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Combination treatments reduce blood pressure in patients taking ibrutinib

Combination treatments with two or more blood pressure drugs can significantly reduce blood pressure in patients taking ibrutinib, according to a new study published in Blood Advances.

5 Feb 2024

PI3K/AKT and MEK/ERK pathways targeted in new therapy for docetaxel-resistant prostate cancer

A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research Institute (IGTP) have found a new therapeutic strategy for patients with a specific subtype of metastatic prostate cancer resistant to standard chemotherapy treatment with docetaxel.

5 Feb 2024

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations has identified a next-generation BTK degrader that could help overcome treatment resistance in chronic lymphocytic leukemia (CLL) and related blood cancers.

1 Feb 2024

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures.

1 Feb 2024

European scientists target high-risk childhood cancer with liquid biopsy

Neuroblastoma mainly affects toddlers and young children - in the EU region there are 1500 new cases per year.

29 Jan 2024

Study addresses knowledge gap of clinical features and outcomes of Black patients with melanoma

Researchers identified patient- and tumor-level melanoma features in black individuals.

25 Jan 2024

Persistent presence of SARS-CoV-2 RNA found in long COVID patients

Researchers conduct blood digital transcriptomics to determine the persistence of SARS-CoV-2 RNA in patients with long COVID-19.

23 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

Evaluating the effectiveness and safety of single-port robot-assisted technique in nipple-sparing mastectomy procedures

Researchers evaluated the safety and feasibility of a single-port (SP) robotic-assisted approach for performing nipple-sparing mastectomies (NSM).

19 Jan 2024

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Researchers compared SARS-CoV-2 Omicron variant of concern replication in human cell lines and primary airway cultures and measured host responses to infection.

19 Jan 2024

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

Researchers use a mathematical model to assess the efficacy of a new combinational therapy of AZD9496 and palbociclib for breast cancer treatment.

18 Jan 2024

ALS progression linked to mitochondria-associated membrane-ER disconnection

Researchers at Nagoya University in Japan have discovered a relationship between the progression of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the disruption of mitochondria-associated membranes (MAM), the contact point between the mitochondria and the endoplasmic reticulum (ER) of the cell.

17 Jan 2024

Unlocking the anti-inflammatory secrets of bergamot byproducts

The positive effect of bergamot derivatives.

17 Jan 2024

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Excessive alcohol intake is strongly associated with alcohol-associated liver disease (ALD) which accounts for 25% and 30% of deaths from cirrhosis and hepatocellular carcinoma. Impairment of Ca2+ influx and Ca2+-mediated signaling in ALD suggests that Ca2+ channels are important in ALD pathological progression.

16 Jan 2024

Kinase News and Research

Combination treatments reduce blood pressure in patients taking ibrutinib

PI3K/AKT and MEK/ERK pathways targeted in new therapy for docetaxel-resistant prostate cancer

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

European scientists target high-risk childhood cancer with liquid biopsy

Study addresses knowledge gap of clinical features and outcomes of Black patients with melanoma

Persistent presence of SARS-CoV-2 RNA found in long COVID patients

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Evaluating the effectiveness and safety of single-port robot-assisted technique in nipple-sparing mastectomy procedures

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

ALS progression linked to mitochondria-associated membrane-ER disconnection

Unlocking the anti-inflammatory secrets of bergamot byproducts

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

Revolutionary AI tool forecasts kidney injury signs with high accuracy in intensive care

Pazopanib activity confirmed in EWSR1-NFATC2 bone sarcoma

Breakthrough in diabetes management: Cold water exercise and cinnamon shows promising results

Key protein EPAC1 found to regulate brown fat growth, offering obesity treatment potential

Glioblastoma tumor cells mimic neurons to evade treatment

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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