Knee Arthroplasty News and Research

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Knee arthroplasty or knee replacement surgery has developed to its present advanced stage over the last few decades. This is mainly due to technical advances and better understanding of knee pathophysiology and functions.

Pacira Pharmaceuticals initiates Phase 3 clinical trial of EXPAREL in femoral nerve block

Pacira Pharmaceuticals, Inc. (NASDAQ:PCRX) today announced that the Phase 3 clinical trial assessing the safety and efficacy of EXPAREL® (bupivacaine liposome injectable suspension) in femoral nerve block for total knee arthroplasty met its primary efficacy endpoint.

27 Feb 2014

Comprehensive approach to the evaluation of groin pain

She wasn't born this way, but even Lady Gaga experienced groin pain-typically a symptom of hip disease such as arthritis of the hip-or, in her case, a hip labral tear. Groin pain is a common health complaint. According to a literature review appearing in the September 2013 issue of the Journal of the American Academy of Orthopaedic Surgeons, one in four people develop hip arthritis-damage to the surfaces in the hip joint-before the age of 85 that contributes to groin pain.

18 Sep 2013

Choosing Wisely List released by The American Academy of Orthopaedic Surgeons

The American Academy of Orthopaedic Surgeons (AAOS) today released a list of specific tests or procedures that are commonly ordered but not always necessary in orthopaedics as part of the Choosing Wisely- campaign, an initiative of the ABIM Foundation. The list identifies five targeted, evidence-based recommendations that can support conversations between patients and physicians about what care is really necessary.

12 Sep 2013

Study looks at cost benefits of knee replacement surgery relative to societal, economic savings

The full impact of knee replacement surgery on both patients' lives and on society includes significant overall cost savings, according to a new study published in the Journal of Bone and Joint Surgery.

22 Aug 2013

Adynxx receives FDA Fast Track designation for AYX1 Injection to treat chronic pain

Adynxx, a clinical-stage pharmaceutical company developing a first-in-class platform of therapeutics to address pain at its molecular roots, announced today that the U.S. Food and Drug Administration has granted Fast Track designation to AYX1 Injection for the prevention of chronic pain.

17 Jul 2013

$Epidural steroid injection is associated with increased spinal fracture$

Epidural steroid injection is associated with increased spinal fracture

Most aging adults will experience back pain or a spinal disorder at some time in their life. In fact, about 25.8 million visits were made to physicians' offices due to primary back problems. Treatment focuses on pain relief and is available in both non-surgical (medication or physical therapy) and surgical forms.

7 Jun 2013

Pacira Pharmaceuticals reports results of EXPAREL Phase 2/3 clinical trial for TKA

Pacira Pharmaceuticals, Inc. today announced findings from the completed first part of its Phase 2/3 clinical trial assessing the use and administration of EXPAREL (bupivacaine liposome injectable suspension) as a single-dose injection femoral nerve block for total knee arthroplasty surgery.

29 May 2013

Lower-income individuals are more likely to report dissatisfaction with knee replacement surgery

Knee replacement surgery is a very common procedure. However, it does not always resolve function or pain in all the recipients of new knees.

22 May 2013

GE Healthcare introduces novel MR imaging technology

At an event held today at Hospital for Special Surgery, GE Healthcare introduced MAVRIC SL, a novel magnetic resonance imaging technique designed to address the growing clinical need to more accurately image soft tissue and bone in patients with MR Conditional-labeled implants, such as joint replacements and other instrumentation.

16 May 2013

SAGE announces launch of new international open access journal of sports medicine

SAGE today announces the launch of a new international open access journal, the Orthopaedic Journal of Sports Medicine. This journal was developed by the American Orthopaedic Society for Sports Medicine in collaboration with professional sports medicine organizations from around the world as a global, peer-reviewed open access journal that will publish content for both researchers and practitioners studying orthopeadic sports medicine, arthroscopy, and knee arthroplasty.

5 May 2013

BioMed Central launches new journal BMC Sports Science, Medicine and Rehabilitation

Open access publisher BioMed Central is proud to announce the launch of BMC Sports Science, Medicine and Rehabilitation, another addition to the BMC-series portfolio.

30 Mar 2013

Obesity may not diminish outcomes or increase risk of complications in total knee replacement patients

Obesity alone may not diminish outcomes or increase the risk of complications in total knee replacement (TKR) patients, according to two research studies presented today at the 2013 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). However, TKR replacement patients may face significantly longer hospital stays and related costs.

21 Mar 2013

Study: Total knee replacements in younger patients with juvenile arthritis last for 10 years

When you think of knee replacement surgery, you generally envision an older adult with painful arthritis. But the procedure is also used for younger patients with juvenile idiopathic arthritis whose joints have been severely damaged by the disease. Because the surgery in younger patients is relatively rare, little data exist on the longevity of knee replacements in JIA patients.

19 Mar 2013

Adynxx initiates AYX1 Phase 2 study to prevent post-surgical pain

Adynxx, a clinical-stage pharmaceutical company developing a first-in-class platform of therapeutics to address pain at its molecular roots, announced today that the first patient was dosed in a Phase 2 study of its lead investigational drug candidate for the prevention of post-surgical pain, AYX1.

26 Feb 2013

Knee replacement pain predicted by comorbidity

Research may help physicians give patients undergoing total knee arthroplasty a realistic expectation of surgery outcome based on their overall physical and mental health, US researchers believe.

21 Jan 2013

Anesthesia choice may benefit knee arthroplasty patients

Spinal anesthesia could reduce the risk for postoperative complications in select patients undergoing total knee arthroplasty, US researchers say.

28 Dec 2012

Comorbidity could alter joint arthroplasty prognosis

The long-term outcome of hip and knee arthroplasty may be significantly influenced by comorbidity, suggest results from a large register-based study of over 96,000 osteoarthritis patients.

22 Dec 2012

Cempra commences CEM-102 Phase 2 trial in prosthetic joint infections

Cempra, Inc., a clinical-stage pharmaceutical company focused on developing antibiotics to meet critical medical needs in the treatment of bacterial infectious diseases, today announced the initiation of its Phase 2 clinical trial of CEM-102 in patients with prosthetic joint infections (PJIs).

15 Dec 2012

No differences between computer-navigated and traditional TKA related to knee function, pain

For many years, the use of computer-assisted navigation has been touted as improving the positioning, sizing and alignment of replacement knee joints, resulting in greater durability of joints and overall improvement in patient movement. However, new research published in the Journal of Bone and Joint Surgery (JBJS) found no difference in knee function, alignment or durability/survivorship between joints positioned and completed with the help of computer navigation, and those replaced with conventional total knee arthroplasty (TKA) procedures.

21 Nov 2012

Hydrocortisone protects bilateral knee replacement patients

Repeat doses of corticosteroids may protect patients undergoing bilateral total knee arthroplasty from postoperative side effects such as fever, pain, and acute respiratory distress, research suggests.

16 Nov 2012