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Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Researchers created xenocortical mice by transplanting human cortical organoids into animals genetically depleted of much of their native cortex, allowing the human tissue to occupy most of the available cortical space and form anatomical connections throughout the host nervous system. The grafts developed diverse cortical cell types, including L5-ET and VEN-like neurons, generated organized neural activity, and produced measurable cellular and behavioral responses to hypoxic injury.

18 Sep 2026

Diaceutics launches Precision for All Strategic Collaboration at Fierce Pharma Week 2026

Intelligence and engagement company, Diaceutics, is bringing together senior voices from across the biopharmaceutical industry at the Precision for All Strategic Collaboration, launching at Fierce Pharma Week 2026.

From Diaceutics PLC 18 Sep 2026

Some food manufacturers could capture major nutrition and environmental gains by changing surprisingly few products

Researchers assessed the nutritional quality and environmental impacts of product portfolios from 44 major UK food and beverage manufacturers, covering 51.5% of the retail market. Their modelling showed that targeted changes to existing product lines could capture a substantial share of the potential nutrition and environmental gains for some manufacturers, although broader food-system changes would still be required to meet national and societal targets.

18 Sep 2026

Better fitness was linked to healthier brain structure, but not better memory

Researchers studying 353 cognitively unimpaired adults aged 60 to 94 found that higher muscular capacity was associated with lower basal ganglia perivascular space volume, while greater aerobic fitness was associated with greater gray matter volume and medial temporal lobe thickness. Fitness was not directly associated with global cognition or episodic memory, and evidence for cognitive reserve was limited, although VO₂max explained additional variation in delayed verbal memory beyond tau burden.

18 Sep 2026

Sex-specific biological clocks reveal how aging differs across the body in women and men

Researchers developed 38 sex-specific biological aging clocks across 15 organ systems, finding differences between females and males in genetic architecture, molecular signatures, disease associations, and mortality patterns. Brain aging clocks were linked to progression from mild cognitive impairment to Alzheimer’s disease in both sexes and to sex-dependent cognitive trajectories among solanezumab-treated A4 participants, while the authors stressed that sex-pooled and sex-interaction models remain complementary approaches.

17 Sep 2026

Researchers mine cobra toxins to uncover a membrane-disrupting antimicrobial peptide

Researchers combined toxin sequence mining with machine learning and deep-learning prediction tools to identify and experimentally test 14 antimicrobial peptide candidates derived from cobra cardiotoxins. Most candidates showed limited antibacterial potency, while CTX-p5 displayed moderate membrane-disrupting activity, revealing both the potential and current limitations of computationally guided venom peptide discovery.

17 Sep 2026

Scientists reveals how cancer-causing p53 mutations remain invisible to the immune system

One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see.

17 Sep 2026

Celastrol reduces cholestatic liver injury by inhibiting specific protein

Cholestasis occurs when bile formation, secretion, or flow is impaired, causing toxic bile acids to accumulate and trigger inflammation and liver-cell damage.

17 Sep 2026

Immunotherapy combined with BCG vaccine drastically lowers tuberculosis relapse risk

Tuberculosis (TB) remains one of the world's leading causes of death, and preventing post-treatment relapse continues to be a major worldwide health challenge.

17 Sep 2026

Deafness prompts brain rewiring to enhance peripheral vision

The brains of people who are deaf from an early age re-wire to see more of what is happening in their visual periphery, new research has revealed.

17 Sep 2026

New clinical guidelines standardize kidney replacement therapy in ICU patients

Acute kidney injury (AKI) is a common and severe complication in the intensive care unit (ICU). Due to its high incidence, strong correlation with poor prognosis, and substantial consumption of medical resources, AKI has become one of the central challenges in modern critical care medicine.

17 Sep 2026

New indicators could accelerate development of anti-aging drugs

Twelve candidate indicators, based on studies in mice, could make developing anti-aging interventions faster-while offering new insights into age-related diseases.

17 Sep 2026

Study identifies bile acid that helps reduce excess fat accumulation in the liver

Non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is a common condition that causes excess fat to build up in the liver, affecting about one-quarter of adults worldwide.

17 Sep 2026

Groundbreaking technology uses quantum sensors to measure heart activity

Physicists at Johannes Gutenberg University Mainz (JGU) have developed a groundbreaking technology that uses quantum sensors to measure biomagnetic signals, such as heart activity.

17 Sep 2026

Innate immune system variations determine vaccine side effects

Redness and pain at the injection site, fever, fatigue or headaches: vaccines can cause side effects, but their frequency and severity vary considerably from person to person.

17 Sep 2026

Scalable machine learning model maps complex genomic enhancers across tissues

Understanding gene regulation may be the key to interpreting human disease genetics. Genes are regulated in part by stretches of DNA called enhancers, which define when, where, and how strongly each gene is turned on.

17 Sep 2026

SARS-CoV-2 uses two fusion keys to enter host cells

To enter our cells, the Covid-19 virus fuses its surrounding membrane with the membrane of the target cell.

17 Sep 2026

Salk scientists demonstrate B cells directly enhance killer T cell function

Cancer is the second leading cause of death in the United States, according to a 2026 Cancer Research Institute report. Cancer biologists are keenly aware of this statistic, as it drives them to innovations that revolutionize cancer care-innovations like immunotherapy.

17 Sep 2026

Some mice showed signs of stress resilience before the stress even began

Researchers found that mice later classified as resilient showed stronger coordination between neuronal OFF-periods and slow-wave activity in the prelimbic cortex even before social stress. After social defeat, resilient mice also showed a distinct reorganization of neuronal silence during NREM sleep, linking local sleep dynamics with behavioral resilience.

17 Sep 2026

New MRI measure maps blood flow and cellular organization

Researchers from the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have developed a new, noninvasive way to examine how blood flow and cellular organization align across the layers of the living human brain.

17 Sep 2026

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Medical Science News

Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Diaceutics launches Precision for All Strategic Collaboration at Fierce Pharma Week 2026

Some food manufacturers could capture major nutrition and environmental gains by changing surprisingly few products

Better fitness was linked to healthier brain structure, but not better memory

Sex-specific biological clocks reveal how aging differs across the body in women and men

Researchers mine cobra toxins to uncover a membrane-disrupting antimicrobial peptide

Scientists reveals how cancer-causing p53 mutations remain invisible to the immune system

Celastrol reduces cholestatic liver injury by inhibiting specific protein

Immunotherapy combined with BCG vaccine drastically lowers tuberculosis relapse risk

Deafness prompts brain rewiring to enhance peripheral vision

New clinical guidelines standardize kidney replacement therapy in ICU patients

New indicators could accelerate development of anti-aging drugs

Study identifies bile acid that helps reduce excess fat accumulation in the liver

Groundbreaking technology uses quantum sensors to measure heart activity

Innate immune system variations determine vaccine side effects

Scalable machine learning model maps complex genomic enhancers across tissues

SARS-CoV-2 uses two fusion keys to enter host cells

Salk scientists demonstrate B cells directly enhance killer T cell function

Some mice showed signs of stress resilience before the stress even began

New MRI measure maps blood flow and cellular organization

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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