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Indiana University physician joins FDA panel on male hormone therapy

Helen Bernie, DO, MPH, assistant professor of urology at Indiana University School of Medicine, will participate in an expert panel on testosterone replacement therapy and men's health to be held Wednesday, Dec. 10, by the U.S. Food and Drug Administration. Bernie's role on the panel is that of a clinical expert on men's reproductive health, which is the focus of both her practice and academic research.

12 Dec 2025

Immune checkpoint inhibitors can trigger rare immune thrombocytopenia in cancer patients

Researchers led by investigators at Mass General Brigham have published valuable information about a rare but serious complication of anti-cancer immunotherapy, providing the first large-scale description of its risk factors and clinical course, and underscoring the importance of early diagnosis and treatment.

12 Dec 2025

Exploring melatonin therapeutic potential in systemic lupus erythematosus

A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus (SLE), a complex autoimmune disease affecting multiple organs.

12 Dec 2025

Glycation stress drives aortic stiffening through oxidative stress and senescence

A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled "Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence."

12 Dec 2025

Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

Heart attacks that occur at night are less severe than those that strike during the day. A new study from the Centro Nacional de Investigaciones Cardiovasculares (CNIC) explains why. Published in the Journal of Experimental Medicine, the study led by Dr. Andrés Hidalgo's group at the CNIC shows that neutrophils-a type of white blood cell-have an internal clock that regulates their aggressiveness throughout the day and determines the extent of damage they cause to the heart after a heart attack.

12 Dec 2025

Tianjin grading system improves prognosis prediction in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is notoriously difficult to treat due to its aggressive nature and limited prognostic tools.

12 Dec 2025

Autoimmune attack on CASPR2 drives nerve hyperexcitability and involuntary muscle activity

A scientific review on autoimmune neurological diseases reveals what occurs in our body when the immune system, by mistake, produces antibodies that target a protein essential for the normal functioning of nerves.

12 Dec 2025

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, and TaiGen Biotechnology, a listed discovery-based and market-focused pharmaceutical company, as well as TaiGen Biopharmaceuticals, its wholly-owned Beijing subsidiary (both referred to as "TaiGen"), today announced an exclusive pipeline out-licensing collaboration.

12 Dec 2025

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

The interaction between genetics and tissue environment shapes how individual teeth form in different regions of the jaw.

12 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation.

12 Dec 2025

Most clinical trials fail to reflect America’s racial and ethnic diversity

A new study finds just 6% of clinical trials used to approve new drugs in the U.S. reflect the country's racial and ethnic makeup, with an increasing trend of trials underrepresenting Black and Hispanic individuals.

12 Dec 2025

EULAR proposes new guidance to assess disease activity in adult-onset Still’s disease

EULAR - The European Alliance of Associations for Rheumatology - has identified an unmet clinical need around the assessment of disease activity in people with adult-onset Still's disease.

12 Dec 2025

Massive genetics study shows what truly separates and unites 14 psychiatric disorders

This large-scale genomic analysis of 14 psychiatric disorders shows that most heritable risk is shared across five broad genetic factors, with only limited disorder-specific variation. The study maps where risks converge or diverge biologically, revealing distinct cell type signatures and developmental pathways that may guide future diagnostic and therapeutic frameworks.

12 Dec 2025

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Researchers outline why organs from older donors are often discarded and identify the biological and immunological pathways that make them vulnerable to injury. They also highlight emerging rejuvenation technologies including machine perfusion, senotherapeutics, and regenerative strategies that could safely expand the donor pool.

11 Dec 2025

New findings show why the human intestine uniquely presents gluten to T cells

Human intestinal M cells function as dendritic cell-like antigen-presenting cells, displaying constitutive MHC-II activity and specialized machinery for processing gluten. Their ability to deamidate and present gliadin peptides positions them as key initiators of immune responses relevant to coeliac disease.

11 Dec 2025

What happens to your body when you eat takeaway food too often?

This study of 8,556 US adults shows that frequent takeaway food consumption is associated with a higher energy-adjusted Dietary Inflammatory Index and adverse cardiometabolic markers. The findings suggest that reducing takeaway intake and lowering dietary inflammatory potential may improve long-term cardiometabolic health.

11 Dec 2025

New blood biomarker predicts brain damage after cardiac arrest

A blood biomarker yet to be used in cardiac arrest care can give a clearer picture of the extent of brain damage after a cardiac arrest.

11 Dec 2025

Study reveals stepwise formation of cerebellar projections in the developing brain

A team of researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has reconstructed for the first time how the cerebellum establishes its connections with the rest of the brain during the earliest stages of life.

11 Dec 2025

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.

11 Dec 2025

Medical Science News

Indiana University physician joins FDA panel on male hormone therapy

Immune checkpoint inhibitors can trigger rare immune thrombocytopenia in cancer patients

Exploring melatonin therapeutic potential in systemic lupus erythematosus

Glycation stress drives aortic stiffening through oxidative stress and senescence

Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

Tianjin grading system improves prognosis prediction in pancreatic cancer

Autoimmune attack on CASPR2 drives nerve hyperexcitability and involuntary muscle activity

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Most clinical trials fail to reflect America’s racial and ethnic diversity

EULAR proposes new guidance to assess disease activity in adult-onset Still’s disease

Massive genetics study shows what truly separates and unites 14 psychiatric disorders

Scientists outline how organ rejuvenation strategies could solve the donor shortage

New findings show why the human intestine uniquely presents gluten to T cells

What happens to your body when you eat takeaway food too often?

New blood biomarker predicts brain damage after cardiac arrest

Study reveals stepwise formation of cerebellar projections in the developing brain

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

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