Kinase Inhibitor News and Research

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A protein kinase inhibitor is a type of enzyme inhibitor that specifically blocks the action of one or more protein kinases.

New compound, ZK-CDK combines the inhibition of tumour cell growth as well as inhibition of tumour angiogenesis in one single molecule

Treatment with a new dual cell cycle and angiogenesis pathway inhibitor blocks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models

7 Jul 2004

Exelixis files new drug application for a proprietary novel anticancer compound

Exelixis, Inc. has submitted an investigational new drug application (IND) to the U.S. Food and Drug Administration (FDA) for XL999, a proprietary novel anticancer compound.

29 Jun 2004

Cancer drug gefitinib (Iressa) may be able to restore tamoxifen's anticancer activity

A new study has found a possible mechanism for tamoxifen resistance in breast cancer and provides evidence that another cancer drug--gefitinib (Iressa)--may be able to restore tamoxifen's anticancer activity.

15 Jun 2004

Oxygen delivered through the nose may improve poor vision caused by diabetic macular edema

Oxygen delivered through the nose may improve poor vision caused by diabetic macular edema, fluid buildup in the part of the eye responsible for central vision, according to a pilot study by scientists at Johns Hopkins and the National Eye Institute.

18 May 2004

Developing smart drugs

Dana-Farber Cancer Institute Researchers, sensing an opening in the cancer battle, are mounting a quick thrust to flush out suspected molecular cancer triggers in tumor cells.

30 Apr 2004

Breast feeding increases choline which means more brain cells

Five years ago, University of North Carolina at Chapel Hill researchers first reported finding that the nutrient choline played a critical role in memory and brain function by positively affecting the brain’s physical development. Differences in development influenced action, the scientists and their colleagues found. In animal experiments conducted at Duke University, both young and old rats performed significantly better on memory tasks if they received enough choline before birth compared with same-age rats whose mothers were fed choline-deficient diets. The latter showed deficits in the hippocampus and septums of their brains.

22 Mar 2004

New treatment for heart attacks

A team led by scientists at The Scripps Research Institute has developed a potential new treatment for heart attacks. The therapy inhibits fluid leakage from cardiac blood vessels following a heart attack and thereby significantly prevents long-term heart damage and improves survival.

22 Mar 2004