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Review highlights TIGIT as a promising second-generation immunotherapy target

Malignant tumors remain a major threat to human health, with conventional therapies and first-generation immune checkpoint inhibitors (ICIs) facing limitations like drug resistance and low response rates.

5 Jun 2026

Antibody fragment offers safer alternative for Alzheimer disease treatment

In 2025, the European Medicines Agency approved two antibodies for Alzheimer's disease: lecanemab (Leqembi, from Biogen) and donanemab (KisunlaTM, from Eli Lilly and Company), both based on immunotherapy (the use of molecules from the immune system to treat diseases).

5 Jun 2026

Untargeted metabolomics approach identifies potential biomarkers for latent tuberculosis diagnosis

Announcing a new article publication in BIO Integration. Latent tuberculosis infection (LTBI) is difficult to diagnose due to the lack of a definitive gold standard.

5 Jun 2026

What older adults eat may shape dementia risk

Higher ultraprocessed food intake was associated with increased risks of dementia, cognitive impairment with no dementia, and the combined outcome among older US adults in the Health and Retirement Study. Minimally processed food intake showed the opposite pattern, although the observational findings require cautious interpretation because diet was self-reported and cognitive outcomes were not clinically diagnosed.

4 Jun 2026

Blood protein signature can predict lung cancer risk before diagnosis

Researchers at the Francis Crick Institute and University College London (UCL), funded by Cancer Research UK and the European Research Council (ERC), have identified a 14-protein signature in the blood that can predict lung cancer risk more than five years before diagnosis.

4 Jun 2026

Microglia transitions act as critical turning point in Alzheimer's

Researchers from VIB, KU Leuven, the UK-DRI and Muna Therapeutics, funded by, among others, ERC, have uncovered a critical biological transition that may determine whether Alzheimer's disease pathology leads to dementia.

4 Jun 2026

Study reveals how breast cancer cells hide in the bone marrow

Treating breast cancer remains a major medical challenge worldwide. This is largely due to the ability of breast cancer cells to remain hidden for years before triggering a relapse, which can occur even decades after successful treatment of the primary tumor.

4 Jun 2026

New topical gel uses repurposed MS drug to heal burns

Researchers at the Terasaki Institute for Biomedical Innovation and the University of Arizona College of Medicine have developed a topical gel formulation with 4-aminopyridine (4-AP), to treat burn wounds, achieving near-complete closure in 21 days.

4 Jun 2026

Study reveals the first direct saliva biomarkers of sleep loss

Sleep loss dulls alertness and coordination, and it can produce effects similar to severe intoxication, making actions like driving incredibly risky. But there's no clinical test for determining when someone is dangerously sleep deprived.

4 Jun 2026

CIC biomaGUNE develops pulmonary surfactant nanoparticles to treat lung diseases

The CIC biomaGUNE Center for Cooperative Research in Biomaterials has developed pulmonary surfactant nanoparticles (the blend of lipids and proteins that lines the alveoli and enables breathing), which are encapsulated in a drug used to treat pulmonary fibrosis.

4 Jun 2026

Brain remodeling bypasses the prefrontal bottleneck to automate complex skills

New research by Georgetown scientists shows how the brain rewires itself to automate learned tasks. The findings challenge a long-held understanding of how humans master complex skills, suggesting that true multitasking is really possible.

4 Jun 2026

Real-world study exposes suboptimal adherence to treat-to-target rheumatic strategies

EULAR - The European Alliance of Associations for Rheumatology - acknowledges the role of diverse real-world data to complement knowledge from randomized controlled trials.

4 Jun 2026

Researchers discover a biological barrier that limits mucosal vaccine immunity

A consistent biological barrier that stops the immune system from making the antibodies most needed to protect the nose and throat from respiratory viruses has been identified.

4 Jun 2026

Novel CAR T treatment makes previously impossible kidney transplants possible

A pioneering clinical trial has successfully enabled two patients with end-stage kidney disease to receive previously improbable kidney transplants.

3 Jun 2026

Long-term exposure to air pollution associated with lower semantic memory

A new study by researchers at UC Davis Health and Kaiser Permanente found that higher exposure to very small air pollution particles (PM2.5) over a 17-year span was associated with lower semantic memory.

3 Jun 2026

Study potentially opens a new route to more selective cancer drug design

Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward the development of a new generation of more precise cancer drugs.

3 Jun 2026

New manufacturing platform produces targeted mixtures of beneficial gut bacteria

Researchers at the Icahn School of Medicine at Mount Sinai have developed a new manufacturing platform for producing targeted mixtures of beneficial gut bacteria, an approach that could help expand access to microbiome-based therapies for patients with recurrent Clostridioides difficile (C. difficile) infection.

3 Jun 2026