiety

Patients suffering from depression, anxiety and trauma-related disorders experienced significant relief from their symptoms after a new treatment that uses sound waves to modulate deep brain activity, according to new research from Dell Medical School at The University of Texas at Austin.

28 Apr 2025

Obesity changes how the gut responds to plant compounds, researchers report

Researchers found that the impact of polyphenols rutin and genistein on the human fecal metabolome varies significantly by body mass index (BMI). Lower BMI individuals showed more diverse metabolic responses, revealing how gut health and obesity could shape polyphenol metabolism.

28 Apr 2025