Interleukin 2 News and Research

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New route discovered for attacking the human immunodeficiency virus

A research group supported by the National Institutes of Health (NIH) has uncovered a new route for attacking the human immunodeficiency virus (HIV) that may offer a way to circumvent problems with drug resistance. In findings published today in the online edition of the Proceedings of the National Academy of Sciences, the researchers report that they have blocked HIV infection in the test tube by inactivating a human protein expressed in key immune cells.

28 Apr 2008

Metabolic genes tied to inflammatory predictor of heart disease and stroke risk

Two new studies provide evidence that differences in people's blood levels of C reactive protein (CRP) stem in part from natural variation in known metabolic genes. The researchers report their findings in the May American Journal of Human Genetics, a publication of Cell Press.

24 Apr 2008

Study details cost-effectiveness of rheumatoid arthritis treatments for Medicare recipients

For elderly and disabled rheumatoid arthritis (RA) sufferers, the Medicare Prescription Drug Improvement and Modernization Act (MMA) brought the promise of better disease management with "biologic" drugs.

15 Apr 2008

DASH diet also may cut risk for heart disease, stroke

Women who eat diets similar to the Dietary Approaches to Stop Hypertension (DASH) diet -which is low in animal protein, moderate in low-fat dairy products and high in plant proteins, fruits and vegetables - appear to have a lower risk of coronary heart disease and stroke, according to a report in the April 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

15 Apr 2008

Researchers study Rituximab's action on cancer stem cells

Preliminary data from one of the first clinical trials to test a stem cell-targeting drug in cancer patients shows that while the drug did not prolong survival, its suppressing effect on patients' stem cells was impressive enough to send investigators looking for a better drug to try.

13 Apr 2008

Long-term interleukin-6 levels and subsequent risk of coronary heart disease

In research published in the open access journal PLoS Medicine this week, John Danesh of the University of Cambridge and colleagues find that interleukin-6 (IL-6) levels (a type of protein produced by inflammation, attracting cells of the immune system to the site of injury) are associated with coronary heart disease.

8 Apr 2008

Tart cherries cut heart/diabetes risk factors

Tart cherries - frequently sold dried, frozen or in juice - may have more than just good taste and bright red color going for them, according to new animal research from the University of Michigan Cardiovascular Center.

7 Apr 2008

New clues to risk of Hodgkin lymphoma discovered

A long-term study of twins has led University of Southern California (USC) researchers to find potential links between Hodgkin lymphoma and levels of an immune response protein (interleukin-12).

2 Apr 2008

Tai Chi improves control of type 2 diabetes

Tai Chi exercises can improve the control of type 2 diabetes, suggests a small study, published ahead of print in the British Journal of Sports Medicine.

1 Apr 2008

EpiCept announces opinion by European Regulatory Authority on Ceplene

EpiCept Corporation has announced that the European Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMEA), has issued, as expected following the trend vote announced last month, a negative opinion regarding the marketing authorization application (MAA) for Ceplene (histamine dihydrochloride) for the remission maintenance and prevention of relapse of patients with Acute Myeloid Leukemia (AML) in first remission.

24 Mar 2008

MedImmune advances clinical development of antibody targeting interleukin-9 in patients with asthma

MedImmune has announced that its clinical program studying an investigational treatment targeting interleukin-9 (IL-9) has advanced with the start of a new trial in patients with asthma.

19 Mar 2008

New understanding of rare immune disorder called Job's syndrome

Scientists have made another major breakthrough--the second in the past year--in understanding a rare immune disorder called Job's syndrome.

18 Mar 2008

Obese ICU patients have lower mortality but longer ICU stays

Obese intensive care patients do not have a higher ICU death rate than non-obese ICU patients, but they remain in the ICU significantly longer and are intubated significantly longer than non-obese patients, a new study has found.

18 Mar 2008

Finding in mice could help prevent common complications of kidney damage

Kidney damage often sets off a slew of complications in patients, spreading organ failure like wildfire throughout their bodies.

14 Mar 2008

Poor sleep more dangerous for women

Researchers at Duke University Medical Center say they may have figured out why poor sleep does more harm to cardiovascular health in women than in men.

11 Mar 2008

Aromatherapy and pain relief?

One of the most comprehensive investigations done to date on aromatherapy failed to show any improvement in either immune status, wound healing or pain control among people exposed to two often-touted scents.

4 Mar 2008

FDA approves Arcalyst for treatment of rare inflammatory syndromes

The U.S. Food and Drug Administration has approved a drug to help ease the suffering faced by those with certain chronic inflammatory diseases.

28 Feb 2008

Protein that stimulates blood vessel growth worsens ovarian cancer

A protein that stimulates blood vessel growth worsens ovarian cancer, but its production can be stifled by a tiny bit of RNA wrapped in a fatty nanoparticle, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Journal of the National Cancer Institute.

27 Feb 2008

Vaccinex antibody licensed to GlaxoSmithKline

EUSA Pharma (Oxford, UK), a Vaccinex collaboration partner, has announced that it has licensed OP-R003, a human anti-interleukin-6 antibody discovered by Vaccinex, to GlaxoSmithKline.

18 Feb 2008

Hostility plus depression elevates risk for heart disease

Researchers led by Jesse Stewart, Ph.D., assistant professor of psychology at Indiana University-Purdue University Indianapolis, report that hostility and depression appear to act together in a complex way to elevate inflammatory proteins in the human body, possibly putting hostility plus depression on the list of risk factors for heart disease along with high blood pressure, elevated cholesterol, and smoking.

12 Feb 2008