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Insilico Medicine uses AI to discover novel SIK2 inhibitors

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has achieved a significant breakthrough in the application of multiple generative AI models and AlphaFold structures for drug discovery.

2 Aug 2023

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine

A recent study elucidated the molecular mechanisms of drug-induced regulation of growth differentiation factor 15 (GDF15).

1 Aug 2023

Two new compounds can block cancer cell’s escape route

Cancer cells are capable of escaping chemotherapy and radiotherapy by activating a signaling pathway that prevents them from dying.

27 Jul 2023

Positive experiences can reverse cognitive decline in old age

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, "MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan."

26 Jul 2023

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Study aimed to understand the specific needs of lung cancer in never smokers (LCINS) patients.

25 Jul 2023

Could alpha lipoic acid treat polycystic ovary syndrome?

Authors analyzed the efficacy of alpha lipoic acid (ALA) in treating polycystic ovary syndrome (PCOS).

24 Jul 2023

KIPA shows promise in predicting chemotherapy response in triple negative breast cancer

Researchers at Baylor College of Medicine and collaborating institutions are developing a strategy to predict the response of triple negative breast cancer (TNBC) to chemotherapy, which would be a valuable tool for physicians deciding on the treatment with better probability of success on an individual basis.

21 Jul 2023

ECOG-ACRIN launches new trial to evaluate nilotinib and paclitaxel for advanced cancers

The ECOG-ACRIN Cancer Research Group has enrolled the first patient in a new treatment trial to evaluate the effectiveness of adding nilotinib to standard paclitaxel chemotherapy.

20 Jul 2023

Study explores the effectiveness of caffeine consumption for headaches: trigger or remedy?

Caffeine has a dual role in headaches as it can induces or remediate them.

20 Jul 2023

Understanding the mechanisms behind rising antifungal drug resistance

In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens.

19 Jul 2023

Eternal youth? Chemical cocktails prove effective in cell age reversal

Researchers identified chemical drug combinations that could reverse cellular aging.

19 Jul 2023

BUB1 protein and its kinase activity may regulate EGFR activation

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, "Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization."

18 Jul 2023

Kinase News and Research

Insilico Medicine uses AI to discover novel SIK2 inhibitors

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine

Two new compounds can block cancer cell’s escape route

Positive experiences can reverse cognitive decline in old age

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Could alpha lipoic acid treat polycystic ovary syndrome?

KIPA shows promise in predicting chemotherapy response in triple negative breast cancer

ECOG-ACRIN launches new trial to evaluate nilotinib and paclitaxel for advanced cancers

Study explores the effectiveness of caffeine consumption for headaches: trigger or remedy?

Understanding the mechanisms behind rising antifungal drug resistance

Eternal youth? Chemical cocktails prove effective in cell age reversal

BUB1 protein and its kinase activity may regulate EGFR activation

PhoreMost appoints Professor Peter Parker and Dr Jason Imbriglio to Scientific Advisory Board

Cryo-EM reveals structure of key enzyme involved in protein production

New study reveals how lung tumors develop drug resistance

Overdosed gene on chromosome 21 accelerates aging in people with Down's syndrome

Difficult transmembrane protein targets for therapeutic antibodies

Novel protein modifies the cellular machinery responsible for producing cellulose in plant cells

New research sheds light on role of progesterone in breast cancer

New study shows circulating anti-insulin CD4 T cells reflect progression of anti-islet immunity

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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