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Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression.

31 Oct 2025

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction.

31 Oct 2025

GeneSight test-guided treatment leads to faster remission and response in patients with depression

Myriad Genetics, Inc., a leader in molecular diagnostic testing and precision medicine, today announced a post-hoc analysis of the Precision Medicine in Mental Health Care (PRIME) study showed that treatment informed by the GeneSight® test led to faster initial remission and response in patients with Major Depressive Disorder (MDD).

31 Oct 2025

Pioneering technology enables scalable production of human kidney organoids

A research team led by the Institute for Bioengineering of Catalonia (IBEC) and collaborating with the Biomedical Research Institute of A Coruña (INIBIC), as well as other international research groups, has developed pioneering technology that enables human kidney organoids to be produced in a scalable manner.

31 Oct 2025

Study reveals how melanoma evolves to resist immunotherapy

A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators reveals how melanoma, the deadliest form of skin cancer, evolves to resist immunotherapy and identifies a potential strategy to prevent or reverse that resistance.

31 Oct 2025

Scripps Research scientists receive NIH grant to unlock long-term HIV protection

Nearly 40 years after HIV was first identified, the virus continues its devastating march across the globe. Today, 38 million people live with HIV, and each year brings 1.5 million new infections and 650,000 more deaths-while nearly 10 million people still lack access to life-saving medicines.

31 Oct 2025

Innovations and challenges in global contraception and family planning

Contraception and family planning are vital aspects of sexual and reproductive health and rights. Despite major advances in modern contraception over the past 60 years, many gaps remain and the rate of unplanned pregnancies and abortions remains high.

31 Oct 2025

Lab-grown organoid offers a platform to study how liver scarring develops

As chronic liver disease becomes more widespread, researchers at Science Tokyo have developed a lab-grown organoid that replicates a regenerating liver, offering new hope for future treatments.

31 Oct 2025

Neuroscientists uncover a surprising role for "Frazzled" protein in the nervous system of fruit flies

Florida Atlantic University neuroscientists have uncovered a surprising role for a protein named "Frazzled" (known as DCC in mammals) in the nervous system of fruit flies, showing how it helps neurons connect and communicate with lightning speed.

31 Oct 2025

Genetic insights into vestibular system damage from ototoxic drugs

The vestibular system is responsible for the sense of balance in the inner ear. Prolonged use of toxic substances, such as certain antibiotics or anticancer drugs, can damage the hair cells that form part of this system, leading to alterations in balance and other motor skills.

31 Oct 2025

New method enhances precision in bionic limb movement interpretation

Despite enormous progress in the past two decades, the intentional control of bionic prostheses remains a challenge and the subject of intensive research.

31 Oct 2025

Mathematical models explain food movement and churning in the digestive tract

Synchronization abounds in nature: from the flashing lights of fireflies to the movement of fish wriggling through the ocean, biological systems are often in rhythmic movement with each other.

31 Oct 2025

How nerve cells in the gut adapt to microbial and immune challenges

Ramnik Xavier, MD, PhD, of the Department of Molecular Biology at Massachusetts General Hospital, is the senior author of a paper published in Science, "Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation."

31 Oct 2025

Novel approaches to understanding EETs and cardiovascular disease

Some products of arachidonic acid have already been well studied: the prostanoids formed by cyclooxygenases are central mediators of inflammation, fever, and pain.

31 Oct 2025

Exploring the link between underweight status and gut microbiota composition in Japanese women

Low body weight in young women has been linked to a range of health concerns, including disrupted menstrual cycles, infertility, weakened immune function, and a long-term decline in bone density.

31 Oct 2025

Researchers visualize how brain network development is altered in rare childhood disorder

Researchers at the VIB-UAntwerp Center for Molecular Neurology have visualized how brain network development is altered in a model of KCNQ2-related developmental and epileptic encephalopathy, a rare childhood brain disorder.

31 Oct 2025

Sensory effects of flavanols trigger physiological responses in the brain

Astringency is a dry, puckering, rough, or sandpapery sensation in the mouth caused by plant-derived polyphenols.

31 Oct 2025

Evidence of previously unrecognized hub in the brain's lymphatic drainage system revealed

How does the brain take out its trash? That is the job of the brain's lymphatic drainage system, and efforts to understand how it works have pushed the boundaries of brain-imaging technologies.

31 Oct 2025

Study reveals how TDP-43 causes neuronal overactivity in ALS and FTD

A new Northwestern University study using patient nervous tissue and lab-grown human neurons has uncovered how a key disease protein, TDP-43, drives overactive nerve cells in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

31 Oct 2025

Global study suggests potential for universal vaccine against Haemophilus influenzae

A vaccine that tackles the bacteria that cause up to 200 million childhood infections every year could be possible, experts say.

31 Oct 2025

Medical Science News

Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

GeneSight test-guided treatment leads to faster remission and response in patients with depression

Pioneering technology enables scalable production of human kidney organoids

Study reveals how melanoma evolves to resist immunotherapy

Scripps Research scientists receive NIH grant to unlock long-term HIV protection

Innovations and challenges in global contraception and family planning

Lab-grown organoid offers a platform to study how liver scarring develops

Neuroscientists uncover a surprising role for "Frazzled" protein in the nervous system of fruit flies

Genetic insights into vestibular system damage from ototoxic drugs

New method enhances precision in bionic limb movement interpretation

Mathematical models explain food movement and churning in the digestive tract

How nerve cells in the gut adapt to microbial and immune challenges

Novel approaches to understanding EETs and cardiovascular disease

Exploring the link between underweight status and gut microbiota composition in Japanese women

Researchers visualize how brain network development is altered in rare childhood disorder

Sensory effects of flavanols trigger physiological responses in the brain

Evidence of previously unrecognized hub in the brain's lymphatic drainage system revealed

Study reveals how TDP-43 causes neuronal overactivity in ALS and FTD

Global study suggests potential for universal vaccine against Haemophilus influenzae

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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