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Vulnerable DNA sites make cancer cells sensitive to PARP inhibitors

A small subset of vulnerable DNA sites can make cancer cells highly sensitive to targeted drugs called PARP inhibitors, a new study shows.

5 Nov 2026

Compound YZG-331 leverages gut microbiota to improve sleep in mouse models of insomnia

This new article publication from Acta Pharmaceutica Sinica B discusses how interactions between the investigational compound YZG-331 and the gut microbiota contribute to its sleep-promoting effects in mouse models of insomnia.

5 Nov 2026

Anti-PEG antibodies drive contrasting liposome skin toxicity across species

This new article publication from Acta Pharmaceutica Sinica B discusses how anti-polyethylene glycol antibodies affect the movement of stealth liposomes from blood into skin, revealing contrasting distribution and toxicity patterns in mice and rats.

5 Nov 2026

Pattern-based patient selection associated with positive clinical trial results

This new article publication from Acta Pharmaceutica Sinica B discusses the association between using traditional Chinese medicine patterns to select participants and statistically significant primary outcomes in randomized placebo-controlled trials of Chinese herbal formulas.

5 Nov 2026

New covalent inhibitor targets DNAJC9 to reduce sepsis inflammation

This new article publication from Acta Pharmaceutica Sinica B discusses the discovery of the covalent inhibitor A12 and the identification of DNAJC9 as a potential drug target for sepsis-associated inflammation.

5 Nov 2026

Innovative framework advances EEG-based emotion recognition

Emotion recognition plays an important role in understanding human cognition and behavior, and has potential applications in brain-computer interfaces and mental health monitoring.

5 Nov 2026

Topadur’s Phase 2a trial of TOP-N53 for systemic sclerosis-associated digital ulcers advances to next dose levels

Topadur Pharma AG, a Swiss clinical-stage biopharmaceutical company, today announced that the Safety Review Committee of its Phase 2a trial has recommended progression to the next planned dose levels.

5 Nov 2026

Elusive HIV strains cause breakthrough infections after antibody treatment ends

The broadly neutralizing antibody VRC01 has been thoroughly vetted as a potential prophylactic that could prevent people from becoming infected with HIV.

5 Nov 2026

Scientists develop slug-inspired hydrogel to seal gastrointestinal fistulas

Gastrointestinal fistulas are abnormal passages between the digestive tract and another organ or tissue. They are a common complication of surgery, trauma, inflammatory diseases, and malignant tumors and can be life-threatening in severe cases.

5 Nov 2026

Engineered IL-39 cytokine unlocks new pathways for immunotherapy

In a new preclinical study, scientists present a molecular engineering approach to modify and repurpose a cytokine named IL-39, which plays a central role in inflammation and immunity.

5 Nov 2026

Graded physical activity prescriptions improve functional outcomes in psychiatry

Most of us have heard the advice so often that it has worn smooth, like a stone in a river: get some exercise. A new peer-reviewed Viewpoint in Brain Health, drawing on randomized trials, meta-analyses, and cohort studies, argues that this familiar sentence has been doing the wrong job.

5 Nov 2026

Organoid coculture platforms enhance preclinical prediction of drug efficacy

Three‐dimensional cancer organoids cultured in vitro closely recapitulate the phenotypic and genetic features of parental tumor tissues, making them powerful tools for cancer research, drug screening, and personalized medicine.

5 Nov 2026

Targeting brain protein may help treat MEF2C-related neurological disorders

A particular signaling protein in the brain could be a therapeutic target for neurological disorders arising from the deletion of the autism-linked gene MEF2C, University of Illinois Urbana-Champaign researchers found in a new mouse study.

4 Nov 2026

Longer reproductive lifespan and hormonal history may influence brain vascular health

A longer reproductive lifespan and a history of using birth control pills or menopausal hormone therapy were associated with certain signs of blood vessel health in the brain, according to a study published November 4, 2026, in Neurology, the medical journal of the American Academy of Neurology.

4 Nov 2026

Psychedelics linked to lingering visual disturbances resembling early psychosis

Every night, as he fell asleep, a 25-year-old man saw an eye in his ceiling. It was huge and unblinking, and it felt as if the whole world was being sucked into it.

4 Nov 2026

Rutgers specialist launches awareness initiative for often-misdiagnosed tailbone pain

Thousands of people suffer with tailbone pain, often struggling to find an accurate diagnosis and effective treatment.

4 Nov 2026

Modern lifestyles may be changing our gut bacteria in unexpected ways

A global study of 1,015 adults across 12 countries found that industrialized lifestyles were associated with lower gut bacterial diversity, reduced microbial community stability, and increased markers of intestinal stress and immune activity. The researchers also found that a microbiome-based health index developed using industrialized populations performed poorly in less-industrialized communities, raising concerns about its applicability across diverse populations.

4 Nov 2026

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed mechanisms and therapeutic implications require further investigation.

4 Nov 2026

New nanovesicle therapy shows promise for treating alcohol-related liver disease

Alcohol-related liver disease (ALD) is characterized by hepatocellular injury, oxidative stress, inflammation, and extracellular matrix remodeling, yet effective therapies remain limited.

4 Nov 2026

New method detects lung antibodies through non-invasive exhaled breath

For the first time, researchers have succesfully measured antibodies against specific respiratory viruses in exhaled air. This is shown in a new study involving, amongst others, the Karolinska Institutet, published in eBioMedicine.

4 Nov 2026

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Medical Science News

Vulnerable DNA sites make cancer cells sensitive to PARP inhibitors

Compound YZG-331 leverages gut microbiota to improve sleep in mouse models of insomnia

Anti-PEG antibodies drive contrasting liposome skin toxicity across species

Pattern-based patient selection associated with positive clinical trial results

New covalent inhibitor targets DNAJC9 to reduce sepsis inflammation

Innovative framework advances EEG-based emotion recognition

Topadur’s Phase 2a trial of TOP-N53 for systemic sclerosis-associated digital ulcers advances to next dose levels

Elusive HIV strains cause breakthrough infections after antibody treatment ends

Scientists develop slug-inspired hydrogel to seal gastrointestinal fistulas

Engineered IL-39 cytokine unlocks new pathways for immunotherapy

Graded physical activity prescriptions improve functional outcomes in psychiatry

Organoid coculture platforms enhance preclinical prediction of drug efficacy

Targeting brain protein may help treat MEF2C-related neurological disorders

Longer reproductive lifespan and hormonal history may influence brain vascular health

Psychedelics linked to lingering visual disturbances resembling early psychosis

Rutgers specialist launches awareness initiative for often-misdiagnosed tailbone pain

Modern lifestyles may be changing our gut bacteria in unexpected ways

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

New nanovesicle therapy shows promise for treating alcohol-related liver disease

New method detects lung antibodies through non-invasive exhaled breath

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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