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Antisense oligonucleotides reverse rare neurodevelopmental disorder in preclinical models

Scientists at St. Jude Children's Research Hospital have found they can reverse the effects of HNRNPH2-related neurodevelopmental disorder using antisense oligonucleotides (ASOs) in preclinical models. ASOs are short synthetic nucleic acid strands that target specific messenger RNA.

22 Apr 2026

Experimental drug kills aggressive breast cancer by toxic fat buildup

An experimental drug targeting triple-negative breast cancer overwhelms cancer cells with toxic fats, according to new tests on human-derived tumors in mice.

22 Apr 2026

New fiber probe enables real-time monitoring of key biomarkers

A new fiber probe developed by researchers at The University of Texas at Austin delivers two major innovations in health monitoring to help both patients around the world and the clinicians who care for them.

22 Apr 2026

Research suggests randomness behind rare cases of twin ovulation

Each month during a woman's menstrual cycle, an ovary prepares 10-20 antral follicles, fluid filled sacs that hold immature eggs, for maturation.

22 Apr 2026

Heavy drinking linked to next day cognitive problems in students

When college students drink very heavily or to the point of blacking out, they're more likely to report poorer cognitive functioning the next day, like forgetting someone's name or having trouble making decisions, according to new research from the University of Oregon.

22 Apr 2026

New antibody mechanism selectively suppresses harmful immune responses

The immune system is our frontline protection against infection, continually searching for and destroying unknown pathogens.

22 Apr 2026

Blood protein levels shift significantly from childhood through early adulthood

Blood protein levels change markedly already during childhood and adolescence, and differences between girls and boys become increasingly pronounced with age.

22 Apr 2026

Global experts highlight new strategies to target human aging

A new meeting report was published in Volume 18 of Aging-US on April 6, 2026, titled "Toward actionable interventions in human aging (12th ARDD meeting, 2025)."

22 Apr 2026

Study links common herbicide to rising early-onset colorectal cancer risk

Researchers used DNA methylation-based “epigenetic fingerprints” as proxies for lifelong exposome-related patterns and found that early-onset colorectal cancer was associated with lower Mediterranean diet adherence, lower education, smoking-related signatures, and higher picloram-related exposure signals. They then supported the picloram association in nine independent cohorts and with 21 years of US county-level pesticide-use data, while noting that the findings show association rather than proof of causation.

22 Apr 2026

Low-plastic diets cut plastic-linked chemicals in urine within 7 days, study finds

A Nature Medicine study found that healthy Australian adults were widely exposed to plastic-associated chemicals, with processed, packaged, and canned foods emerging as important modifiable contributors to urinary phthalate and bisphenol levels. In a 7-day pilot randomized trial, low-plastic food interventions reduced several urinary plastic-associated chemicals without lowering daily energy intake.

22 Apr 2026

Acupuncture regulates immune function through specific neural circuit activation

Traditional explanations of acupuncture often emphasize direct acupoint-organ relationships, focusing on local stimulation or endpoint physiological changes.

22 Apr 2026

Patient outcomes vary by drug class despite achieving clinical remission

A study published in Rheumatology & Autoimmunity challenges the assumption that achieving clinical remission in rheumatoid arthritis is sufficient, showing that patient-reported outcomes vary significantly by drug class even when disease activity is comparable.

22 Apr 2026

Survey of families suggests high risks for electroconvulsive therapy

Electroconvulsive therapy (ECT), which involves passing electricity through the brain under general anesthesia to cause a seizure, usually between six and twelve times, is used to varying degrees around the world for patients with depression and other mental conditions.

22 Apr 2026

Breast milk sugars promote beneficial bacterial balance in infant guts

Sugars contained exclusively in breast milk are helping to feed an important balance of bacteria in babies' developing gut microbiomes, a new study has found.

22 Apr 2026

Large brain mapping dataset expands with new set of cognitive tasks

The Individual Brain Charting (IBC) project has released its fifth and largest update of high-resolution fMRI data, adding a new set of cognitive tasks to one of the most detailed brain-mapping datasets available today.

22 Apr 2026

Cleveland Clinic expert proposes global heart allocation to address health inequities

Today at the 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Eileen Hsich, MD, of the Cleveland Clinic, outlined a bold vision for the future of heart transplantation that moves beyond national borders to address global inequities in organ allocation.

22 Apr 2026

Study shows older lung recipients can achieve outcomes comparable to youth

Today at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual meeting and Scientific Sessions, transplant specialists Brian Keller, MD, PhD, and Thomas Egan, MD debated an ethically fraught question: How old is too old for a lung transplant?

22 Apr 2026

Tumor immune cell patterns predict melanoma immunotherapy response

A new UCLA Health Jonsson Comprehensive Cancer Center study suggests that the way immune cells are organized inside melanoma tumors may help researchers better understand which patients will benefit from combination immunotherapy after standard anti-PD-1 treatment stops working - and which may not.

22 Apr 2026

New molecule weakens glioblastoma and enhances immune response

A team of researchers from Brown University Health and Brown University has uncovered an important clue in the fight against glioblastoma, the most common and aggressive form of brain cancer in adults.

21 Apr 2026

New guideline recommends combined therapies for chronic insomnia treatment

A new clinical practice guideline from the American Academy of Sleep Medicine provides evidence‑based recommendations on the combined use of behavioral‑psychological and pharmacological therapies to treat chronic insomnia disorder in adults.

21 Apr 2026