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Urine-based microRNA clock predicts biological aging without a blood test

Researchers developed and validated a non-invasive urinary microRNA aging clock using extracellular vesicle miRNAs from more than 6,000 adults. The model predicts age with about 4 to 5 years error and links accelerated aging signals to type 2 diabetes.

16 Dec 2025

Salutogenic microbes offer new pathways to better health

Viruses and bacteria get a bad rap around the world but now Flinders University experts are identifying the positive 'upside' of powerful benefits that microbes have on human health.

16 Dec 2025

Specific gut bacterium reduces weight gain and improves metabolic health

The gut microbiome is intimately linked to human health and weight. Differences in the gut microbiome-the bacteria and fungi in the gut-are associated with obesity and weight gain, raising the possibility that changing the microbiome could improve health.

16 Dec 2025

Global nuclear medicine organizations unite to standardize quantitative PET imaging

Three world-leading nuclear medicine organizations--the SNMMI Clinical Trials Network (SNMMI-CTN), the Australasian Radiopharmaceutical Trials Network (ARTnet), and the European Association of Nuclear Medicine Forschungs GmbH (EARL)--have jointly endorsed a unified PET/CT and PET/MR scanner accreditation framework to standardize and harmonize quantitative PET imaging worldwide.

16 Dec 2025

Opposing protein forces fine tune mRNA stability in human cells

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders - including cancers, neurodegenerative diseases and immune disorders - originate, as well as how to potentially treat them, according to researchers at Penn State.

16 Dec 2025

Blocking a key cell pathway reduces muscle wasting in pancreatic cancer

Researchers at the University of Houston are pushing the boundaries of biomedical innovation with a discovery that could transform treatment for one of cancer's most devastating complications.

16 Dec 2025

Researchers identify partner protein that supports appetite regulating-protein

A protein essential to the human body for managing energy and regulating appetite relies on a partner protein, according to new research, and the findings could help researchers better understand genetic obesity.

16 Dec 2025

New diagnostic chip enables rapid monitoring of brain cancer treatment

New diagnostic chip pulls packets released from tumor cells out of blood, showing whether cancer cells died during chemotherapy infusion.

16 Dec 2025

New rapid blood test enables early and accurate diagnosis of ALS

ALS is a debilitating paralytic disease characterized by the death of upper and lower motor neurons. Fortunately, ALS is relatively rare, with an incidence rate of 1.6 per 100,000 adults, resulting in about 30,000 cases in the United States at any one time.

16 Dec 2025

Targeted mRNA vaccines train the immune system to destroy cancer cells

No matter where cancer cells grow in the human body, they are a threat to our health and our lives. But instead of treating them with chemotherapy or radiation - which have undesirable side effects - what if we could train our own immune systems to kill the rogue cells?

16 Dec 2025

Lentilactobacillus kefiri can prevent and even reverse aging-related immune alterations

The process of aging is associated with a decline in immune functions and persistent low-level inflammation.

16 Dec 2025

MEA-driven graph modeling identifies early connectivity changes linked to autism

Multi-electrode arrays (MEAs) provide a noninvasive interface with sub-millisecond temporal resolution and long-term, multi-site recordings, enabling mechanistic investigations of in vitro human brain development and disease-related dysfunction; nevertheless, conventional MEA pipelines largely rely on firing/burst statistics or channel-/waveform-level features, which can be insufficient to systematically characterize and interpret network-level organization and its subtle pathological deviations.

16 Dec 2025

Pathology AI models show demographic bias in cancer diagnosis

Pathology has long been the cornerstone of cancer diagnosis and treatment. A pathologist carefully examines an ultrathin slice of human tissue under a microscope for clues that indicate the presence, type, and stage of cancer.

16 Dec 2025

Unlocking antibody assembly secrets with AI

During this unique study, scientists sought to understand if artificial intelligence could be used to predict how the interior of antibodies are assembled in the body.

16 Dec 2025

Revolutionary quantum sensors could enable earlier cancer diagnosis and treatment

A revolutionary quantum sensing project that could transform cancer treatment by tracking how immune cells interact with tumors has been awarded a prestigious £2 million Future Leaders Fellowship.

16 Dec 2025

Frog-derived bacteria offer dual-action anticancer effects and high safety

A research team of Prof. Eijiro Miyako at the Japan Advanced Institute of Science and Technology (JAIST) has discovered that the bacterium Ewingella americana, isolated from the intestines of Japanese tree frogs (Dryophytes japonicus), possesses remarkably potent anticancer activity. This groundbreaking research has been published in the international journal Gut Microbes.

16 Dec 2025

Bifunctional biomaterials for postoperative management of osteosarcoma

Osteosarcoma is the most prevalent primary malignant bone tumor in children and adolescents. The current standard treatment involves a combination of chemotherapy and radical surgical resection.

16 Dec 2025

Neuron structure variations impact sensory information processing in mice

Closely related subtypes of dopamine-releasing neurons may play entirely separate roles in processing sensory information, depending on their physical structure.

16 Dec 2025

Novel cryo-EM findings could revolutionize T cell immunotherapy design

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack dangerous cells. Yet a full understanding of how they actually work has eluded researchers.

16 Dec 2025

Relationship quality impacts heart health, study shows

With heart disease as the leading cause of death worldwide, there is growing recognition that recovery is not only physical but also emotional and social. A new study shows that strong and supportive relationships can indeed improve heart health for individuals with cardiovascular disease.

16 Dec 2025