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Epigenetic drugs improve blood vessel health in obesity and diabetes

People with obesity and type 2 diabetes are at high risk of blood vessel damage. This risk depends not only on the genes a person carries, but also on how they are "read".

18 Jun 2026

New biological age tools could reveal health risks before symptoms appear

A JCI review traces biological age measurement from functional tests and blood biomarkers to epigenetic, proteomic, imaging, wearable, and AI-based clocks. It finds that these tools can improve risk prediction beyond chronological age, but standardization, interpretability, and prospective validation are needed before routine clinical use.

18 Jun 2026

Aircraft emissions could double air pollution deaths by 2040

Scenario-based modeling projects that aviation-related air pollution could drive a major rise in premature deaths by 2040, mainly through PM2.5 and ozone exposure. The study estimates that aircraft emissions caused 33,900 PM2.5-related deaths and 24,600 ozone-related deaths in 2019, with baseline 2040 deaths projected to more than double.

18 Jun 2026

Gut microbes may help explain why obesity and type 2 diabetes become harder to reverse

This review describes how gut microbial messengers, including SCFAs, microbiota-modified bile acids, neuroactive metabolites, and extracellular vesicles, may shape obesity and type 2 diabetes through the microbiota-gut-brain axis.

17 Jun 2026

AI diagnostic errors raise hospital blame unless doctors stay deeply involved

A two-study vignette experiment found that people attributed more responsibility to hospitals and were more likely to consider filing a complaint or taking legal action when missed diagnoses involved AI rather than a physician alone. Interactive physician involvement reduced negative reactions, while autonomous or sequential AI-human collaboration did not meaningfully improve responses compared with AI-only diagnosis.

17 Jun 2026

Microplastics worsen liver damage under high-fat dietary conditions

Microplastics – minuscule pieces of plastic broken down from larger plastic waste – are a growing concern for human health, especially for the liver.

17 Jun 2026

Men's fertility-friendly underwear may be briefs without benefits

A narrative review found that tight-fitting underwear may modestly raise scrotal temperature and is inconsistently linked to lower sperm production measures. However, current evidence does not show that switching to looser underwear improves real-world fertility outcomes.

17 Jun 2026

Researchers uncover genetic cause of spontaneous spinal CSF leaks

Researchers at Cedars-Sinai Health Sciences University and Johns Hopkins University have identified genetic mutations that may explain why some people develop a spontaneous cerebrospinal fluid (CSF) leak in the spine.

17 Jun 2026

First human trial targets aging immune cells for healthier immunity

A first-in-human clinical trial of an immune rejuvenation therapy designed to restore the function of worn-out T cells is expected to begin later this year, building on research led by UCL scientists into the mechanisms of immune aging.

17 Jun 2026

WashU study identifies shared target for a new diarrhea vaccine

The bacteria enterotoxigenic E. coli and Shigella together cause hundreds of millions of infections each year and are among the leading causes of diarrheal death, especially in children.

17 Jun 2026

Key Alzheimer's protein actively protects neurons from nuclear damage

Researchers at Niigata University's Brain Research Institute have uncovered a new function of amyloid precursor protein (APP), a molecule long studied as the precursor to amyloid-β (Aβ) in Alzheimer's disease (AD).

17 Jun 2026

Developing brain cells routinely repair severe DNA damage during migration

Newborn nerve cells must squeeze through crowded, narrow spaces-through dense tissue, past other cells, between fibers-to reach the areas where they form neural circuits in the brain cortex.

17 Jun 2026

Houston Methodist study reveals how strep bacterium causes infection

A fast-rising strep bacterium has become increasingly notorious for causing serious infections in humans, including complications that can lead to muscle damage and patient death. New Houston Methodist research appearing in The American Journal of Pathology, published by Elsevier, sheds light on how Streptococcus dysgalactiae subspecies equisimilis (SDSE) causes disease and may provide important insights to aid in vaccine development.

17 Jun 2026

Scientists identify unique receptor that accelerates early neuron growth

Cells have surface receptors that couple to proteins and other molecules to initiate or inhibit certain behaviors.

17 Jun 2026

Engineered cartilage grafts improve surgery for narrowed child airways

A study led by researchers at Children's Hospital of Philadelphia (CHOP) demonstrated a new method of using decellularized cartilage with patient-specific cells to help enlarge the pediatric airways narrowed as a result of severe subglottic stenosis.

17 Jun 2026

Experts outline a multidisciplinary approach to managing clinical obesity

The rapid rise of GLP-1 medications such as semaglutide and tirzepatide has transformed obesity treatment.

17 Jun 2026

Infant limb movement during sleep follows a rhythmic cycle

Infants' activity whilst sleeping is rhythmic, according to a new study from the University of Surrey. Findings provide crucial insight into sleep cycles of infants in the first year of life.

17 Jun 2026

New protein discovery could lead to safer antithrombotic therapies

Antiplatelet drugs are one of the main tools used to prevent thrombus formation in people who have had a heart attack or stroke or who have cardiovascular diseases with a high thrombotic risk.

17 Jun 2026

Targeting immune cells could improve colorectal cancer treatments

Researchers at the Medical University of Vienna have described a mechanism in metastatic colorectal cancer that has received little attention to date: a key target of existing therapies, the so-called epidermal growth factor receptor (EGFR), is likely to affect more than just the cancer cells themselves.

17 Jun 2026

Study shows how career interests translate into major life choices across decades

Career interest tests can be very helpful for teenagers and young adults deciding which careers to pursue. New research from Michigan State University challenges the assumption that vocational interests are only relevant for early career decision-making; rather, they remain relevant into adulthood.

17 Jun 2026